Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"acute leukemias"”.
-
CHILDHOOD ACUTE LEUKEMIAS IN SINGAPORE
Acute leukemia is the major form of malignancy in children. Acute leukemia includes a heterogeneous group of malignant diseases derived from transformed haematopoietic progenitors at various stages of differentiation. Research in acute leukemia involves a very broad spectrum of topics, which can be …
-
Mapping the therapy resistance landscapes of acute leukemias using in vivo functional genomics
The recurrence of therapy resistant disease remains an intractable problem in oncology clinical care. To address this issue, investigators have traditionally focused on elucidating cell-intrinsic mechanisms that render tumors refractory to both classical chemotherapeutics and targeted agents. …
-
Population-based studies on acute leukemias - lessons from the Swedish Adult Acute Leukemia Registry
Acute leukemia (AL) is a rare, potentially curable, aggressive neoplasm of hematopoietic origin. AL is a heterogeneous disease and is further subdivided according to clinical and biological features. The aims were to investigate: i) the incidence and survival of adult AL in regions with …
-
An integrative bioinformatics approach to characterize molecular landscapes and clinical outcomes in acute leukemias
Acute leukemias are biologically and clinically heterogeneous hematologic malignancies. This dissertation examines this heterogeneity at three levels: population-based disease patterns, RNA-seq-based molecular classification, and developmental interpretation. First, nationwide German cancer …
-
THE NOVEL GEMCITABINE PHOSPHOLIPID CONJUGATE KPC34 HAS ACTIVITY AGAINST MULTIPLE MODELS OF RESISTANT ACUTE LYMPHOBLASTIC LEUKEMIA
Acute leukemias are cancers of the blood and bone marrow that affect thousands of Americans annually. These diseases can be myeloid or lymphoid in origin. Common components of therapy for both types of disease involve cytarabine and an anthracycline. After initially responding to treatment, most …
-
Flow cytometry in the diagnosis and prognosis of canine lymphoma and leukemia
… and clinical features of canine CD34+ acute leukemias. Flow cytometry data, CBC and blood film evaluation from 11 dogs with CD34+ acute leukemia were compared to 11 dogs with CD34- acute leukemia in order to identify qualitative differences in terms of cellular morphology, degree of …
-
Anc1 : a new player in the cellular response to DNA damage
… in the MLL gene fusions associated with human acute leukemias. Here, we show that ANC1 falls into the same genetic pathway as several members of the postreplication repair (PRR) pathway, but has additive or synergistic relationships with other members of the pathway. Based on our epistasis data …
-
Aberrante DNA-Methylierung des Transkriptionsfaktors C/EBP[alpha] bei akuter myeloischer Leukämie
… region near the transcription start site in acute myelogenous leukemia (AML). Aberrant methylation of the C/EBP alpha promotor region was found in 10/80 (12,5%) primary samples from AML in the French-American-British (FAB)-subtypes M1, M2, M4, M4eo und M5. Moreover hypermethylation was …
-
Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia
… assessed the role of S6K1 in the propagation of acute myeloid leukemia (AML). The mixed-lineage leukemia (MLL) gene is required for the maintenance of adult HSCs. Translocations in MLL are detected in approximately 5-10% of adult acute leukemia patients and in approximately 70% of acute …
-
Herstellung und Validierung von Tissue Microarrays von Knochenmarkbiopsien
… literature. In our study we include 148 cases of acute leukemia, which comprise 115 AML (according to the FAB classification: 10 M0, 12 M1, 30 M2, 5 M3, 29 M4, 15 M5, 1 M6, 2 M7 und 11 not classified) and 33 ALL (23 B- and 5 T-ALL, 5 not classified). Some cases were punched twice, the others three …
-
INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS
… expression and prognostic role of CD47 in canine leukemias, and (3) the characterization of lymphocyte populations in peripheral blood and sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, the project evaluated the expression of the surface membrane protein …
-
Transcriptional Regulation of the Metabolic Response to Therapy in Leukemia
… of the response to asparagine deprivation in acute lymphoblastic leukemia (ALL). We found that under asparagine depleted conditions ZBTB1 enables cellular proliferation by promoting the synthesis of asparagine from aspartate. Mechanistically, ZBTB1 binds directly to a sequence within the …
-
A Study of the Therapeutic Potential of AF4 Mimetic Peptides
<p>Mixed lineage leukemias (MLL) are a group of acute and aggressive leukemias. They account for over 70% of infant leukemias, and 10% of acute adult leukemias. Pediatric ALL and therapy related MLL leukemias carry poor prognosis in spite of several advancement in the field of leukemia research. …
-
The Role of Cyp33 in MLL Mediated Gene Repression
… whose gene is translocated in a subset of AML leukemias. Translocation of the MLL gene is present in approximately five percent of adult acute leukemias and ten percent of pediatric leukemias (Daser, A 2004, Look, A 1997, Huret, J 2001) Patients presenting in the clinic at the time of diagnosis …