Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"acute phase protein"”.
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Serum Lipocalin-2 (LCN-2) as a major acute phase protein under different pathological conditions in vivo and in vitro studies
… ist eine pleiotrope 25-kDa sekretorischen Proteins, das derzeit als Biomarker für Nierenschäden und Entzündungen eingesetzt. Sein Serumspiegel unter verschiedenen pathologischen Bedingungen erhöht, aber die Quelle und Ursache sind unklar. Das Ziel unserer Studie war es, zur prospektiven …
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Regulation of suppressor of cytokine signalling 3 expression by the pro-inflammatory cytokine (IL-1beta) in vitro and inflammatory stimuli in vivo
… of the organism. IL-6-induced expression of acute phase protein genes in the liver is tightly regulated through both IL-6-induced feedback inhibitors and the activity of pro-inflammatory cytokines such as tumor necrosis factor alpha and interleukin-1beta. In previous studies mechanisms of how …
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… of oxidative stress is the inflammatory acute phase protein response. Oxidative stress and its accompanied inflammation can be reduced via phase 2 enzyme induction. Broccoli sprouts, a rich source of phase 2 enzyme inducers such as isothiocyanates, can be incorporated into the diet to …
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Der humane lösliche Interleukin-6-Rezeptor: Reinigung aus Plasma, Charakterisierung und Nachweis der von einer alternativ gespleißten mRNA translatierten Form
… by its ability to induce the synthesis of the acute-phase protein alpha-1-antichymotrypsin. It was shown that the sIL-6R isolated from human plasma is recognized by an affinity-purified peptide antibody raised against an amino acid sequence unique for the alternatively spliced isoform.
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Repression der IL-6-Signaltransduktion über das zytoplasmatische Tyrosin 759 des Signaltransduktors gp130
… gp130 which have been described to recruit STAT-proteins are not equivalent in respect to their potential to activate STAT-factors, acute-phase protein gene promoters and in induction of proliferation. To investigate the potential of each tyrosine-motif add-back-receptor mutants were generated, …
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Physiological and Biochemical Aspects of Methionine Isomers and Precursors in Broilers
… activity, blood antioxidant profile (e.g., acute phase protein, leukocyte count), intestinal nutrient transporter gene expression, Met converting enzyme gene expression and activity, oxidative stress markers, and a potential pathway related to amino acid signaling. To achieve this goal, male …
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Modulation der IL-6-abhängigen Signaltransduktion durch die Protein-Tyrosinphosphatase SHP2
In the year 1993 a protein-tyrosine phosphatase, SH2 domain containing protein-tyrosine-phosphatase 2 (SHP2), has been discovered, which seems to play an important role in the signaltransduction of many cytokines. The aim of this work was to elucidate the role of the tyrosine phosporylation of SHP2 …
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Equine Septic Arthritis and Serum Amyloid A
… characterized by significant elevations in total protein (TP) and total nucleated cell count (TNCC). However, in some cases it can be difficult to distinguish between septic arthritis and non-septic joint inflammation (synovitis) based on clinical signs and synovial fluid cytology alone. A rapid …
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Characterising the role of haptoglobin in experimental subarachnoid haemorrhage.
… The role of haptoglobin (Hp), a systemic acute phase protein and the primary Hb-scavenging molecule, has recently been postulated to play a role in the pathogenesis of cerebral arterial vasospasm and delayed neurological deterioration in patients suffering SAH. The aim of this project was …
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Fetuin-A als Risikomarker bei Patienten mit Niereninsuffizienz : Nephelometrie als neues Nachweisverfahren bei Risikokollektiven
… in the serum. The calcification inhibiting protein ahsg/fetuin-a accounts for 50% of the precipitation inhibitory effect in serum and acts in vivo and in vitro. Additionally ahsg/fetuin-a is a negative acute phase protein whose concentration is downregulated during acute or chronic …
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Der Transkriptionsfaktor FKHR interagiert mit STAT-Faktoren und verstärkt die IL-6-Signaltransduktion
… but on the other hand reduce the synthesis of acute phase proteins in hepatocytes. This thesis will give a possible reason for this observation. An important pathway of signal transduction of growth factors depends on the activation of PI3 kinase and the ProteinkinaseB (PkB). Within the cell …
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SERUM AMYLOID A IN RUMINANTS: DIAGNOSTIC VALUE AND FOOD CONTAMINATION ASSESSMENT
… in this thesis were to investigate the bovine acute phase protein Serum Amyloid A, focussing on its value as safety marker in farm animals. SAA can be considered as a natural anti-inflammatory and immunomodulatory agent and local expression of SAA, at the site of the initial acute phase …
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Plasmatische und zelluläre, nicht invasive Biomarker für die Diagnostik kardialer Abstoßungsreaktionen
… markers of cardiac rejection. The search for protein markers in cardioplegia solutions revealed that increased activation of the complement system may occur in the context of primary graft failure. This assumption is supported by an increased presence of the acute-phase protein CRP. Platelets …
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The effects of E-cigarettes on pulmonary inflammation and inflammasome activation
… profile as measured by inflammatory cytokine and acute phase protein content. These data highlight that vaporisation of E-liquid produces vapours that are not benign to human cells and can cause inflammatory dysregulation.
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Mechanism of Transcriptional Regulation of C-Reactive Protein Gene Expression.
<p>C-reactive protein (CRP) is an acute phase protein produced by hepatocytes whose serum concentration increases in inflammatory conditions including cardiovascular complications. Statins that are used in the treatment of cardiovascular diseases to reduce cholesterol also lower serum CRP levels. …
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Analytical validation and evaluation of the effects of intramuscular injections on acute phase proteins in horses
Acute phase protein (APP) measurement can be used to characterize and detect inflammation, as well as monitor response to therapy. Intramuscular (IM) injections often result in local swelling and inflammation, which may lead to increased plasma concentrations of APP. The first objective of this …
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The plasma protein fetuin: common structural features of the mammalian fetuin family
… expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed. These probes were end-labelled using 14 polynucleotide kinase and …
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Molecular mechanisms in obesity-associated metabolic disease
… of obesity-associated metabolic disease. The acute-phase protein serum amyloid A (SAA) was unexpectedly found to be predominantly expressed in adipocytes during the nonacute-phase. Since SAA has been suggested to have multiple atherogenic effects, the production of SAA in adipose tissue may be …
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IDENTIFICAZIONE DI NUOVI BIOMARKER E METODI ANALITICI INNOVATIVI IN PATOLOGIA CLINICA VETERINARIA
… a probable biological behaviour as a negative acute phase protein. 3. Hypertension markers: homocysteine and entothelin-1 (ET-1). Hypertension usually is secondary to diseases that indirectly could affect the systemic pressure, mainly renal and heart diseases. Homocysteine appears increased in …
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STAT3-protein interactions in IL-6/gp130 signaling
… examined by using gamma-Fibrinogen (ã-FBG), an acute phase protein, as a model. IL-6 induces a strong nuclear association of STAT3 with CDK9, which is mediated via both STAT’s NH2-terminal and COOH-terminal domains. The induction of ã-FBG by IL-6 is significantly decreased when CDK9 is repressed …
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