Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"actin cytoskeleton reorganisation"”.
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The role of Rnd3 in kidney morphogenesis and function
… of the Rho family of GTPases and has a role in actin cytoskeleton reorganisation, cell cycle progression, and cell migration. The characterisation of the kidney phenotype revealed the onset of cyst formation in the cortex in 5-month-old adult Rnd3tm1b+/- kidneys. A significant upregulation in …
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Investigating the mechanisms and the temporal regulation of the first cell polarity establishment in the mouse embryo
… protein recruitment. Factors responsible for actin cytoskeleton reorganisation included Phospholipase C (PLC) – Protein Kinase C (PKC) pathway components, they directly activated actomyosin in the first phase through the Rho proteins such as RhoA. Further results showed that the apical protein …
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A mechanistic assessment of novel anticancer drugs targeting the metastatic cascade and tumour vascularisation.
… destabilisation. These include or are based on actin cytoskeleton reorganisation, cellular contractility and endothelial permeability. Eventually, the loss of the tightly-organised monolayer integrity of the endothelium results in blood vessel disruption and intratumoral haemorrhages. The …