Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"activated T cells"”.
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Gluconeogenic FBP1 plays a key metabolic role in activated T cells
… is active in liver, kidney and skeletal muscle cells. This study suggests that FBP1 plays a novel non-gluconeogenic role in T cells. Targeted metabolomics using [13C]-6-glucose revealed a labeling pattern of F6P in stimulated CD3+ T cells that could only have resulted from FBP1 enzymatic …
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Retroviral-mediated gene transfer of Il-1β?cDNA into human activated T cells
Autologous activated T cells (ATC) are being utilized in clinical trials as potential mediators of anti-tumor cytotoxicity in refractory cancer patients who suffer from hematologic malignancies or solid tumors. ATC are readily generated from peripheral blood and possess non-major histocompatibility …
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The involvement of IRAK-1 in the regulation of NFATc2 in T cells
… immune responses. NFATc2 (nuclear factor of activated T cells) was found to be associated with IRAK-1 in T cells in vitro and its activity was elevated in the absence of IRAK-1. In addition, IRAK-1-/- mice had increased naturally occurring regulatory T cells and inducible regulatory T cells …
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Mechanism of TCDD-Induced Immunotoxicity: The Role of Cell Activation in the Generation of Toxicity
… that TCDD exerted immunotoxic effects only on cells differentiating in response to antigenic challenge. To this date, no work has been done to characterize the long-term effects of TCDD on the activated cells. Additionally, no studies have been done to determine whether TCDD has any effect on …
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Elucidating the molecular mechanisms of p110δ activation in T cell antigen receptor signalling
Phosphoinositide 3-kinases (PI3Ks) are activated in immune cells downstream of the antigen recognition receptors, the signals from which are crucial for the development, differentiation and activation of lymphocytes. Engagement of the T cell antigen receptor (TCR) initiates a signalling cascade …
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Novel Imaging-Based Techniques Reveal A Role For Pd-1/Pd-L1 In Tumor Immune Surveillance In The Lung
… receptor Programmed Death 1 (PD-1) on T cells to its ligand PD-L1 has been implicated as a major contributor to tumor induced immune suppression. Clinical trials of PD-L1 blockade have proven effective in unleashing therapeutic anti-tumor immune responses in a subset of patients with …
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Tsyn-Seq: A T Cell Synapse-Based Antigen Identification Platform
… system, which includes antigen-presenting cells (APCs) with a Fas-inducible NF-κB reporter and T cells with a nuclear factor of activated T cells (NFAT) reporter. To functionally screen for target antigens from a cDNA library, productively interacting T cell–APC aggregates were detected by …
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Effect of blueberry polyphenols on osteoclast
… and differentiation. RAW 264.7 murine macrophage cells were cultured, differentiated into osteoclasts and treated with varying blueberry polyphenols doses. Levels of Tartrate Resistant Acid Phosphatases (TRAP), Nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), cyclooxygenase-2 (COX-2) …
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Transcriptional Regulation of the Inducible Costimulator (ICOS) in T Cells
… expression during early activation of CD4+ T cells by T cell receptor and CD28 co-engagement as well as during the differentiation of these cells into Th1 and Th2 lineages. In recently activated T cells, our data suggests that the Fyn-calcineurin-NFATc2 and MEK2-ERK1/2 signaling axes cooperate …
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Regulation of the Nuclear Factor of Activated T Cell (NFAT) Family of Transcription Factors in the Freeze Tolerant Wood Frog, Rana sylvatica
… converted to extracellular ice. As a result, cells experience extensive dehydration when water exits as well as anoxia due to interruption of blood flow. Adapting to such challenges requires metabolic rearrangement, partially mediated by transcription factor control over gene expression. Here, …
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The role of the adapter protein TSAd in T cell activation
Introduction: T cells are a part of the adaptive immune system, which is designed to attack pathogens in the body. T cells recognize antigen presented by HLA molecules on the surface of antigen presenting cells (APC) through their T cell receptor. Conjugation formation between T cells and APC turns …
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Molekularbiologische Untersuchung intrazellulärer Signalwege, die in T-Lymphozyten zur Aktivierung des Transkriptionsfaktors NF-ATc führen
… Transkriptionsfaktor NF-ATc (Nuclear Factor of Activated T cells) kontrolliert die Genexpression in T-Lymphozyten. In dieser Arbeit, in der Jurkat-T-Zellen und embryonale 293-Zellen als Modellsysteme verwendet wurden, konnte gezeigt werden, daß die N-terminale transaktivierende Domäne TAD-A von …
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Vaccination and immunological memory
… the mechanism is unclear. CD4+ T helper memory cells (Thmem) are pivotal in controlling humoral and cellular responses, therefore their longevity and response to vaccination are critical for maintenance of protective immunity. To probe the dynamics of the Thmem response to antigenic challenge, …
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
… models can be used as an alternative to primary cells to study cardiac hypertrophy. Additionally, we show that all three IP3R proteins were expressed throughout the cardiomyocyte sarcoplasmic reticulum in neonatal and adult rat ventricular cardiomyocytes and in the human heart tissue. …
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Structural and molecular studies of group II leukocyte immunoglobulin-like receptors.
… and are primarily expressed on myelomonocytic cells. Group I LILRs include the well-characterised members LILRB1 and LILRB2, which bind MHC Class I and transduce inhibitory signals. Group II LILRs, by comparison, are poorly understood. Particular interest has arisen in the Group II receptor, …
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CNS-Specific, Autoreactive CD8+ T Cells Have a Regulatory Role in Autoimmune Demyelination
… or by adoptive transfer of CNS-specific activated T cells. The vast majority of studies in MS and EAE have focused on the role of CD4+ T cells in this disease, with the underlying assumption that MS, like EAE, is a CD4+ Th1-mediated autoimmune disease. However, several reports have …
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Staphylococcal Enterotoxin B-Induced Acute Lung Injury:Mechanism and Treatment of Disease
… 60%, based on the age of patients. The role of activated T cells and failure in capillaries of the lungs has been demonstrated in ALI; however the detailed mechanism of disease remains unclear. This study offers a better understanding of the mechanism of Staphylococcal Enterotoxin B …
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Overcoming T Cell Tolerance Against Endogenous Choroid Plexus Tumors Using a Combination Immunotherapy
We target T cells escaping clonal deletion to study effects of a combination of immunotherapies against endogenously arising choroid plexus tumors. The model we use is the SV11 mouse transgenic for large T antigen of simian virus 40. Mice are immunologically tolerant to the choroid plexus tumor. We …
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T-cell-directed bioorthogonal catalysis for localised prodrug activation in cancer therapy
… catalysis in combination with engineered T-cells to locally activate anticancer drugs. Catalysis-augmented T-cell therapy is a newly developed platform technology, in which T-cells, engineered to express a surface protein upon cancer recognition, are used as an inducible antigen to recruit …
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T cell mediated satellite cell function: implications for age-associated changes in skeletal muscle regeneration
… Current research also suggests that T cells of the immune system may influence skeletal muscle repair via signaling with MPCs. The objective of the present study was to examine the influence of activated T cells on MPCs. MPCs were collected from the gastrocnemius and plantaris from …
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