Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 119 for “"acidic pH"”.
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Single Liquid-Liquid Extraction of Delta-9-Tetrahydrocannabinol and 11-<i>Nor</i>-Carboxy-Delta-9-Tetrahydrocannabinol at an Acidic pH
… techniques for each. Because delta-9-THC is nonacidic, while delta-9-THCA is acidic, the extractions involve two separate pH levels, while GC/MS analysis requires two separate methods. This separation requires a great deal of time and materials. This experiment focused on eliminating the need …
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Effect of Tumor Microenvironmental Conditions on Non Small Cell Lung Cancer
… experience hypoxia, glucose deprivation and low pH even during the early stages of tumor growth. Tumor cells are proposed to adapt to these microenvironmental conditions by acquiring increased migratory and invasion potential and tumor initiating ability. Our research addresses the effect of …
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The Role of Urease in the Pathogenesis of Edwardsiella ictaluri
… experimental infection of channel catfish macrophages, the ureG mutant strain was attenuated for intracellular replication while the WT strain showed more than a ten-fold increase in numbers of viable organisms recovered at 12 hours post infection (PI), even though there were no significant …
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Evaluating the Co-commensal Lifestyles of Staphylococcus aureus and Staphylococcus epidermidis
Staphylococcus epidermidis is a ubiquitous skin commensal, and produces a serine protease Esp that can eradicate nasal carriage of the opportunistic pathogen, Staphylococcus aureus. We evaluated the ability of S. epidermidis and S. aureus to express serine protease and compete with one another in …
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An Interdisciplinary Investigation of Conformational Changes in Quasi-Crystalline Protein Array R-bodies in Response to pH
… change from a tightly coiled form at neutral pH to an extended helical spiral at acidic pH. R-bodies were found in bacterial endosymbionts of paramecia, where their forceful extension causes vacuolar membranes to rupture contributing to a type of inter-paramecium warfare (Pond et al., 1989). …
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Ammonia Volatilization and Urease Activity in Turf
… from turf whose underlying soil had an acidic pH. Eight different nitrogen fertilizers were evaluated for NH(,3)-N losses after application to turf. The rate and mode of urea application as well as the effects of thatch were also assessed for their effects on NH(,3) volatilization.
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Acidic Pericellular Ph: Effects On Proteolysis And Gene Expression As Determined In 3d Models Of Breast Carcinoma
… contribute to malignancy of solid tumors is an acidic peritumoral pH. The first objective was to determine if an acidic extracellular pH observed in vivo (i.e., pHe 6.8) affects the activity of proteases, such as cathepsin B, that contribute to degradation of collagen IV by tumor cells when …
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pH Stability of Calcium Hydroxide Preparations in a Simulated Acidic Environment
… medicament in endodontics, prized for its high pH, which provides antibacterial effects and promotes healing. However, its efficacy is challenged by the acidic pH of purulent exudates in infected root canals. This study aimed to evaluate the pH stability of three calcium hydroxide …
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Identification and characterization of low pH-triggered conformational changes in the herpes simplex virus glycoprotein B
Herpesviruses can enter host cells by pH-dependent endocytic pathways in a cell-specific manner. The role of pH in herpesvirus endocytosis is unclear. Herpes simplex virus (HSV) is a paradigm for virus membrane fusion via a complex of glycoproteins. HSV glycoproteins B, D and the heterodimer H-L …
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Histidine Folding Switch In Effector Protein Avrpto Regulates Its Transport Through The Bacterial Type Iii Secretion System, As Determined By Nmr, Fluorescence, Circular Dichroism Spectroscopies And Translocation Assays
… by histidine 87 that acts in the moderately acidic pH range expected in the biological environment of the bacterium. At neutral plant host cytosol of pH ~7.4 AvrPto is predominantly in the folded form. We disabled the His 87encoded pH switch by the H87Y mutation and observed a slight increase …
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Comparison of Extraction Techniques for Δ-9-Tetrahydrocannabinol from Urine
… the compound can be detected by chromatographic procedures. In past research, either a strong alkaline solution or β-glucuronidase has been used to cleave the bond between the Δ-9-THC and glucuronic acid before an alkaline extraction. Δ-9-THC has a pKa of 10.6 and therefore is always …
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Inhibition of TFEB activation promotes Coxiella burnetii growth
… replicative niche in the host cell. After being phagocytosed by the eukaryotic cell, the bacterium resides in a tight-fitting nascent phagosome which matures through the host canonical endocytic pathway, acquiring endosomal/lysosomal markers as well as acidic pH. Initial acidification of the …
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Chromium and uranium isotopic exchange kinetics and isotope fractionation during oxidation of tetravalent uranium by dissolved oxygen
… are two types of them. High concentration, acidic-pH experiments were conducted to determine equilibrium fractionations between hexavalent Cr (Cr(VI)) and trivalent Cr (Cr(III)), and between hexavalent U (U(VI)) and tetravalent U (U(IV)). Low concentration, neutral-pH experiments (closer to …
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Physikalische Hydrogele auf Polyurethan-Basis
Physical hydrogels have gained recent attention as cell substrates, since viscoelasticity or stress relaxation is a powerful parameter in mechanotransduction, which has long been neglected. We designed multi-functional polyurethanes to form physical hydrogels via a unique tunable gelation …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery
… multiblock copolymer (MBCP) with temperature/pH dual-sensitivity which undergoes gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal …
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Self-assembly and aggregation of glucagon-like peptide 1 and its analogues
Aggregation and physical instability of peptide-based drugs poses a great challenge to the pharmaceutical industry. Glucagon-like peptide 1 (GLP-1) is a hormone that is used in the treatment of type-2 diabetes. However, GLP-1 has a short half-life *in vivo* and it is prone to aggregate which …
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Turning stealth liposomes into cationic liposomes for anticancer drug delivery
… conjugate that removes the PEG coating at acidic pH as in the tumor interstitium. However, such a conjugate was highly unstable on shelf. Targeting the anticancer agents selectively to cancer cells is desirable to improve the efficacy and to reduce the side effects of anticancer therapy. …
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Characterization of lactic acid bacteria from Nono, a Nigerian naturally fermented milk product
… and functional properties including tolerance to acidic pH and bile salt, antimicrobial activity against indicators of food borne pathogens, and resistance to antimicrobials. The LAB were enumerated and isolated from Nono using MRS, M l7 and MRS + LCysteine agars. These media were selected to …
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Investigating Hfq-dependent Small Regulatory RNA, Bsr34, and Its Roles in Brucella abortus Physiology and Pathogenicity
… that Bsr34 expression is entirely Hfq-dependent. Phenotypic analysis of a Δbsr34 mutant revealed no defects in in vitro growth or general stress survival but showed significant attenuation in a murine infection model, indicating a specific role in virulence. While an initial chloramphenicol …
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