"acute protein degradation" · 2 results · Global ETD Search

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Showing 1 to 2 of 2 for “"acute protein degradation"”.

Investigating the mitotic roles of Topoisomerase 2 Alpha and Topoisomerase 2 Beta-Binding Protein 1 in the maintenance of chromosome structure and genome stability

Benoit, JudithUniversity of Cambridge2024

… are essential, evolutionarily conserved proteins, important throughout the cell cycle. They act by generating a transient double-stranded DNA break in one molecule and manoeuvring a second DNA segment through the resultant gap. This ability to catenate and decatenate DNA means that type …

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Characterisation of HIF2A targets identifies MYC as a key determinant of HIF2A dependency in ccRCC

Dyas, Anna ElizabethUniversity of Cambridge2023

… *in vivo*. I demonstrated that HIF2A can be acutely degraded in a xenograft model of ccRCC using AID2 technology, and that combining this with RNA-seq uncouples direct targets from downstream signalling cascades. This unbiased method enabled the shortlisting of clinically relevant candidate …

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