Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"acute exposure"”.
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Morphometric changes in the prepubertal rat thyroid gland following acute exposure to PCBs
Female rats subjected to a short-term immature rodent bioassay, developed to study the effects of polychlorinated biphenyls (PCBs), were further used to examine the effects of PCBs on thyroid glands through examination of serum thyroxine (T$\sb4$) and morphometry.
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Computer vision enabled approaches to predicting responses to fluctuating temperatures in aquatic embryos
… as that the physiological effects of chronic and acute exposure are equivalent. A key limitation in prior empirical studies assessing rate summation is in the assessment of single endpoints, and not in the responses that lead to those endpoints, thereby concealing the drivers behind discrepancies …
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MUNC13 PROTEINS REGULATE STRAIN-DEPENDENT EFFECTS OF ETHANOL-MEDIATED INHIBITION OF SYNAPTIC VESICLE RECYCLING
… Our lab has previously demonstrated that chronic exposure to alcohol and subsequent withdrawal leads to long-term adaptations in glutamatergic transmission within the basolateral amygdala (BLA). We have also demonstrated that this hyperexcitable state contributes to the expression of withdrawal …
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Exposure to Synthetic Antioxidants Disrupt Early Development in the Frogs Silurana Tropicalis and Lithobates Pipiens
… released into the environment yet their toxic acute and chronic effects on humans and wildlife are not well understood. Some of these chemicals behave as endocrine disruptors (EDCs), altering development in many wildlife species including amphibians, which are sensitive to these compounds. …
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A nested case-control study of lung cancer and central nervous system neoplasms among chemical workers
… on area of employment and on potential exposure to certain chemicals was obtained from plant personnel and medical records and from interviews with knowledgeable long-term employees. Information on potential confounders, including cigarette smoking, was obtained by interviewing study …
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The Effects of Chronic Nitrite Exposure on Tissue Morphology and Physiology in Xiphophorus couchianus
… and morphological damage in aquatic species in acute, short term, exposures. However, it is unknown how chronic exposure to contemporary water nitrite concentrations can affect fish physiology. Moreover, there is a lack of current knowledge on how nitrite effects maternal health and, …
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Pathophysiological changes in cardiomyocyte metabolism and bioenergetics during stress-induced cardiomyopathy.
… changes in cardiomyocytes during stress exposure. Stress exposure leads to pathophysiological changes in myocardium, which can lead to heart failure. It is important to know exact pathophysiological changes to prevent the development of heart failure. The main aim of this thesis was to …
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Effects of ibuprofen on Rainbow Trout (Oncorhynchus mykiss) following acute and chronic waterborne exposures
… purpose of this experiment was to determine the acute and chronic effects of ibuprofen on rainbow trout (Oncorhynchus mykiss). Cyclooxygenase (COX) activity, vitellogenin (VTG) concentration and ethoxyresorufin-O-deethylase (EROD) activity were evaluated following waterborne ibuprofen exposure of …
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The Impact of Gamma Stimulation on Neurological Phenotypes of Alzheimer's Dementia and Down Syndrome
… outcomes in patients with mild AD during acute and chronic exposure to GENUS. Additionally, due to the increase in amyloid burden and other shared biological and cognitive phenotypes present in the setting of trisomy 21 compared to AD, we also present initial investigation into the use of …
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Design & application of novel methods of analysis for monitoring marine biotoxins
… whereby action limits have been established for acute exposure. Nonetheless the common symptoms are vomiting and diarrhoea which in cases of mild intoxication can be misdiagnosed as bacterial or viral food poisoning. To date there are limited diagnostic tools available for application by all …
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Satellite constraints on surface concentrations of particulate matter
… widespread adverse effects on human health from exposure to poor air quality and the recommendations of the World Health Organization to significantly reduce PM2.5 in order to reduce these risks, better estimates of surface air quality globally are required. However, surface measurements useful …
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Predictors of Hyperkalemia and Outcomes of Dyskalemia in US Veterans with Advanced Chronic Kidney Disease Transitioning to Dialysis
… of baseline time-averaged K+ levels (distant exposure) and time-updated K+ levels (acute exposure) (both categorized as hypokalemia [K+ 5.5 mEq/L] and referent [3.5 mEq/L ≤ K+ ≤ 5.5 mEq/L]) with time to first ischemic stroke using Cox regression models. Finally, for Aim 3 (Chapter 4), we …
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Physiological evaluation of sleep surfaces in healthy volunteers and patients with acute-upon-chronic lower back pain
… HR over the 30 minute period was lower after acute exposure to the LBS+ CM (60 ± 11 b/min) compared to the CM (66 ± 10 b/min, p < 0.05; LBS+ CM vs. CM). Although average HR response to the LBS+ CM was lower compared to CFS + CM (64 ± 9 b/min), this difference was not significant. ROD reported …
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Numerical modeling of agricultural tile drainage water quality with health considerations
… regardless of the method of application, but acute exposure incidents are highly rare. Literature was reviewed to determine the common stressors and agents of injury for agricultural applicators. Additionally, the ensuing fate of nitrate in the environment and drinking water system was …
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Sublethal effects of an acetylcholinesterase-inhibiting pesticide on fitness-related traits in the western fence lizard (Sceloporous occidentalis)
… in energy allocation. My findings suggest that acute exposure to high concentrations of carbaryl can have important sublethal consequences on fitness-related traits in S. occidentalis. Future studies should examine the consequences of multiple-pulse exposures to AChE-inhibiting pesticides on …
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Characterization of the Molecular Mechanisms of Xenobiotic-Induced NRF2 Activation for Disease Prevention and Intervention
… of the cellular antioxidant response upon exposure to xenobiotics. In addition, NRF2 induces the expression of genes involved in drug metabolism, protein homeostasis, anabolic metabolism, inflammation, proliferation, and survival. Understanding the molecular mechanisms of xenobiotic-induced …
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Alterations In The Mouse Striatum Following Acute And Repeated Ethanol Exposure
… both voluntary ethanol consumption along with acute exposure to ethanol via systemic injection several striatal alterations were observed. Seven days of voluntary binge-like ethanol consumption produce a tolerance to ethanol stimulation of DA release, which could be mediated by alterations in …
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Psychoneuroimmune Implications of Non-Infectious Neuroimmune System Activation and the Impact of Type 2 Diabetes
… including the psychoneuroimmunological impact of acute cerebral hypoxia. Chapters 2 through 4 establish that (1) IGF-1 and vanadyl sulfate speeds recovery from lipopolysaccharide-induced neuroimmune system activation, while only vanadyl sulfate is effective in the db/db mouse model of type 2 …
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Environmental risk management of contamination of marine biota by hydrocarbons specifically those arising following an oil spill.
… but differed from those evaluated from acutely exposed mussels. Shorter t1/2 were obtained from acutely exposed mussels. The t1/2 ranged between 0.5- 22 d (acute exposure) and 3.8- 31.5 d (chronic exposure).The longer apparent t1/2 calculated for the chronically impacted mussels was …
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The neurotoxic effects of Manganese and the novel protective role of Drp1 in the autophagy pathway
… assessed in these cellular contexts following Mn exposure. Acute exposure to sub-lethal Mn concentrations, in vitro and in vivo, caused an inhibition of autophagy flux in the absence of mitochondrial dysfunction. Despite this, Drp1 inhibition improved Mn-induced autophagy impairment and reduced …
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