Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"activity modulation"”.
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Minimally invasive neuromodulation using mechanically-sensitive ion channels and magnetically-actuated nanotransducers
Traditional methods of neuronal activity modulation, like pharmacological interventions and noninvasive techniques such as transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) have limitations in specificity and penetration depth. Deep brain stimulation (DBS), …
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Allocation of Computational Resources in the Nervous System.
… We continue by discussing the attentional modulation of neuronal activity, and showthat: (1) Modulation of coding strategies does not require special mechanisms: it is possible to obtain dramatic modulation even when signals informing the system about fidelity requirements enter the system …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… Research has also demonstrated that neuronal activity plays a central role in early myelin development and promotes oligodendrogenesis and adaptive myelination. Thus, it becomes important to understand how neuronal activity affects myelin. In this thesis, the role of neuronal activity in …
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Role of N-Terminal Region in Modulating RNA Binding Activity of the La Module in Vertebrate LARP6
… of LARP6 appears to play a role in RNA binding activity and specificity, as well as being suspected of interacting with the La Module domain. To further explore the effect of the NTR on the overall RNA-binding function of the protein, we created five protein constructs with the zebrafish model …
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Reconstituting APP and BACE in proteoliposomes to characterize lipid requirements for β-secretase activity
… mechanisms, access to substrate and direct activity modulation, can be determined by the lipid composition of the membrane. Integral membrane proteins (like APP and BACE), can be viewed as solutes in a two-dimensional liquid membrane, and as such their state, and biological activity, …
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Escape to the interior: Characterization of the cytosolic delivery of C-terminal cargo subdomains by the N-terminus of pasteurella multocida toxin and subsequent toxin-mediated downregulation of Gaq-PLCb1 signaling through depletion of Gaq from the plasma membrane
… and C3 contains the enzymatic deamidase activity that converts an active-site glutamine residue into glutamic acid in specific Gα-proteins. What is not clearly understood is whether the three C- terminal cargo subdomains are delivered intact or undergo proteolytic cleavage between each …