Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"activated protein C"”.
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Arterial Thrombosis in Factor V Leiden or Activated Protein C Resistance. Clinical and Experimental Studies.
… has seen an avalanche of studies establishing Activated protein C (APC) resistance due to Factor V Leiden mutation as the most prevalent genetic risk factor, yet known, for venous thromboembolism. This has been documented in 20-60% of patients with deep vein thrombosis (DVT). Whether such …
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ASPECTS OF FLUID THERAPY: An experimental study of the effects of systemic inflammation, microvascular permeability, blood pressure and plasma volume
… It also evaluated and compared the ability of activated protein C and prostacyclin to counteract an increased protein leakage in septic inflammation. Plasma volume expanding capacity of currently used colloid solutions was evaluated in standardized models of hypovolaemia. Plasma volume was …
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Staphylococcus aureus virulence factors dictate host signaling pathways and immune responses
… increased thrombomodulin expression by MEC and activated protein C (APC) production. APC inhibited PMN chemotaxis. Findings depicted an indirect role for VF on PMN responses, so next we determined signaling pathways and cytokine responses of PMN to S. aureus toxins. Live S. aureus infections …
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The regulation of blood coagulation by high-density lipoprotein particles
High-density lipoprotein (HDL) has anti-atherogenic properties and the plasma level of HDL cholesterol correlates inversely with the risk of coronary artery disease. The atheroprotective functions of HDL can be explained by its function in the reverse cholesterol transport. Blood coagulation is …
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Studies of Coagulation and Fibrinolysis
… for Arg320 cleavage. Third, the kinetics of activated protein C (aPC)-mediated inactivation of FVa in real-time, during prothrombin activation was investigated. A profound protection of FVa from aPC was observed (>100-fold), which was much greater than the individual protection with either …
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
… regulator of coagulation and a cofactor of Activated Protein C (APC). TM and APC modulate the homeostasis of thrombosis, diminish the release of inflammatory mediators, and inhibit the immune cell infiltration into islet grafts. Moreover, CD47 binds to signal regulatory protein alpha …
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Inflammatory and coagulation disturbances in acute pancreatitis
… AP were investigated. Their plasma levels of protein C (PC) and activated protein C (APC), and monocyte HLA-DR expression were studied during the treatment period in the intensive care unit; 13 of these patients developed OF. In the second study, the serum levels of complement regulator …
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Einfluss des HMG-CoA-Reduktase-Inhibitors Simvastatin auf Überleben und hämodynamische Parameter im murinen Sepsismodell
… treating sepsis is still challenging. Recently, activated protein C and low-dose hydrocortisone demonstrated a reduction of mortality rate. However, the latter remains on a high level ranging between 30% and 50%. Clinical trials and studies in animal models demonstrated so-called pleiotropic …
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Discovery Of Inactive E* Conformations In Thrombin And Other Vitamin K- Dependent Clotting Proteases
… proteases, activity unfolds when a zymogen is activated by limited proteolysis and the associated conformational changes result in the formation of a proper active site and oxyanion hole, both of which are required for efficient hydrolysis of peptide bonds. The transition from zymogen to active …
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Contribution of different types of phospholipids in blood coagulation
In case of an injury platelets become activated and proper interaction of blood clotting proteins with membranes of activated platelets is essential for maintaining a balanced hemostasis. Hemophilia and thrombosis are the two extremes of an imbalanced hemostasis where patients with hemophilia …