Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 12 of 12 for “"acyl transferase"”.
-
Characterisation of the cell-surface localised palmitoyl acyl transferase, DHHC5
… and disease pathways. DHHC palmitoyl acyl transferase (DHHC-PAT) enzymes are responsible for catalysing the addition of acyl groups onto cysteine residues and there are 23 human DHHC-PAT isoforms. All isoforms share a conserved DHHC catalytic motif and they display heterogeneity in …
-
Apolipoprotein E Activation and Phosphatidylcholine Substrate Requirements of Lecithin Cholesterol Acyl Transferase
… activation of lecithin cholesterol acyl transferase (LCAT) by human apolipoprotein E (apo E) was investigated by incorporating apo E into discoidal complexes of egg phosphatidylcholine (egg-PC) and cholesterol by the cholate dialysis method. These complexes were systematically …
-
Investigating mechanisms of triacylglycerol synthesis induced by nitrogen depletion in the diatom Phaeodactylum tricornutum and characterising its diacylglycerol acyltransferases and phospholipid: diacylglycerol acyl transferase
… tricornutum (P. tricornutum) to accumulate triacylglycerol (TAG) and synthesise the omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) has led to interest in their development for biofuels and human nutrition. Nitrogen depletion is a well-studied experimental system for …
-
HEPATIC LIPID METABOLISM: THE ROLES OF ACAT2 AND ABCG5/G8 IN THE DEVELOPMENT AND PREVENTION OF DISEASE
… the complications associated with heart disease. Acyl-CoA:Cholesterol Acyl Transferase isoform 2 (ACAT2) is an enzyme that has been implicated in the development and progression of atherosclerosis and is a target for pharmacological intervention. This dissertation describes a role for ACAT2 and …
-
The Role of the X-chromosomal Porcupine Homolog Gene in Mouse Development
… Porcn gene encodes a membrane-bound O-acyl transferase that is required for the acylation of all 19 WNT ligands encoded in the mammalian genome. Non-acylated WNTs fail to be secreted from the producing cell and thus do not activate downstream signaling targets. In my thesis research, I …
-
Polymorphic Variation of the DGAT1 Gene in Cal Poly Holstein and Jersey Breeds and the Correlation of Milk Fat Content, and Genetic Values
… alanine amino acid change) in exon VII of the diacylglycerol acyl transferase 1 (DGAT1) gene. DGAT1 is a key acyltranferase in triglyceride biosynthesis. DGAT1 encodes an enzyme which catalyzes the final step of mammalian triglyceride synthesis from carbohydrates. The K232A substitution in the …
-
Proteomics of Oxidative Stress Using Inducible CYP2E1 Expressing HepG2 Cells and 3T3-L1 Adipocytes as Model Systems
… as well as beta-oxidation enzymes; cartinine acyl transferase and long-chain enoyl-CoA hydratase up-regulated from 7 through 18 days post differentiation onset. These data indicate TCA up-regulation for enhanced metabolic and citrate output necessary for lipid synthesis in adipocytes. …
-
DHHC PROTEIN ACYLTRANSFERASES CATALYZES THE LYSINE PALMITOYLATION OF MEMBERS OF THE RAS SUPERFAMILY OF SMALL GTPASES
Protein fatty acylation is the attachment of a long-chain fatty acyl group, generally 14–16 carbons in length to the side chain of an amino acid. Cysteine palmitoylation or S-palmitoylation is best understood and widespread post-translational modification in this class, followed closely by …
-
Role of VimA in Cell Surface Biogenesis in Porphyromonas gingivalis
… analysis of VimA predicted a likely role as an acyl transferase, with structural similarities to the FemABX family of proteins – these proteins are involved in peptidoglycans synthesis. The expression profile of lipid modified 3H labeled outer membrane proteins from FLL92 when compared with W83 …
-
DEVELOPMENT OF SUSTAINABLE AND EFFICIENT TAILOR-MADE PROCESSES FOR PHARMA AND FOOD APPLICATIONS
… by case. For example, in the transfer reaction, acyl transferase from Mycobacterium smegmatis was immobilised on glyoxyl agarose by our research group while lipase-mediated reactions were performed using the commercial preparation Novozyme® 435. Redox reactions were mainly catalysed by commercial …
-
Biochemical and Rheological Characterization of Peanut Proteins Crosslinked with Microbial Transglutaminase
… protein crosslinking reactions through an acyl transferase mechanism involving protein-bound glutaminyl residues and primary amines including the -amino group of lysine residues in soy, myosin, gluten, oat globulin, casein and whey. Herein, we report exogenous TGase catalysis of several …
-
Identification of acyl transferases responsible for the diverse hydroxycinnamoyl chemical space in bidens pilosa
… of chlorogenic acids (i.e., mono-, di-, tri- acyls). The biosynthetic pathway to produce the diverse array of chlorogenic acids in B. pilosa is not yet elucidated. It is known from other plants like Helianthus annuus that the production of chlorogenic acids is coded by hydroxycinnamoyl-CoA: …