Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"activity-based profiling"”.
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Activity Based Profiling: New Insights into Metabolic Homeostasis
… nervous system using phosphorylated ribosome profiling. I will use this method to identify new neuronal populations that regulate energy balance as well as uncover new functions for well-studied neural populations. I will elaborate on key findings such as the role of prodynorphin, …
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Biased Constitutive Activity in the Uveal Melanoma Oncogene CYSLTR2 is Unique in CYSLTR2 Germline and Pan-Cancer Human Variome
… been hypothesized to result from constitutive activity, but how the receptor could escape desensitization is unknown. In this work, we characterized the functional properties of CysLTR2-L129Q. CysLTR2 signals through the Gq/11/PLC-β pathways, so using a homogenous time resolved fluorescence …
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Chemical Tools for Exploring Metabolite Interactions with Nuclear Receptors and Beyond
… can be challenging and limiting. In this regard, activity-based protein profiling (ABPP) using active site–directed probes in combination with small molecule competition studies allows the discovery of potential substrates and inhibitors of selective enzyme families. Moreover, the development of …