Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"acquired epilepsy"”.
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… effects in several animal models of seizures and epilepsy, including the rat pilocarpine model of acquired epilepsy. However, the distribution of CBl receptor expression and function in brains of epileptic rats has not been characterized. Therefore, this dissertation was initiated to evaluate the …
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Epileptogenesis Causes Long-Term Plasticity Changes in Calbindin D-28k in the Rat Pilocarpine Model of Acquired Epilepsy
Epilepsy is one of the most common neurological disorders, affecting more than 2% of children and 1% of adults in the U.S. Emerging research has demonstrated that calcium, as a major second messenger system, underlies many of these injury-induced plasticity changes associated with the development …
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
Stroke is the most common cause of acquired epilepsy in persons 35 and older. The massive increase in extracellular glutamate during stroke causes a cascade of intracellular events that can lead to cell death or the molecular changes that initiate the development of epilepsy. In addition, many …
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
… and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis is the process wherein healthy brain tissue is transformed into hyperexcitable neuronal networks that produce AE. Understanding these alterations …
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Exploring the effects of classical immune activation on circuit excitability and cell viability in the mouse brain
Epilepsy directly affects approximately 50 million people globally and is the most common neurological disorder in sub-Saharan Africa, mainly due to high rates of neuroinfections and head trauma experienced by people in the region. A common factor in these causes of acquired epilepsy is their …
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ACQUIRED ALTERATIONS IN THALAMIC T-TYPE CALCIUM CHANNELS IN MODELS OF NEURONAL HYPEREXCITABILITY
… a chemically-induced model of temporal lobe epilepsy (TLE), and a model of chronic alcohol withdrawal following repeated intermittent exposures to ethanol. In particular, one T-type Ca2+ channel isoform, CaV3.2, was investigated for its role in producing a hyperexcitable population of neurons …
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Establishing in vitro models of neuroinflammation to investigate neuroimmune responses in neurocysticercosis
… Taenia solium, is the leading cause of adult-acquired epilepsy in the world. A surprising clinical manifestation of NCC is that viable larvae can exist in the brain for extended periods with no symptomatology, but when they die, clinical symptoms develop. Clinical evidence suggests that the …