Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"acetyltransferases"”.
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Glucuronoxylan Acetylation Patterns and Site-specific Acetyltransferases
… Arabidopsis mutants for candidate xylan O-acetyltransferases were analysed, and four genes were found to be involved in xylan acetylation. TBL32 and TBL33 were shown to be responsible for the acetylation of xylosyl residues that carry a GlcA. Mutants in TBL3 and TBL28 also affected xylan …
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Reduction of the mycotoxin deoxynivalenol in barley ethanol co-products using trichothecene 3-O-acetyltransferases
… TRI101 and TRI201 are trichothecene 3-O-acetyltransferases that modify DON and reduce its toxicity. The first objective of this research was to isolate unique TRI101 and TRI201 enzymes that modify DON efficiently. We hypothesized that TRI101/TRI201 enzymes from different species of …
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Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
… of á-tubulin acetylation by investigating the acetyltransferases responsible. MEC-17 and ATAT-2 are á-tubulin acetyltransferases found in the TRNs, which illustrate mechanosensory defects when mutated. I found that mec-17 mutants exhibit a drastic decrease in TRN MT number as well as an …
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Targeting a Transcriptional Activator Induces Changes in Large-Scale Chromatin Structure and Nuclear Positioning
… and recruitment of three histone acetyltransferases. Based on the observed propagation of changes in large-scale chromatin structure, we suggest a possible rationale for the observed clustering of housekeeping genes within Mbp-sized chromosome sites.
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Regulation of Sister Chromatid by the Acetyltransferase Naa50
… and is mediated by a family of N-terminal acetyltransferases (NAT). Naa50 (also called San or NatE) has previously been shown to play a role in sister-chromatid cohesion in metazoans. The mechanism by which Naa50 contributes to cohesion is not understood, however. Here, I show that …
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Engineering diatom peptides for the synthesis of silica nanomaterials
… from which active methyltransferases, kinases, acetyltransferases, oxidases, and myristoyltransferases are identified from diatoms, humans, yeast, and bacteria. Modified R5 peptides are used for silica precipitation and the impacts on particle size, shape, porosity, and surface area are …
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Genetic polymorphisms and organophosphate neurotoxicity amongst emerging farmers in the Western Cape
… XMEs; glutathione S-transferases (GST), N-acetyltransferases (NAT) and Paraoxonase (PON1). RESULTS: Median age was 39 (30-48) and most had 9 years of education or less (65.5%). 54% of the participants were OP pesticide applicators. There was a low prevalence of the GST null genotype …
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Structural Analysis of Cycle Inhibiting Factor from Pathogenic Escherichia Coli
… triad, which includes cysteine proteases and acetyltransferases. Mutation of these conserved active site residues abolishes the ability of Cif to block cell cycle progression in different models. We demonstrate that Cif possesses auto-acetylation activity that is dependent on a wild-type …
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Lysine acetyltransferase Gcn5-B regulates the expression of crucial genes in Toxoplasma and its function is regulated through lysine acetylation
… in possessing two GCN5-family lysine acetyltransferases (KATs). While GCN5a is required for gene expression in response to alkaline stress, this KAT is dispensable for parasite proliferation in normal culture conditions. In contrast, GCN5b cannot be disrupted, suggesting it is …
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MOLECULAR STUDY OF CHROMATINOPATHIES: THE CASE OF RUBINSTEIN-TAYBI AND RETT SYNDROMES
… (RSTS) is characterized by CBP/p300 lysin-acetyltransferases deficit, while classic form of Rett syndrome (RTT) is caused by mutations in the reader MECP2. Both disorders show neurodevelopmental defects and 10 to 30% of patients remains without a molecular diagnosis. Methods: In this work, …
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Roles of Class II Histone Deacetylases in the Cardiovascular System
… by two opposing families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs), represents one of the fundamental mechanisms to control gene transcription. Class II histone deacetylases regulate developmental and physiological processes through interaction with and …
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Postnatal Role for Histone Deacetylase 1 and 2 in Behavioral and Neuronal Homeostasis
… without alterations in the DNA sequence. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) can influence gene activity by inducing either an active or inactive chromatin state, respectively. Accumulating in vitro data has demonstrated a crucial function for histone acetylation and …
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Histone Deacetylase 7 and Transcriptional Regulatory Networks of the Vascular Endothelium
… or inhibit gene transcription. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) are two such classes of enzymes that regulate the epigenetic code. Their opposing actions – to activate transcription by histone acetylation and to inhibit transcription by deacetylation – …
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Epigenetic Changes in Alzheimer’s and Huntington’sS Disease : A semi-quantitative analysis of histone changes
… the activity of histone deacetylases (HDAC) and acetyltransferases. Disruption in their activity can lead to malfunctioning cells, cell death and disease. There is increasing evidence suggesting that deregulation of histone acetylation and consequential effects leading to aberrant gene expression …
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Elucidation of the pathways responsible for the biosynthesis of UDP-N,N'-diacetylbacillosamine in bacterial pathogens
… explores the structural characterization of the acetyltransferases from the O-linked protein glycosylation pathways in N. gonorrhoeae (PglB-ATD) and A. baumannii (Weel). These enzymes are members of the left-handed [beta]-helix family and are responsible for the acetylation of …
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Effects of Quaternary Ammonium Disinfectants on Mouse Reproductive Function
… the exposed F0, with upregulation of two histone acetyltransferases (Hat1 and Kat2b) and downregulation of one lysine-specific demethylase (Kdm6b). F1 and F2 generations were not different from controls except for downregulation of the methyltransferase Dnmt1 in F1 progeny. The reproductive …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… transcription factors that interact with histone acetyltransferases and deacetylases. We show that histone deacetylase inhibitors efficiently block adipocyte differentiation in vitro. Furthermore, through a loss-of-function approach, we provide evidence that histone deacetylases 1 and 2 play …
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Proteome-Wide Prediction of Acetylation Substrates
… mechanism of substrate recognition by several acetyltransferases, but traditional experiments to determine intrinsic features of substrate and site specificity have proven challenging. In my thesis work, I hypothesize that the primary amino acid sequence surrounding an acetylated lysine plays a …
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Ctla-4 transcriptional activation: regulation of induced expression
… for CTLA-4 activation. We found the histone acetyltransferases p300 is responsible for histone 3 acetylation at the CTLA-4 promoter, and its activity is required for CTLA-4 transcription. We also discovered a previously undiscovered role for topoisomerase I in expression of a variety of …
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The Role of Class I Histone Deacetylases in Cardiovascular Development and Disease
… through the opposing actions of histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors continue to show promise in a multitude of pathological settings such as cancer and heart disease, however the role of individual HDACs remains largely unexplored. Genetic …
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