Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"acetylcholinesterase inhibitors"”.
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Electrochemical multiphase microsensor for detection of acetylcholinesterase inhibitors
In the present work, we utilize a microscale gas-liquid interface for use in a selective gas microdetector for detection of toxic organophosphates (OP) compounds. Previous work in our lab has demonstrated that OP compounds can be selectively detected using such a sensor fabricated in polycarbonate; …
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Predictors of Response to Acetylcholinesterase Inhibitors: An Observational Case Register-Based Cohort Study
Background: Acetylcholinesterase inhibitors (AChEIs) are a key component of dementia care. Longitudinal cognitive change in patients before and after AChEI initiation has never been described previously, although individual responses have been described as heterogeneous. Predictors of such …
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Small Core Heterocyclic Carbamates and Carboxamides: Resistance-breaking Acetylcholinesterase Inhibitors Targeting the Malaria Mosquito, Anopheles gambiae
… and 3-oxoisoxazole- 2(3H)-carboxamide as acetylcholinesterase inhibitors (AChE) targeting wild type (G3) and resistant (Akron) malaria mosquito Anopheles gambiae (Ag). Isoxazole carboxamide and carbamates were obtained regioselectively through judicious use of two different protocols. The …
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Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae
… of species-selective aryl methylcarbamate acetylcholinesterase inhibitors to combat the malaria-transmitting mosquito, Anopheles gambiae. We identified six novel carbamates that demonstrated levels of target selectivity exceeding our project milestone of 100-fold. Among the C2-substituted …
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Microfluidic electrochemical sensors for the selective detection of toxic compounds
… utilizing an oxime reagent for the detection of acetylcholinesterase inhibitors. However, two other liquid chemistries based on the principles of chemical amplification were also studied in great detail. Research first focused on improving the life time of the oxime reagent in solution. The oxime …
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Length of Hospital Stay, Delirium and Discharge Status Outcomes Associated With Anticholinergic Drug Use in Elderly Hospitalized Dementia Patients
… are a significant proportion of patients taking acetylcholinesterase inhibitors (ChEi) for cognitive dysfunction also taking medications with anticholinergic (ACh) properties that may counteract their effects. As the number of ACh medications, burden, increases so does the likelihood of an …
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Characterising hippocampal replay in the APP<sup>NL-G-F</sup> mouse model of Alzheimer’s disease
… levels are reduced in Alzheimer’s disease and acetylcholinesterase inhibitors, which increase the availability of acetylcholine in the brain, form one of the few approved therapeutic treatments. However, acetylcholine has been hypothesised to modulate the balance between encoding and …
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Trifluoromethyl ketones: Potential insecticides towards Anopheles gambiae
… insecticides we have explored several classes of acetylcholinesterase inhibitors. In vitro assay studies have shown that trifluoromethyl ketones (TFK's) are potent inhibitors of An. gambiae AChE (AgAChE), that inhibit the enzyme by making a covalent adduct with the catalytic serine of the enzyme. …
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Validation of brief cognitive tests in mild cognitive impairment, Alzheimer's disease and dementia with Lewy bodies.
… was found useful for evaluating treatment with acetylcholinesterase inhibitors (AChEI) in patients with AD. II. Easy and quick interpretations of the MMSE, clock drawing and cube copying differentiated patients with DLB from patients with AD. III. AQT was twice as sensitive as the MMSE in …
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Mild and Convenient Methods to Prepare N-Alkyl Tacrines
… of neuropsychiatric and behavioral disturbances. Acetylcholinesterase inhibitors (AChEI) are the mainstay for the treatment of AD. Acetylcholinesterase (AChE) catalyzes the hydrolysis of acylcholinesters with a relative specificity for acetylcholine (ACh). Observation of a deficiency of …
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Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
… hypothesized that voluntary wheel running or an acetylcholinesterase inhibitor donepezil treatment, started before neuromuscular decline, would delay neuromuscular impairment in 5xFAD mice. Using 3-month-old 5xFAD and wild type (WT) littermates, we provided voluntary wheel access for 4 weeks and …
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Fluoromethyl ketone prodrugs: Potential new insecticides towards Anopheles gambiae
… insecticides we have explored several classes of acetylcholinesterase inhibitors. In vitro assay studies demonstrate that tri- and difluoromethyl ketones can potentially inhibit An. gambiae AChE (AgAChE). These compounds inhibit the enzyme by making a covalent adduct with the catalytic serine of …
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Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease
… approaches rely on the administration of acetylcholinesterase inhibitors (AChEIs), memantine and monoclonal antibodies. However, these drugs provide only symptomatic relief and do not prevent progressive neurodegeneration. Among the above-mentioned approved drugs, AChEIs are suggested to …
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Acetylcholine and posttraumatic stress disorder.
… system. Benefits from administering acetylcholinesterase inhibitors (AChEI) to people suffering these symptoms have been demonstrated. Donepezil hydrochloride, a reversible inhibitor of the enzyme acetylcholinesterase, is used in the treatment of conditions with difficulties in …
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Biologische Untersuchungen zu Inhibitoren der Acetylcholinesterase und Erzeugung von neuen Leitstrukturen mittels "Random Chemistry"
… Arbeit wurden verschiedene Inhibitoren der Acetylcholinesterase (AChE) untersucht, die als potentielle Substanzen zur Behandlung von Morbus Alzheimer eingesetzt werden können. Die Hemmwirkung der einzelnen Substanzen wurde mittels Ellman-Test überprüft. Gemeinsames Strukturmerkmal der …
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HD-tDCS over Frontal Cortex and Neuropsychological Functioning in Cognitively Impaired Older Adults
… used to manage cognitive symptoms include acetylcholinesterase inhibitors (AChEIs) and NMDA-receptor blockers, while selective serotonin reuptake inhibitors (SSRI) and serotonin-norepinephrine reuptake inhibitors (SNRI) are common first-line medications for NPS, though all demonstrate …
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Investigation of Monoaminergic Neurotransmitter Systems as a Method to Study Alzheimer's Disease-Related Neurodegeneration
… Current treatments for AD include reversible acetylcholinesterase inhibitors and N-methyl-D¬-aspartate (NMDA) receptor antagonists, however, these medications only provide mild symptomatic benefits in a subset of AD patients. A great deal of work aimed at understanding the ongoing pathological …