Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 18 of 18 for “"acinar cell"”.
-
The Role of Munc18 Proteins in Physiologic and Pathologic Exocytoses in the Pancreatic Acinar Cell
… fusion events in the polarized pancreatic acinar cell involve highly specific interactions between distinct sets of SNARE proteins forming exocytotic complexes, whose assembly is modulated by distinct Munc18 proteins. The Munc18 isoform responsible for these exocytotic events in the acinar …
-
Establishing The Role Of The Pancreatic Transcription Factor Mist1 In Xbp1-Mediated Maintenance Of Pancreatic Acinar Cell Homeostasis
<p>Pancreatic acinar cells (PACs) continuously produce more protein than any other cell type in the human body. As a result, PACs and other specialized secretory cells have a constant demand placed on their protein synthetic and packaging machinery. When demand for secreted products exceeds the …
-
LINEAGE TRACING ANALYSIS OF PANCREATIC ACINAR CELL DE DIFFERENTIATION AND TRANS-DIFFERENTIATION IN VITRO AND IN VIVO IN THE ABSENCE OF MIST 1
Previous studies suggest that mature pancreatic acinar cells can trans- differentiate into duct and islet cells in vitro; however, the intrinsic factors regulating this process have not been defined. The acinar specific transcription factor MIST1 is required for acinar cell maturation and targeted …
-
Investigating the role of the basic helix-loop-helix transcription factor MIST1 in pancreatic diseases
<p>Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute …
-
Manganese-stimulated protein phosphorylation in the rat pancreas.
… these studies suggest that in the pancreatic acinar cell Mn²⁺/CaM protein kinase activity is mediated via CaM PK III. Accordingly, CaM PK III was partially purified from the rat pancreas using Mn²⁺-stimulated phosphorylation of pure EF-2 to assay its activity. Gel filtration chromatography …
-
A Review of Perfluorooctanoic Acid Carcinogenicity and Application to Human Risk
… tumor triad consisting of liver adenomas, Leydig cell adenomas and pancreatic acinar cell tumors in male Spraque-Dawley rats. The ability of PFOA to produce tumors in rodents compounded by the fact that PFOA is accumulating not only in those occupationally exposed, but also in the general …
-
Altered Morphology And Composition Of Zymogen Granules In Acute Pancreatitis
… called Zymogen Granules (ZG), and activated extracellularly. In acute pancreatitis however, the digestive enzymes are prematurely activated within the cell, resulting in autodigestion of the tissue. Pancreatitis is a gastrointestinal disorder in which there are over 200,000 hospitalizations per …
-
Comparison of Ecto-Nucleotidase Activity in PAR-C5 Cells and Native Rat Parotid Gland
Cells from a parotid gland acinar cell line (PAR-C5) cells were investigated to compare the activity of the ecto-nucleotidase enzyme in those cells to those of native parotid gland acinar cells. The object of this study was to determine how useful the PAR-C5 cells are as a model for salivary gland …
-
Signaling and Adhesive Mechanisms in Acute Pancreatitis
… disease. It is widely held that premature intra-cellular trypsinogen activation and leukocyte recruitment play key roles in the pathophysiology of the AP. However, the signaling and adhesive mechanisms remain elusive. The aim of this thesis was to investigate the signaling and adhesive mechanisms …
-
Acute Pancreatitis. Studies on smoking and protease activation.
… These findings suggest that nicotine impairs acinar cell secretion. We propose that this might be a contributory mechanism behind the association between smoking and pancreatic disease.
-
The effect of ageing on the morphology and physiology of the lacrimal gland
… gland and in particular the lacrimal gland acinar cells. This study employed light and electron microscopy, immunohistochemical, radiobiological and physiological techniques to investigate ageing changes in the morphology and function of the lacrimal gland and acinar cells. In all …
-
Isoprenylation and NET formation in acute pancreatitis
… myeloperoxidase activity, chemokine levels, and acinar cell necrosis and edema formation in the pancreas. In paper I, farnesyltransferase mediates leukocyte sequestration and tissue injury in AP. Inhibition of farnesyltransferase attenuates infiltration of neutrophils in the pancreas and the lung …
-
The Secretory Pathway Calcium ATPase 2C promotes increased cytosolic calcium levels
Pancreatic acinar cell exocytosis requires precise calcium (Ca2+) signals. When cytosolic Ca2+ levels remain high, cellular functions are disrupted, which is associated with initiation of pancreatitis. Ca2+ signals are achieved through regulating endoplasmic reticulum (ER) stores, Ca2+ATPases, and …
-
Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
… is an irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with CP have a poor quality …
-
Tumour suppression mediated through DPC4, p53 and APC
… mediator, on murine primary cultured pancreatic acinar cells. Previously p53 ApcM "i+ mice have been shown to develop pancreatic tumours. To examine the effect of Smad4 heterozygous mutation on the development of these tumours, Smad4 +i mutation was introduced into p534- and p531- ApcM "v+ mice. …
-
The effects of ageing and streptozotocin (STZ) - induced diabetes mellitus on the rodent parotid gland
… with connective tissues, lipid droplets and mast cells compared to younger control glands. A significant (P<0.05) reduction in the mean acinar cell number was also observed in aged glands. Parotid glands taken from STZ-induced diabetic rats showed extensive infiltration of lipid droplets when …
-
Die neuronale Kontrolle der Speicheldrüse von Periplaneta americana
Die acinösen Speicheldrüsen der Schabe Periplaneta americana sind reich durch serotonerge, dopaminerge und GABAerge Fasern innerviert. Die biogenen Amine Serotonin (5-HT) und Dopamin (DA) induzieren die Sekretion eines NaCl-haltigen Primärspeichels. Die physiologische Rolle der GABAergen …