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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 107 for “"acetylcholinesterase"”.
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Purification and properties of mammalian brain acetylcholinesterase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Antibodies to acetylcholinesterase: their detection and clinical significance
… primarily autoantibodies, to the enzyme acetylcholinesterase. The working method employed a recombinant human acetylcholinesterase as the capture antigen, and was developed after investigating different antigens, solid phase materials, coating procedures and blocking techniques. The …
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Electrochemical multiphase microsensor for detection of acetylcholinesterase inhibitors
In the present work, we utilize a microscale gas-liquid interface for use in a selective gas microdetector for detection of toxic organophosphates (OP) compounds. Previous work in our lab has demonstrated that OP compounds can be selectively detected using such a sensor fabricated in polycarbonate; …
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
… protects against its deleterious effects while acetylcholinesterase (AChE) bound to Aβ peptide, increases aggregation and cytotoxicity of Aβ fibrils. Here, we set out to examine factors that regulate the interactions of Aβ with HN and AChE. We found that ATP, known to decrease misfolding of Aβ, …
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Experimental and Computational Investigation of Tacrine-Based Inhibitors of Acetylcholinesterase
Acetylcholinesterase (AChE) terminates cholinergic neurotransmission by catalyzing the hydrolysis of the neurotransmitter acetylcholine (ACh). Inhibition of AChE has proven an effective treatment for the memory loss exhibited by early stage Alzheimer's disease (AD) patients; four AChE inhibitors …
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Microemulsions containing centella asiatica extract as antioxidant and anti-acetylcholinesterase agent
… coconut oil (VCO) presenting antioxidant and acetylcholinesterase inhibition activity derived from natural products to enhanced memory of AD patients. In the present study, the ternary phase behaviour diagrams were constructed based on microemulsion (ME) containing CAHE with varying ratios of …
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House Fly Head (Musca Domestica L.) Acetylcholinesterase Activation by N-Butanol
Made available in DSpace on 2014-12-11T18:05:35Z (GMT). No. of bitstreams: 1 7105209.pdf: 1621162 bytes, checksum: d3b13c80b3d596de51ae4224eff964cb (MD5) Previous issue date: 1970
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Predictors of Response to Acetylcholinesterase Inhibitors: An Observational Case Register-Based Cohort Study
Background: Acetylcholinesterase inhibitors (AChEIs) are a key component of dementia care. Longitudinal cognitive change in patients before and after AChEI initiation has never been described previously, although individual responses have been described as heterogeneous. Predictors of such …
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Regeneration of ventral roots into the dorsal horn and axoplasmic flow of acetylcholinesterase
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Part One: Purification and Properties of House Fly Head (Musca Domestica L.) Acetylcholinesterase. Part Two: Inhibition of Fly Head Acetylcholinesterase by Bis(m-Hydroxyphenyl) Trimethyl Ammonium-Iodide Esters of Polymethylenedicarbamic Acid
Made available in DSpace on 2014-12-09T20:27:29Z (GMT). No. of bitstreams: 1 7020934.pdf: 2732339 bytes, checksum: d031d375b1327dd3442b7370d609366b (MD5) Previous issue date: 1970
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Biologische Untersuchungen zu Inhibitoren der Acetylcholinesterase und Erzeugung von neuen Leitstrukturen mittels "Random Chemistry"
… Arbeit wurden verschiedene Inhibitoren der Acetylcholinesterase (AChE) untersucht, die als potentielle Substanzen zur Behandlung von Morbus Alzheimer eingesetzt werden können. Die Hemmwirkung der einzelnen Substanzen wurde mittels Ellman-Test überprüft. Gemeinsames Strukturmerkmal der …
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Assessing the acetylcholinesterase inhibitory potential of novel pharmacophores for potential treatment of Alzheimer’s disease
… approaches rely on the administration of acetylcholinesterase inhibitors (AChEIs), memantine and monoclonal antibodies. However, these drugs provide only symptomatic relief and do not prevent progressive neurodegeneration. Among the above-mentioned approved drugs, AChEIs are suggested to …
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Purification, (0,0)-Dimethyl S-Aryl Phosphorothioates Inhibition, and Histochemical Localization of House Cricket Acetylcholinesterase
Made available in DSpace on 2014-12-11T18:05:41Z (GMT). No. of bitstreams: 1 7309979.pdf: 6052336 bytes, checksum: 47e82b1c2701ce25f3afc3b30d9112fb (MD5) Previous issue date: 1972
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Role of the Hu family of RNA-binding proteins in regulating acetylcholinesterase expression in excitatory cells
Post-transcriptional mechanisms regulating acetylcholinesterase (AChE) expression in muscle and neurons are relatively ill-defined, even though several studies have implicated mRNA stability as a means of controlling expression. We have, therefore, undertaken studies examining the role of …
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Small Core Heterocyclic Carbamates and Carboxamides: Resistance-breaking Acetylcholinesterase Inhibitors Targeting the Malaria Mosquito, Anopheles gambiae
… and 3-oxoisoxazole- 2(3H)-carboxamide as acetylcholinesterase inhibitors (AChE) targeting wild type (G3) and resistant (Akron) malaria mosquito Anopheles gambiae (Ag). Isoxazole carboxamide and carbamates were obtained regioselectively through judicious use of two different protocols. The …
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Revisiting aryl N-methylcarbamate acetylcholinesterase inhibitors as potential insecticides to combat the malaria-transmitting mosquito, Anopheles gambiae
… of species-selective aryl methylcarbamate acetylcholinesterase inhibitors to combat the malaria-transmitting mosquito, Anopheles gambiae. We identified six novel carbamates that demonstrated levels of target selectivity exceeding our project milestone of 100-fold. Among the C2-substituted …
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Exploring the interaction between asymmetric phosphonates and acetylcholinesterase. Probing the gorge and P-site via customized covalent modification
<P>Organophosphates (OPs) react with acetylcholinesterases (AChEs) to form a covalent bond at a specific serine residue in the active gorge, thereby providing a highly precise modification of this enzyme and an opportunity to explore protein structure, function and mechanism. The goal of this study …
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