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Showing 1 to 4 of 4 for “"acid ceramidase"”.
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Analysis of rat brain lipids and metabolites after antidepressant drug treatment
… of the brain sphingolipid pathway namely, acid sphingomyelinase (ASM) and acid ceramidase (AC). By using real-time quantitative polymerase chain reaction (RT-qPCR) it was shown that paroxetine and desipramine significantly reduced mRNA levels of ASM in the HP while effects in the PFC and ST …
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Role of Ceramide Accumulation in the Ventromedial Hypothalamus in Driving Systemic Metabolic Impairments During Obesity
… effects. To study this, we have overexpressed acid ceramidase in neurons in the ventromedial hypothalamus (VMH); this will decrease ceramide content specifically in this brain region vital to the control of glucose homeostasis and body weight. We found that ceramide accumulation in the VMH …
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Ceramide Accumulation in the Alpha Cell Drives Glucagon Secretion and Hyperglycemia
… from arachidonate -- an essential free fatty acid. Since this biosynthetic precursor has many roles in metabolic processes, researchers gained interest in the functions that lipids and their metabolites might play in other cellular processes (William W. Christie AOCS Lipid Library). In 1994 …
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Protein-sphingolipid interactions and their role in immunity and disease
… for further studies. The lysosomal enzyme acid ceramidase (AC) hydrolyses ceramide to sphingosine, thus regulating the levels of pro-apoptotic and pro-survival lipids. This role in apoptosis means that regulation of AC activity is of interest for cancer treatment. Although the structure of …