Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"acute lung injury"”.
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Role of Soluble [alpha]-Klotho in the Alleviation of Acute Lung Injury
… our modern environment. These insults can cause acute lung injury (ALI), a syndrome characterized by inflammation, increased permeability, and pulmonary infiltrates. Moderate ALI causes hypoxemia, leading to respiratory failure if left unattended. Patients with severe ALI develop acute …
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Targeted Delivery of Surface Modified Nanoparticles: Modulation of Inflammation for Acute Lung Injury
… of pulmonary inflammation associated with acute lung injury (ALI) using novel surface modified nanoparticles. ALI is characterized by three main pathological events: I) pulmonary edema, II) excessive pro-inflammatory cytokines and chemokines production from alveolar epithelial and …
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Incidence and Pathogenesis of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Humans
Acute lung injury (ALI) and it’s more severe form, acute respiratory distress syndrome (ARDS), are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and …
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Role of Covalent Modification of Hyaluronan with Inter-Alpha Inhibitor Heavy Chains During Acute Lung Injury
… playing a critical role in tissue maintenance, injury, and repair. Hyaluronan (also known as hyaluronic acid, HA) is a ubiquitous ECM polysaccharide consisting of a repeating disaccharide backbone that can be covalently modified by the heavy chains (HC) of the serum protein inter-alpha-inhibitor …
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Mechanisms of imporvement following functional inhibition of nitrosative stress after brun and smoke-induced acute lung injury
… flame burn and smoke (B + S) inhalation induces acute lung injury (ALI) and results in the loss of pulmonary function. A cascade of molecular and cellular events initiates the formation of reactive oxygen/nitrogen species (ROS/RNS) that in turn drives an inflammatory response and consequently …
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Lung mechanics in the aging lung and in acute lung injury. Studies based on sinusoidal flow modulation.
Knowledge about lung mechanics is of interest in intensive care to adjust mechanical ventilation and in the lung laboratory for diagnostics and evaluation of patients with various kinds of respiratory diseases. In mechanical ventilation a single inspiratory elastic pressure-volume (Pel/V) curve is …
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Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury
… significant tissue damage and worsening of the acute inflammatory event as well as long term tissue injury, scarring and fibrosis. One such pulmonary condition is acute respiratory distress syndrome (ARDS) which, despite decades of intensive research and multiple clinical trials, remains without …
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Lung microenvironment plays a key role on the protective vs. detrimental effects of mesenchymal stromal cell therapy in acute lung injury
Acute respiratory distress syndrome (ARDS) is a complex disorder with high mortality. Most ARDS non-survivors present complications of pulmonary fibrosis. Mesenchymal stromal cells (MSC) are considered good candidates for therapy due to their ability to home into injury sites and help in recovery. …
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Staphylococcal Enterotoxin B-Induced Acute Lung Injury:Mechanism and Treatment of Disease
<p>Acute lung injury (ALI) remains as an important health condition in intensive care units all over the world, with approximately 200,000 cases per year in the United States only. ALI can develop as a medical complication following inhalation of a toxic substance, septic shock, blood transfusions …
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Acute pancreatitis, from local defense to remote organ injury
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung …
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Losartan, an angiotensin II receptor blocker, fails to attenuate pulmonary dysfunction in ovine burn and smoke model
Elevated levels of angiotensin II (AngII) in the lung have been shown in response to burn and smoke inhalation injury. AngII has been associated with increased nitric oxide levels, leading to nuclear oxidative damage in Type II lung epithelial cells. Losartan is an AngII, AT1A specific receptor …
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Der Sauerstoffverbrauch der Lunge (VO2pulm) bei Patienten mit Acute Lung Injury (ALI) und Acute Respiratory Distress Syndrome (ARDS) unter mechanischer Beatmung und PEEP-Variation, gemessen als VO2-Differenz zwischen indirekter Kalorimetrie und Berechnung über das inverse Fick´ sche Prinzip
Bei Patienten mit einem akuten Lungenversagen (ALI oder ARDS) ist der Sauerstoffverbrauch der Lunge (VO2pulm) durch pathophysiologische Prozesse insbesondere die Ausbildung von Atelektasen stark beeinträchtigt. Aufgrund der Annahme, dass eine Steigerung der Anzahl ventilierter Lungenareale zu einer …
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by diffuse alveolar damage, pulmonary edema, and severe hypoxemia, with limited therapeutic options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… resolution (5-day) phases of acrolein-induced acute lung injury, incorporating both sex and age as key biological variables and potential determinants of the severity of the response. At the 24-hour timepoint, single-cell RNA sequencing, bronchoalveolar lavage (BAL) cytokine profiling, and …
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The Role of A2B Adenosine Receptor Signaling In Adenosine Dependent Lung Disease
Chronic lung diseases and acute lung injuries are two distinctive pulmonary disorders that result in significant morbidity and mortality. Adenosine is a signaling nucleoside generated in response to injury and can serve both protective and destructive functions in tissues and cells through …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by …
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High-throughput platforms for investigating bioadhesion and cell migration
… on endothelial wound healing relevant to acute lung injury.
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Development of versatile drug delivery strategies using PLGA nanoparticles
… of a novel anti-inflammatory therapy to treat acute lung injury and the more severe acute respiratory distress syndrome. 02-8-NANA conjugated NP demonstrated RAW 264.7 monocyte cell targeting and internalisation. Co-incubation of these particles in RAW 264.7 cells induced inhibition of the LPS- …
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A retrospective audit of the clinical value of routine chest radiographs in the first 24 hours after cardiac surgery using medical records
… main culprit [Milot J et al, 2001] - leading to acute lung injury. Over and above the usual cardiovascular diseases that require surgical intervention, in Sub-Saharan Africa, inflammatory and infective conditions such as pulmonary tuberculosis, pulmonary hydatid disease, and pulmonary …
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