Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"actinomycetes"”.
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Laccases from actinomycetes for lignocellulose degradation
… of lignocellulose into simple sugars. Actinomycetes are known to produce laccases which are able to degrade lignin. Laccase activities were detected in actinomycete strains MS26 isolated from soil collected from the Zambian Copperbelt and DFNR17 isolated from soil collected from a New …
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Analysis and Engineering of Polyene Biosynthesis in Actinomycetes
The work in this thesis concerns the biosynthetic pathways to antibiotic natural products in actinomycete bacteria, and evaluates three different approaches to accessing novel chemical diversity from these pathways. In Chapter 1, major pathways of natural product biosynthesis in Streptomyces and …
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Isolation and characterisation of antibiotic-producing marine actinomycetes
… for the presence of antibiotic-producing actinomycetes. Of the 67 strains isolated, 26 exhibited antibacterial activity against Mycobacterium aurum A+ and for Enterococcus faecium VanA. These actinomycete strains were physiologically characterised. Three strains showing very strong …
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Mechanism of inhibition of fungi in agar in actinomycetes
Thesis (M.S.)--Michigan State University. Dept. of Botany and Plant Pathology, 1968
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The role of actinomycetes in the biodeterioration of wood
The role of actinomycetes in the biodeterioration of wood was reviewed and found to be unclear. Twenty Streptomyces isolates previously isolated from decayed wood were characterised according to the criteria of the International Streptomyces Project. Discrepancies between keys developed for …
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Studies on secondary metabolites produced by actinomycetes and cyanobacteria
Biosynthetic studies compounds showed that the Adda unit of nodularin was derived from C-2, C-3 and the phenyl ring of scL-phenylalanine as well as acetate and methionine. A separate feeding experiment with (2-$\sp{13}$C) pyruvate suggested that the methylaspartate (MeAsp) unit could be derived …
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Endophytic Actinomycetes as potential agents to control common scab of potatoes
<p>Potato marketability and tuber quality can be decreased upon infection by a pathogen, <em>Streptomyces scabies.</em> Current disease control consists of expensive irrigation systems and using hazardous chemicals, which exert limited disease control and are potential hazards to those exposed. …
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Investigations into actinomycetes isolated from coastal environments, with a special emphasis on the genus Micromonospora
Marine environments were investigated and actinomycetes were isolated on selective media. Thirty-four (34) actinomycete strains were isolated and identified: 21 Micromonospora strains, 10 Streptomyces strains, and 3 Pseudonocardia strains. A polyphasic approach was employed to determine the novelty …
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Investigating the chemical diversity and biomedicinal potential of South African actinomycetes for tuberculosis drug discovery
… biomedicinal potential of three South African actinomycetes, Streptomyces speibonae PK-BlueT , Streptomyces africanus CPJVR-H T and Streptomyces pharetrae CZA14T , was investigated. The primary aim was the isolation and structure elucidation of anti-tubercular natural products (NPs), including …
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Natural product discovery in actinomycetes and investigation into the regulation of SPI-1 in salmonella typhimurium
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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The characterisation of actinomycetes isolated from diverse South African sources, with emphasis on the genus Kribbella
Actinomycetes were isolated from the leaves of indigenous plants, aquatic sediment and soil samples, using alternative isolation methods to select for actinomycetes belonging to the rarer genera. Thirty actinomycete strains belonging to the genera Gordonia, Kineococcus, Kribbella, Micromonospora, …
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Exploring the molecular diversity and biomedicinal potential of marine invertebrates and South African actinomycetes for tuberculosis drug discovery
… (NPs). A range of marine invertebrates and SA actinomycetes were therefore studied for the discovery of new antimycobacterial NPs. Several organic and aqueous marine invertebrate extracts were screened for their in vitro inhibitory activity against the Mtb strain H37Rv. The chemical components …
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Actinomycete biodiversity assessed by culture-based and metagenomic investigations of three distinct samples in Cape Town, South Africa
… The results provided an explanation for why no actinomycetes were found in the aquatic samples, as all of the sequenced clones were shown to be most closely related to uncultured bacteria. In the terrestrial sample, a total of 120 clones were obtained and all were sent for sequencing.
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Synthesis of thiohistidines and its metabolic pathway precursors
… and ovothiols are biosynthesized by actinomycetes, fungi and many parasitic protozoa, respectively. Actinomycetes such as Mycobacterium tuberculosis produce mycothiol and ergothioneine as their principal low molecular mass thiols. It is only very recently that the link between …
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Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes
… The MshB reducing agent exclusively in the actinomycetes is used as a model for the development of new anti-TB drugs. It was shown that the stereoselectivity synthesis of C-2 alkyl glucoside gave a key intermediate for the suitable synthesis of glycosyl donors. In addition, we achieved the …
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Rationalising the inhibition of M. tuberculosis MshB by a series of inhibitors constructed from plumbagin conjugated via a viariable alkyl linker to a phenyl thioglycoside
… oxidative stress. Since mycothiol is unique to Actinomycetes and is also proposed to play an important role in the dormant state of Mycobacteria, the pseudo-dissacharide is seen as a potential target for novel anti-tuberculars. Targeting the mycothiol redox cycle has led to MshB inhibition by a …
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Gene cloning studies in two nocardioform bacteria
Nocardioforms are Gram-positive, aerobic actinomycetes and are a metabolically diverse group which produce antibiotics, useful enzymes, are important in the biotransformation of organic compounds and the decomposition of organic wastes and are important medically. A gene cloning vector designated …
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