Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"acid-sensitive"”.
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Identification of novel proteins that regulate the amino acid-sensitive mTORC1 pathway
… becoming clear how nutrients, specifically amino acids, activate mTORC1. The presence of amino acids leads to the recruitment of mTORC1 from the cytosol to the surface of the lysosomal membrane, allowing it to be activated downstream of growth factors. This amino acid-induced translocation is …
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Development of P(TMC)-Based Polymers for Sustained Delivery of Acid-Sensitive Drugs
… or PLG. However, PLG breaks down to form highly acidic by-products, which react with the peptide and alter the drug’s chemistry. Depending on the peptide, this can lead to reduced effectiveness or inactivation. In this work, a P(TMC)-based polymer was synthesized and assessed as a delivery …
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Assessing the Role of Declining Calcium in Biological Recovery on Zooplankton in Historically Acidified Lakes
… industrial emissions caused the widespread acidification of thousands of lakes in North America and Europe. Acidification has led to unprecedented damage on zooplankton communities, with reductions in species richness, and in extreme cases, local extirpations. Although lake pH is recovering …
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The identification of novel cys-loop receptor genes in Dirofilaria immitis
… a monosodium L-glutamate (MSG) and L-glutamic acid sensitive homomeric channel, whereas the Dim-GLC-2/Dim-GLC-4 heteromeric channel shows reduced MSG current amplitude. The Dim-LGC-49 homomeric channel is responsive to cholinergic compounds. Homology modelling of homomeric channels highlights …
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Part 1: Lanthanum(III) Triflate-Catalyzed Cyclopropanation via Intramolecular Methylene Transfer. Part 2: Reaction Design with Aromatic Ions - Nucleophilic Acyl Substitution and Organophotoredox Catalysts
… strategy is used to rapidly convert carboxylic acids to their corresponding acid chlorides with dichlorocyclopropene reagents. The effect of cyclopropene substituents and amine base additives on the rate of conversion is examined. A mild amidation protocol employing acid chloride formation is …
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… is shown to associate with a wortmannin insensitive 76 kDa serine phosphoprotein (pp76) distinct from the p85 subunit of PI 3-kinase. pp76 is phosphorylated by an okadaic acid sensitive, PI 3-kinase associated serine kinase (PAS kinase) with biochemical properties that distinguish it from …
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Studies on intracellular calcium pools in a pancreatic cell line
… guanosine 5'-triphosphate (GTP) and arachidonic acid are known to mobilize intracellular Ca²⁺ independent of the action of IP₃ and probably play important roles in Ca²⁺ signalling. In pancreatic ductal cells the precise mechanisms of intracellular Ca²⁺ movement however are not well known. The …
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Trans-2-aminocyclohexanol as a pH-sensitive conformation switch in liposomes
<p>Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads specifically at the low-pH target sites, such as in solid tumors, tissues with inflammation, and ischemia sites. Also, it helps drug/gene to escape endosome trapping and followed lysosome …
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Synthesis of Phthalocyanines and Porphyrazines for Photodynamic Therapy and Bioalytical Purposes
… peripheral functionalities such as nitro, amine, acid, aminooxy, and azide, some of which can be used for conjugation or labeling reactions were synthesized in good yields. Statistical condensation method, and ring opening metathesis polymerization capture and release strategy were employed but a …
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Stereoselective synthesis of piperidines
… ii alkylidenated resin-bound esters i to give acid-labile resin-bound enol ethers iii. These were cleaved to give amino ketones iv. The switch in the nature of the resin from acid-stable to acid-labile is key to the purity of the amino ketones iv, as during cleavage only the acid-sensitive enol …
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Mitochondria and Fatty Acid Homeostasis in the Aging Nervous System
… energy requirements, yet mitochondrial fatty acid metabolism (β-oxidation) is important for the maintenance of metabolic reserve capacity and excess lipid management. In aging neurons, this is compromised as β-oxidation capacity declines. 2) Mitochondria are often considered the “seat of …
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Synthesis and applications of core functional hyperbranched polyglycerol
… of a gold nanoparticle, and the synthesis of an acid sensitive unimolecular micelle. In the first application, the alkyne core is converted to an amine which allows the polymer to act as a ligand on the gold surface. Despite the presence of the amine, the particle’s remain neutral (zeta potential …
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The Role of [beta]2-Syntrophin Phosphorylation in Secretory Granule Exocytosis
… underwent Ca2+-dependent and okadaic acid-sensitive dephosphorylation upon stimulation of insulin secretion. Stimulation-dependent dephosphorylation was confirmed by immunoprecipitation of 32P-labeled GFP-b2-syntrophin.Mass spectrometry of immunoprecipitated GFP-b2-syntrophin allowed …
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Status and remediation of mercury in fish and aquatic ecosystems
… as some areas are recovering from the effects of acidic deposition while the entire region is increasingly influenced by climate change. In order to better understand the drivers and trends of mercury dynamics in New York State, my research was conducted in three phases: 1) the impact of lime …
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Effects of Acid Deposition and Changing Climate on the Hydrochemistry and Critical Loads of Watersheds in the Adirondack Region of New York
<p>Despite decreases in acidic deposition since the 1970s, the recovery of surface waters from acidification has been limited primarily due to the depletion of exchangeable base cations, net mineralization of organic sulfur and nitrogen and release of previously retained SO42- and NO3-, and …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
… on two distinct ion channels: human TWIK-related acid-sensitive potassium (hTASK-3) channels and murine hyperpolarization-activated cyclic nucleotide-gated (mHCN) channels. hTASK-3 channels belong to the family of two pore domain potassium (K2P) channels, which are voltage- and time-independent …
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Novel expression and production of Foot-and-mouth disease virus vaccine candidates in Nicotiana benthamiana
… other members of the Picornaviridae family, is acid and heat-labile. The second aim of this study was to promote the stability, and hence encourage the amount of the VLPs produced, by engineering acid and heat-resistant mutants, namely, VP1 N17D, VP2 H93C and VP1 N17D/VP4 S73N using …
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Uptake, translocation, and metabolism 2,4-D in enlist crops and control of drought-stressed waterhemp (Amaranthus tuberculatus) with 2,4-D and glyphosate
… auxin herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), is one of the oldest and most widely-used herbicides in the world and is a systemic, postemergence (POST) herbicide that is selective in monocots such as corn, wheat, sorghum, and turf, but dicots are sensitive to 2,4-D. Auxin …
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Development of new GABA uptake inhibitors derived from proline or from pyrrolidin-2-yl acetic acid
… substitution of the nitrogen atoms in Nicopetic acid (11), Guvacine (12) and cis-4- Hydroxynicopetic acid (13) with appropriate bulky lipophilic groups resulted in very potent GABA uptake inhibitors for GAT-1 as well as for GAT-3. Pyrrolidine-2-acetic acid derivatives with the three …
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An exploratory study of Helicobacter suis control strategies
… group antigen-binding adhesin BabA, the sialic acid-binding adhesin SabA and the adherence-associated lipoproteins AlpA and AlpB. It was concluded that although genes coding for some important virulence factors in H. pylori, such as the cytotoxin-associated protein A (CagA) and the vacuolating …