Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"activity-dependent release"”.
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… is secreted from DCVs in response to synaptic activity. Indeed, by stimulating synaptic activity in motorneurons using two independent measures, high K+ depolarization and by activating the blue light-gated cation channel, channelrhodopsin, in motorneurons, we detect activity-dependent changes …
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Spontaneous and evoked vesicle cycling at a presynaptic terminal
… the post-synaptic membrane. To sustain neuronal activity, vesicles are then retrieved by endocytosis and refilled with neurotransmitters for further rounds of release. Neurotransmitter release can also occur spontaneously in the absence of action potentials. The current assumption is that both …
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Influence of Brain Derived Neurotrophic Factor and Family History of Alcohol Dependence on Alcohol Use in Healthy Social Drinkers
… BDNF gene, a genotype associated with decreased activity-dependent release of BDNF. However, the literature remains contentious with regard to this issue. The current study was designed to address this issue with two aims. Aim 1 examined the influence of the Val66Met SNP and family history of …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… an essential role in brain communication via the activity-dependent release of neurotransmitters. This is made possible by exocytosis of synaptic vesicles (SV) that package the neurotransmitters, and these SVs are recycled via endocytosis. However, the sequence of events through which a presynapse …
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Gene therapy for epilepsy: resculpturing synaptic transmission with neuropeptides
… know under which circumstances transgene NPY is released, and whether and how it acts on synaptic transmission within the area of viral vector transduction. In this thesis, evidences are provided showing that NPY is mediating its antiepileptic effect through activation of both Y2 and Y5 receptors …