Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 53 for “"actinomycin"”.
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The effects of actinomycin on deoxyribonucleic acid treated with methyl methanesulfonate
Call number: LD2668 .T4 1968 M3244
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The effects of actinomycin on deoxyribonucleic acid treated with methyl methanesulfonate
Call number: LD2668 .T4 1968 M3244
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The Effects of Actinomycin D and Acth on Circadian Steroidogenesis of Hamster Adrenals
Rhythmicity is predominant in nature. Sunrise is followed by sunset in a highly predictable periodic sequence. Living organisms are known to be influenced by such periodically occurring phenomena. De Mairan, as early as 1729, observed leaf movements of plants and found these variations to be …
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Biochemical Studies of the Purine Analogues, 2-Aminopurine and 2,6 Diaminopurine
… from that of dAT (ρ = 1.679). The antibiotic actinomycin has been shown to inhibit RNA polymerase by binding to helical DNA. The specificity of this interaction is thought to be determined by the 2-amino group of guanine since neither dAT nor dI:dC interact with the antibiotic. dAT-like …
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Nuclear and Plasma Membrane Properties of Macrophage Heterokaryons and Hybrids
… content of each nucleus. Studies with actinomycin showed that heterokaryon RNA synthesis was essential for subsequent macrophage DNA synthesis. This RNA was synthesized one - four hours before the DNA and was unlikely to be ribosomal RNA since it was insensitive to < 0.1 μg/ml …
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Some in vivo effects of triiodothyronine on purine nucleotide synthesis
… was observed in the GMP. Treatment of rats with actinomycin D prior to hormone injection did not prevent the stimulation of synthesis due to triiodothyronine. Actinomycin D alone stimulated the incorporation of the precursor into the soluble nucleotides and magnified the effects of the hormone in …
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Characterization of inducible antibiotic production by streptomycetes isolated from hyper-arid environments
… identify cinerubin B and unknown congeners of actinomycin (MW 1307.552). The latter were produced in large quantity by PH2 8 and further scale-up fermentation allowed the purification of an anti-E. faecalis metabolite.;Actinomycin Y1 was its main constituent however further purification is …
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Regulation and function of interphase histone H1 phosphorylation in pluripotent cell differentiation
… genes. Moreover, inhibiting transcription with actinomycin D induces the accumulation of pS187-H1.4 at promoters and gene bodies. Notably, the levels of pS187-H1.4 enrichment after actinomycin D treatment or cell differentiation reflect the extent of CDK9 recruitment at the same loci. …
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Apparent induction, kinetic and physical properties of the multiple species of ornithine decarboxylase, forms A and B, in the kidney and liver of hormone-treated rat
… stimulated rats were also given either LiC1, actinomycin D orputrescine, which decreased total ODC activity. The ODC A:B ratio was altered in some instances, but only within the kidney. In these cases, the enhanced proportion and most likely the stability of the B form of ODC was inhibited or …
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mRNA stability in soma and neurites of cultured neuronal cells
… cells following inhibition of transcription with actinomycin-D. Less stable transcripts were enriched for GU-rich elements in their 3' UTRs. Around 12% of alternative splicing isoform pairs differed in stability, and cassette alternative ("skipped") exons that negatively impact stability are …
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Utilization of Poly(A)-Binding Protein in Monitoring the Formation of mRNP Granules in Toxoplasma gondii
… localized in the cytoplasm under treatment with actinomycin D. Second, we also found that TgPABP aggregates into microscopically visible granules, as an indicative of mRNPs. Upon salubrinal treatment, mRNPs were formed in both extracellular and in intracellular parasites whereas cycloheximide can …
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Influence of Dietary Protein Intake on the Molecular Aspects of 7,12-Dimethylbenz(a)anthracene Induced Mammary Carcinogenesis (Cancer, Liver)
… following a 6-hour delay and was inhibited by actinomycin D. Rats were fed diets containing 7.5 or 15% protein supplied as casein. Restricting the protein intake of rats resulted in a decrease in metabolism and binding of DMBA to DNA in the isolated mammary cells after 6 hours of incubation. …
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Interrelationships among estrogen, insulin-like growth factor-I and cyclic adenosine monophosphate in the regulation of uterine progesterone and estrogen receptors
… inhibitors, or by pre-treatment of cells with actinomycin D or cycloheximide. These results suggest that regulation of PR occurs at the level of the PR gene, and that induction of PR stimulated by these agents requires activation of estrogen receptor (ER) and the action of protein kinases. …
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Translation and transcription are required for endogenous bursting after long term removal of neuromodulators
… (CHX) and the transcription inhibitor Actinomycin D (ACD). The results suggest that early transcription and late protein synthesis play an important role in the recovery process of the rhythmic activity in the pyloric network of the crab STG. Late protein synthesis probably involves ion …
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The effect of thyroid hormones an growth and metabolism of two species of teleost fish
… and RNA in liver and muscle of tilapia and carp. Actinomycin D inhibited this response to a certain extent. Thyroid hormones seem to be more important in the early than in later life of the tilapia as far as the growth is concerned. Temperature mediates the effects of T4 and T3 on cellular level …
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Development and characterization of cell-free amino acid incorporation systems from <u>Cellvibrio gilvus</u>
… but not effected significantly by DNAase and actinomycin D. The optimum pH and temperature for ¹⁴C-leucine incorporation were 7.8 and 300° C, respectively. Polyamiaes (putrescine, spermine, and spermidine) had a slight stimulatory effect on poly U-directed.¹⁴C-phenylalanine incorporation, but …
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Methods to Detect Apoptosis in Equine Peripheral Blood Neutrophils from Normal Healthy Adult Horses
… presence of four known inducers of apoptosis; actinomycin D, staurosporin, cycloheximide and sodium hypochlorite, at four different concentrations (table 2). A fifth population was to induce necrosis using a freeze-thaw cycle and bleach. A control sample was examined (no inducer) to determine …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… 40% in nandrolonetreated cells. Treatment with actinomycin D (10-5M), a transcription inhibitor, revealed that nandrolone may regulate MOPr mRNA stability. In SH-SY5Y cells transfected with a human MOPr luciferase promoter/reporter construct, nandrolone did not alter the rate of gene …
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