Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"activation induced cell death"”.
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Cell Biology of Foxp3+ Regulatory T Cells
<p>T cells play a central role in the immune response to fight against pathogens and orchestrate other immune cells. An overreactive immune response can lead to autoimmune diseases, therefore the immune system must possess negative regulation mechanisms. In the periphery, naturally arising …
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Regulation and function of hyaluronan binding by CD44 in the immune system
The proteoglycan CD44 is a widely expressed cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan, and is involved in processes ranging from metastasis to wound healing. In the immune system, leukocyte activation induces hyaluronan binding through changes in CD44 …
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The role of Wilms’ Tumor gene product (WT1)in CD95-mediated apoptosis in T-cell leukaemias
Abstract Apoptosis, also known as programmed cell death, is a very critical process for the maintenance of tissue homeostasis in multicellular organisms. In our immune system, which is comprised of different cell types with different but interconnected functions, apoptosis plays a crucial role in …
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T cell phenotyping of a mouse model of Activated PI3Kdelta syndrome
… and herpes group virus infections. Following T cell receptor (TCR) stimulation, T cells from these patients undergo increased activation induced cell death, which can be reversed by selective PI3Kdelta inhibitors. I used a new conditional knock-in mouse (T-p110delta E1020K) in order to …
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Molekulare Mechanismen der Regulation des Aktivierungs-Induzierten Zelltods (AICD) in peripheren T-Zellen
… zu Aktivierungs-induziertem Zelltod (engl.: activation-induced cell death, AICD). In vitro führt die Reaktivierung von T-Zellen zur Expression von CD95L, mit der Konsequenz, daß benachbarte CD95-positive Zellen eliminiert werden, oder die T-Zellen Suizid begehen. AICD ist ein wichtiger …
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The Safety and Immunostimulatory Properties of Amorphous Silica Nanoparticles <10 nm in Diameter
… have already been conducted to evaluate the cellular toxicity of these silica particles but still little is known about their effects both in vitro and in vivo, especially of nanosilica particles under 10 nm in diameter. The aim of this thesis was to investigate the cellular and in vivo …