Global ETD Search
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Showing 1 to 12 of 12 for “"acute promyelocytic leukemia"”.
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… t(15;17) translocation is found in nearly 98% of acute promyelocytic leukemia: APL, FAB subtype M3) cases and results in the fusion of the promyelocytic leukemia: PML) gene with the retinoic acid receptor alpha: RARA) gene. The fusion product, PML-RARA, encodes a functionally altered transcription …
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ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
Acute promyelocytic leukemia (APL) is characterized by the appearance of blasts, insensitive to physiological retinoic acid (RA)-dependent differentiation and in the majority of the cases, expressing PML-RAR fusion protein. PML-RAR works as a dominant negative counterpart of retinoic acid receptor …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
Acute Promyelocytic Leukemia (APL) is a distinct subtype of Acute Myeloid Leukemia (AML) driven by the oncogenic fusion protein PML-RAR, which acts as an aberrant transcription factor and blocks myeloid maturation at the promyelocyte stage. In vivo, the expression of PML-RAR is necessary but not …
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Role of Abberant Proteolysis in the Pathogenesis of APL
Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear …
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The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis
… is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional …
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Regulation of NF-κB by PML and PML-RARα
… for the transactivation activity of NF-κB. Promyelocytic Leukemia (PML) is a nuclear protein that forms nuclear bodies (PML NBs), sub-nuclear structures that are associated with transcriptionally active genomic regions that have been implicated in multiple processes such as apoptosis, …
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Machine Learning Techniques for Augmenting Hematological Malignancy Diagnosis
… data used for this work are from patients with acute myeloid leukemia, but these ML algorithms can easily be extended to other indications. The ML models and techniques applied to cytogenetic micrographs and MFC data are predominantly of the deep learning variety, including convolutional neural …
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Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry
Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. The aims were to investigate: i) the incidence and survival of adult AL in regions with …
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Signal Regulation By Cd38, Lyn, And Mapk-Associated Molecules During All-Trans Retinoic Acid-Induced Differentiation Of Acute Myelogenous Leukemia Cells
… retinoic acid (ATRA) is successful in treating acute promyelocytic leukemia but has shown limited success with other cancers. Identifying signaling pathways that confer ATRA responsiveness and compounds that enhance the effects of the drug could expand its therapeutic efficacy. The leukocyte …
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Hypoxic Adaptation and Arsenic Trioxide Treatment in Small Cell Lung Carcinoma
… for patients with relapsed or refractory acute promyelocytic leukemia. Here, we demonstrate that As2O3 is cytotoxic to SCLC cells and xenotransplanted SCLC tumors at clinically relevant concentrations and the effect is also sustained at hypoxic conditions. Areas of low oxygen tensions, …
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Role of BTG2/TIS21/PC3 in differentiation of myeloid leukemia cells and its regulation under stress conditions
… of c-Myc transcription factor is common in leukemia and lymphomas; the tumors are highly proliferative and often blocked at an earlier phase than the terminal stage of differentiation. The interrelation and the functional interplay of these two different proteins are not defined yet. We have …
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Molecular Mechanisms of Growth Inhibition Mediated by Retinoic Acid in Human Pancreatic Cancer Cells
… has been in changing the clinical course of acute promyelocytic leukemia (APL), from a highly lethal disease to complete remission in >90% of cases after treatment. Promising results have also been obtained with 9-cis- retinoic acid in combination with tamoxifen in Phase I trials in breast …