Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"acute liver injury"”.
-
Ο ΡΟΛΟΣ ΤΟΥ ΧΡΟΝΟΥ ΕΦΑΡΜΟΓΗΣ ΤΟΥ ΠΡΟΑΓΩΓΟΥ ΠΑΡΑΓΟΝΤΑ ΣΤΗ ΧΗΜΙΚΗ ΔΙΦΑΣΙΚΗ ΚΑΡΚΙΝΟΓΕΝΕΣΗ ΤΟΥ ΒΛΕΝΝΟΓΟΝΟΥ ΤΟΥ ΣΤΟΜΑΤΟΣ. ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΣΕ ΛΕΥΚΟΥΣ ΕΠΙΜΥΣ
… CARCINOGEN (NMU - 50MGR/KGBW). IN THESE ANIMALS ACUTE LIVER INJURY WAS INDUCED BY INJECTION OF D- GALACTOSAMINE (200 MGR/KGBW). CONTINUOUS CHRONIC, NON-SPECIFIC, MECHANICAL IRRITATION WAS APPLIED ON THE LEFT BUCCAL MUCOSA, 7 DAYS BEFORE (GROUP 1) THE FIRST INJECTION OF NMU, AS WELL AS 16 DAYS …
-
Manipulating macrophages to enhance liver regeneration
Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic …
-
Effect of pumpkin seed (cucurbita pepo) protein isolate on the antioxidant enzymes in ccl4-induced liver injury in low-protein fed rats
… (ALP) against carbon tetrachloride (CCU)-induced acute liver injury in low-protein fed rats were investigated. A group of male Sprague-Dawley rats which were maintained on a low-protein diet for five days were divided into three subgroups. Two subgroups were injected with carbon tetrachloride and …
-
Modelling human liver bud development in vitro
… the structural complexity of the developing liver bud. This includes a ‘bud’ containing hepatoblast progenitors (ALB+AFP+HNF4A+), and a ‘trunk’ containing hepato- pancreato-biliary progenitors (KRT19+CDX2+PDX1+HNF1B+) and extra-hepatic cholangiocytes (ACE2+MUC13+). By performing extensive …
-
Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
At present, Drug-Induced Liver Injury (DILI) is the most frequent cause of acute liver injury, with an incidence ranging from 0.023-1.5‰ in developed countries. DILI can be separated into two different types. Whereas intrinsic DILI concerns predictable dose-dependent hepatoxicity, idiosyncratic …
-
Investigations on the antifungal and cancer modulating properties of extracts from selected species of Tulbaghia
… (ELEM), porcine pulmonary edema (PPE), liver toxicity in several animals and esophageal and liver cancer in humans. In one of our studies we hypothesize that aqueous extracts of indigenous South African wild garlic species (Tulbaghia violacea, T. alliacea and T. simmleri) may enhance the …
-
Development of circulating microRNA in drug-induced liver injury: studies in humans and zebrafish
… biomarkers in patients with paracetamol-induced liver injury. Whether the miRNAs discovered in humans could be back-translated to zebrafish with the aim of developing a liver toxicity model to replace rodent use was also investigated. First, the miRNA signature of DILI induced by paracetamol was …
-
ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial …
-
Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… 70% of retinoid in the body is stored in the liver, and, of this fraction, 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for …
-
THE ROLE OF NRF2 IN PREVENTING OXIDATIVE/ELECTROPHILIC STRESS-INDUCED LIVER INJURY
… ten years, but the global Nrf2 target genes in liver still remain unknown. The present dissertation utilizes a Nrf2 "gene dose-response" model to genetically modulate the levels of Nrf2 in mouse liver, where the transcription profiles in livers of mice with graded Nrf2 activation were correlated …