Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"active targeting"”.
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Development of a click chemistry approach for cancer cell targeting and evaluating the effect of protein corona on active targeting yield
The routine approach for targeting nanoparticle delivery vehicles to cancer cells is by incorporating targeting ligands (e.g. antibodies or aptamers) to the surface of nanoparticles (NPs). Although targeting ligands are known to interact with specific receptors in the membranes of cancer cells, …
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Design of Functional Polymeric Micelles as a Carrier for Anticancer Drug Delivery
… and in vivo cancer models. Functional groups for active targeting to tumor tissues were also assessed. The functionalized polycarbonate-based polymeric micelles successfully demonstrate its potential as a desirable drug delivery carrier.
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RGD-targeted Solid Lipid Nanoparticles Containing Asiatic Acid for the Treatment of Cancer
Selective anti-cancer treatment and targeting is needed to help minimise unwanted side-effects from conventional chemotherapy. Advanced drug delivery systems (DDSs) that have the potential for passive and active targeting have been of significant interests in the past decades, particularly with the …
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The development of next-generation antibody based therapeutics for the treatment of pancreatic cancer
… into nanomedicine platforms as both targeting ligands and effector molecules, to facilitate both improved drug delivery and synergistic signalling for enhanced disease control via ‘active targeting’.<br/><br/>This thesis attempts to develop and validate novel antibody conjugated, …
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Investigating the Receptor Interactions and Mechanisms of a Folic Acid-Conjugated Nanoparticle in the Treatment of Breast Cancer
… the treatment of cancer. However, the selective targeting and choosing the right cancer surface biomarker are critical for targeted treatments to work. The folic acid receptor alpha (FRα) has gained popularity as a potential target in triple-negative breast cancer (TNBC). We have previously …
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Development of Iron Oxide Based Nanoparticles as Dual-Modality Imaging Probes
… which is advantageous for both passive and active targeting. Due to its optimal tissue distribution pattern, NUSPION-1 was chosen for further in vivo evaluation in PC-3 tumor-bearing mice. High tumor uptake and contrast ratios of tumor-to-muscle and tumor-to-blood were observed. A …
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RGD based peptide amphiphiles as drug carriers for cancer targeting
… with receptors is one of the approaches for active targeting of anticancer drugs to cancer cells. Over expression of integrin receptors is a physiological manifestation in several cancers and is associated with cancer progression and metastasis, which makes it an attractive target for cancer …
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Redox-active Liposome Delivery Agents With Highly Controllable Stimuli-responsive Behavior
… has been met with two possible solutions: (1) active targeting and (2) active triggering. To achieve selective and site-specific delivery of drugs to tumors, active triggering methods have been developed wherein a responsive element is incorporated into the liposomal bilayer, which causes …
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The development of a radiolabelled macromolecule as a therapeutic agent for the treatment of cancer
… macrocycle (cyclam), ii) lead to passive tumour targeting via the EPR effect and a suitably large carrier such as human serum albumin and iii) induce active targeting through a glucose moiety recognised by the over-expressed glucose transporters on the surface of highly metabolically active …
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Cationic, α-helical polypeptides for cell penetration and non-viral gene delivery
… target polypeptide, which could facilitate the active targeting to the cells via the mannose-receptor mediated targeting, and the membrane active polypeptide, which could penetrate the cell membrane and allow the efficient gene delivery. Then, I use the chemical modification method to modify the …
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Novel approaches and pharmacological considerations in melanoma treatment
… that block tumour growth in patients with active BRAF mutations. Although these therapies offer significant improvement in treating melanoma patients, they are associated with high toxicity and drug resistance.<br/><br/>Nano-medicine offers unique advantages in treating metastatic melanoma. …
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Functionalized polypeptide- and lipid-based nanoparticles - synthesis and applications
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Design, Development and Evaluation of Erlotinib-Loaded Hybrid Nanoparticles for Targeted Drug Delivery to NonSmall Cell Lung Cancer
… increasing therapeutic efficacy and reducing off-targeting toxicities of ETB to healthy cells. In this work, a unique nanoparticulate carrier termed as CSLAHNPs was used for targeted delivery of ETB. The CSLAHNPs system was composed of albumin core and phospholipid bilayer shell. For active …
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Therapeutic Effects and Targeted Delivery of Eupenifeldin in Castration-Resistant Prostate Cancer
… was accompanied by a substantial increase in reactive oxygen species (ROS) production, further contributing to cellular damage and apoptosis. The addition of a ROS scavenger partially rescued cell viability, confirming the role of oxidative stress in Eupenifeldin’s mechanism of action. To …
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Targeting Nanoparticles to Tumor Vasculature
Targeting tumor vessels represents an indirect therapeutic approach in oncology by shifting the treatment away from the tumor cells themselves. Endothelial cells are generally considered genetically stable and do not use escape mechanisms against chemotherapeutic agents as frequently as tumor cells …
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Hybrid Nano-systems Based on PEGylate Porphyrins: Synthesis, Characterization and Theranostic Applications
… considered to be relatively biologically non-reactive and therefore suitable for in vivo applications. Other advantageous qualities include the strong optical properties of AuNPs due to localized surface plasmon resonance (LSPR), easily controllable surface chemistry which enables versatility in …
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Bioactivity and Cell-Mediated Targeting of Multistage Nanoporous Silicon Particles
… factor receptor 2 (VEGFR2) to enhance vascular targeting and relying on the natural tumor tropism of mesenchymal stem cells (MSC) to achieve dynamic targeting were investigated. Briefly, successful modulation of the release kinetics was achieved by adjusting the pore size of NSP regulated by the …
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Synthesis, characterization and applications of peptide-coated nanoparticles
… phenylalanine) FFF motif on the NPs surface, and active tumor/vasculature targeting through v targeting motifs. This thesis describes NPs with three different peptide coatings: 1) RGDFFF to target vasculature via RGD, 2) NGRFFF to target vasculature NGR, and 3) EKHFFF to target low pH of the tumor …
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Developing a Drug Delivery System for Treatment of Vocal Fold Scarring
… This knowledge is critical in developing bioactive materials that, when implanted into sites of tissue damage and scarring, direct cells to regenerate healthy tissues with normal ECM ratios and morphologies. Next, we moved on to developing our drug delivery system initially utilizing a …
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