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Showing 1 to 20 of 151 for “"acetyltransferase"”.
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Choline Acetyltransferase and Carnitine Acetyltransferase Activity in Human Spermatozoa During Capacitation
<p>The regional distribution of ChAT activity in human spermatozoa is altered during in vitro capacitation and it correlates with the fertilizing potential of sperm.</p> <p>Regional immunoreactivity in human spermatozoa as assessed by fluorescent immunocytochemistry was compared with ChAT and CaAT …
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The Substrate and Regulator of Acetyltransferase San
… roles in numerous cellular events. San is an acetyltransferase required for proper chromosome segregation in Drosophila and human, but little is known about its substrates or upstream regulators. To identify San substrates, I performed affinity purification and demonstrated that tubulin is a …
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Regulation of Sister Chromatid by the Acetyltransferase Naa50
… and is mediated by a family of N-terminal acetyltransferases (NAT). Naa50 (also called San or NatE) has previously been shown to play a role in sister-chromatid cohesion in metazoans. The mechanism by which Naa50 contributes to cohesion is not understood, however. Here, I show that …
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Lateral Parabrachial Choline Acetyltransferase Neurons and the Decision to Eat
… the acetylcholine synthesis enzyme: choline acetyltransferase (ChAT). In this study, we used ChAT-CRE mice to investigate the anatomical projections, the calcium dynamics, and the causal role of the LPBN ChAT neurons. Anatomical projection results were produced using CRE dependent viral …
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Choline Acetyltransferase From Rat and Bovine Brain: Purification and Some Properties
Made available in DSpace on 2014-12-14T04:27:35Z (GMT). No. of bitstreams: 1 7709163.pdf: 5254710 bytes, checksum: e1793d90436613a8c58d1e80ce971af2 (MD5) Previous issue date: 1976
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Experimental and computational methods for identification of novel fungal histone acetyltransferase Rtt109 inhibitors
Rtt109 is a fungal-specific histone acetyltransferase that catalyzes histone H3 lysine 56 acetylation and is a promising antifungal drug target. To identify novel Rtt109 inhibitors as potential drug scaffolds, we employed in vitro high throughput screening (HTS) and various computer-assisted …
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Role of The Gcn5 Histone Acetyltransferase In Spinocerebellar Ataxia Type 7 and In Immature Neurons
… tract in ATXN7, a component of the SAGA histone acetyltransferase (HAT) complex. Previous studies provided conflicting evidence regarding the effects of polyQ-ATXN7 on the activity of Gcn5, the HAT catalytic subunit of SAGA. Here I showed that reducing Gcn5 expression accelerates both cerebellar …
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The effects of pulsed static and oscillating magnetic fields on rat pineal serotonin N-acetyltransferase activity
… more specifically the pineal enzyme, serotonin N-acetyltransferase (SNAT), inhibiting the enzyme and thus melatonin production. The enzyme assay required, for performing this type of work is crucial, as the natural decay of the enzyme could bias experimental results. An assay for measuring SNAT …
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Heterologous expression of alcohol acetyltransferase genes in Escherichia coli and Clostridium acetobutylicum for the production of esters
… on the heterologous expression of alcohol acetyltransferase (AATase) genes in Escherichia coli and Clostridium acetobutylicum for the production of the esters isoamyl acetate, butyl acetate and butyl butyrate. Isoamyl acetate, butyl acetate and butyl butyrate are esters that confer a fruity …
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Biochemical characterization of Cj 1123 c, a putative acetyltransferase & Cj 1319, a putative C6 dehydratase from Campylobacter jejuni.
… Two such proteins are Cjll23c, a putative acetyltransferase and Cj 1319, a putative GDP-mannose dehydratase encoded by the N- and O-linked protein glycosylation loci in C. jejuni, respectively. We show that Cjll23c is responsible for the synthesis of UDP- diacetamidobacillosamine. We also …
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Non-Enzymatic Activity Of The Alpha Tubulin Acetyltransferase Alpha-Tat1 Differentially Alters The Stability Of Dynamic And Stable Microtubules
… a mystery. We hypothesized that α-tubulin acetyltransferase (αTAT), which both stabilizes long lived microtubules against mechanical stress via acetylation and has been implicated in promoting microtubule dynamics, could play a role in this process. Biophysical reconstitution experiments …
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Novel functions of N-acetyltransferase 10 (NAT10) in DNA repair and replication with potential implications for premature ageing syndromes
… of a cure remains elusive. Inhibition of the acetyltransferase activity of the N-acetyltransferase 10 (NAT10) protein has been shown to have profoundly positive effects on both cellular and mouse models of premature ageing; however, the pathways it is involved in remained largely unexplored. …
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Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
… and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk
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Lysine acetyltransferase Gcn5-B regulates the expression of crucial genes in Toxoplasma and its function is regulated through lysine acetylation
… in possessing two GCN5-family lysine acetyltransferases (KATs). While GCN5a is required for gene expression in response to alkaline stress, this KAT is dispensable for parasite proliferation in normal culture conditions. In contrast, GCN5b cannot be disrupted, suggesting it is …
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Human Estrogen Receptor(alpha) Activity on Estrogen Responsive, Integrated Chloramphenicol Acetyltransferase (Cat) Reporter Constructs in Chinese Hamster Ovary (Cho) Cells
The estrogen receptors endogenous to CHO cells did not induce transcription of chromosomal copies of the more complex 2ERETKCAT promoter. In transient transfections hER$\alpha$ regulated transcription of the three 2ERETKCAT cell lines. We found that an ER mutant containing only AF1 elicited a dose …
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EXPRESSION OF HISTONE DEACETYLASE 4 AND HISTONE ACETYLTRANSFERASE 4 IN HUMAN MASSETER MUSCLE: RELATIONS TO FIBER-TYPE COMPOSITION IN PATIENTS WITH MALOCCLUSIONS
… histone deacetylase-4 (HDAC4) and histone acetyltransferase-4 (MYST4) and expression of myosin heavy chain (MyHC) genes and fiber-type percent occupancy (%Occ) in masseter muscle of patients undergoing orthognathic surgery to correct severe dentofacial malocclusions. The diagnostic …
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Characterization of the genetic variability of human arylalklamine-N-acetyltransferase (AA-NAT) and its potential effects on melatonin production and the sleep pattern
The human sleep/wake cycle is characterized by a circadian rhythm of circulating melatonin levels, which has been attributed to the cyclic expression of its biosynthetic rate-limiting enzyme, arylalkylamine-N-acetyl-transferase (AA-NAT). Genetic variability of the AA-NAT gene may therefore …
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Investigation of DNA methylation at the promoter region of the aralkylamine N-acetyltransferase (AANAT ) gene in South African children with Autism Spectrum Disorder
… Spectrum Disorder (ASD) traits. Aralkylamine N-acetyltransferase (AANAT) acts as the penultimate and rate-limiting enzyme in the melatonin biosynthetic pathway, and a study by Hu et al. (2009) reported that AANAT expression was suppressed in an ASD population with severe language impairments. …
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