Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"acute ischaemic stroke"”.
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Hyperglycaemia, insulin and acute ischaemic stroke
Background: Hyperglycaemia is common in acute stroke and is associated with a poor outcome. Underlying aetiology and mechanism of action is poorly understood. Management remains uncertain. Methods: We undertook a randomised placebo controlled trial to assess the effect of GKI …
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Characterising the role of substance P in acute ischaemic stroke.
… than 15 million people worldwide will suffer a stroke each year two thirds will die or be left permanently disabled. Accordingly, stroke represents an enormous financial burden on the community, due to the cost of hospitalisation, treatment and rehabilitation of stroke patients. Despite the …
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The viral protein R in HIV-associated acute ischaemic stroke: a case-control study
… dysfunction, which is a major determinant of ischaemic stroke risk in HIV-infected individuals. Polymorphisms in HIV-1 viral protein R (Vpr) may alter its potential to promote endothelial dysfunction, by modifying its effects on viral replication, reactivation of latent cells, upregulation of …
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Early outcomes of thrombolysis for acute ischaemic stroke in a South African tertiary care centre
Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. This prospective observational study was designed to …
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Role of non-enhanced CT characteristics for differentiating reversible and irreversible brain tissue injury and estimating the tissue fate in acute ischaemic stroke
… or an unknown time of onset following an ischaemic stroke has largely been based on advanced imaging techniques such as CT perfusion and MRI. However, the universal availability of these techniques is limited. Non-enhanced computed tomography (NECT) is the most widely accessible imaging …
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The role of the HIV-1 Tat protein in acute stroke: more than just a transactivator of transcription?
… virus (HIV) are at increased risk of developing ischaemic stroke. The reasons for this are multifactorial, but HIV-associated vasculopathy is a potentially important cause. HIVinduced chronic inflammation may initiate endothelial dysfunction or accelerate vascular injury from other disease …
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Outcomes of mechanical thrombectomy at a single-centre tertiary level public health care hospital in South Africa
… thrombectomy (MT) is standard of care for acute ischemic stroke from large vessel occlusion following randomized controlled trials performed largely in high-income countries. Limited data exists on its effectiveness in the real-world setting, particularly in low- and middle-income …
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Investigating white matter alterations and secondary neurodegeneration with MRI imaging and pathology in a mouse model of ischaemic stroke
Advances in acute ischaemic stroke treatment have increased survival rates, yet many individuals experience long-term complications such as post-stroke cognitive impairment and dementia. While the primary infarct is well characterised, the mechanisms driving chronic degenerative changes in remote …
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Treatment of brain cancer and ischaemic stroke utilising High Intensity Focus Ultrasound (HIFU) guide with MRI
… cancer treatment (thermal mode) and treatment of ischaemic stroke (mechanical mode). These two applications were investigated in vitro and in vivo models. MRI was utilized to monitor the lesions created by HIFU either in thermal or cavitation mode in freshly excised lamb brain tissue in vitro, and …
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The role of regulatory T cells in stroke recovery
Background: Acute ischaemic stroke is a major cause of mortality worldwide. Despite the search for new therapies, tissue plasminogen activator remains the only FDA-approved medication. The immune system is involved in all stages of stroke, from risk factors to pathogenesis and tissue repair. The …