Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"acinar morphogenesis"”.
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
… <p><em>disrupts normal mammary acinar morphogenesis and serves as the initial route into</em></p> <p><em>breast tumor development. </em>We first demonstrate that LMW-E overexpression in</p> <p>non-tumorigenic hMECs is sufficient to induce tumor formation in athymic mice</p> …
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Cooperative Genomic Events Driving Mutant TP53-Driven DCIS Progression
… <em>TP53</em> in human MCF-10A cells using acinar morphogenesis and migration assays. Overexpression of <em>TMEM267</em> in cells with mutant <em>TP53</em> caused a significant increase in the filled duct, DCIS-like phenotype. RNAscope revealed increased expression of <em>Tmem267 </em>in …
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The Role of Tumor Suppressor Dear1 In The Acquisition of Mammary Stem/Progenitor Cell Properties
… in DCIS lesions and IDC. DEAR1 regulates acinar morphogenesis and cell polarity and is a negative regulator of TGF-β-driven EMT through inhibition of SMAD3. Studies have now demonstrated that induction of EMT promotes acquisition of stem/progenitor cell properties, further adding to the …
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Gain-of-Function Effects of Mutant p53 Explored Using a Three-Dimensional Culture Model of Breast Cancer
… highly reminiscent for many aspects of acinar structures found in vivo. On the other hand, breast cancer cells, when placed in the same environment, form highly disorganized and sometimes invasive structures. Modulation of critical oncogenic signaling pathways has been shown to …