Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"acetylcholine receptors"”.
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The Characterisation Of Bee Nicotinic Acetylcholine Receptors
… important insecticides are the nicotinic acetylcholine receptors. In this study we clone the majority of the Apis mellifera nAChR gene family and putative nAChR chaperones in an attempt to functionally characterise the pharmacological effects of these insecticides. Through the use of the …
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Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… that the two major CNS cholinergic nicotinic acetylcholine receptor subtypes a4p2 and a7 may interact directly with Ap and therefore, a multidisciplinary approach has been used to evaluate the reported interaction.
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Blockade of Acetylcholine Receptors by Cobra Toxin Electrophysiology and Pharmacology
… and irreversibly inactivates postsynaptic acetylcholine (ACh) receptors. Raja and Torpedo electroplaques also show nicotinic pharmacology and were similarly affected by the toxin. The toxin failed to affect the muscarinic receptors of the isolated frog heart or the receptors of Aplysia …
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The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
… regulate bone. Osteocytes express components for acetylcholine (ACh) receptors that are known for rapid firing at the neuromuscular junction. Although ACh is known to impact bone mass and fracture risk, the details regarding ACh signaling in bone mechanotransduction remain largely unexplored. This …
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Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes including learning, locomotion, pain, and reward behaviors. In this work we …
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Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
The α4β2 and α7 receptors are the most abundant nicotinic acetylcholine receptors (nAChRs) in the brain, where they contribute to cognition, reward, nociception and mood. They are also implicated in depression, schizophrenia, cognitive deficit and in addiction to nicotine (Nic). Activation of these …
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Evolutionary Analysis of Acetylcholine Receptors Type of Ligand-Gated Ion Channels
"In this thesis I have reconstructed the evolutionary history in animals where I focused on analyzing the complete genomes of seven widely different animals. My strategy of using complete genomes is based on ""absence of evidence is evidence of absence"". Of course there are gaps in the genetic …
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THE MECHANISMS AND PHARMACOLOGY OF NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS IN THE CENTRAL NERVOUS SYSTEM
Neuronal nicotinic acetylcholine receptors (nAChRs) are key players in both cognitive and autonomic processes. In the cognitive domains of the brain, destruction of cholinergic inputs or disruption of nAChR function result in cognitive deficits as observed in Alzheimer's disease, schizophrenia, …
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THREE-FINGER TOXINS AS SELECTIVE PROBES TO DISTINGUISH SUBUNIT INTERFACES OF NICOTINIC ACETYLCHOLINE RECEPTORS
… selectively antagonize postsynaptic nicotinic acetylcholine receptors (nAChRs). For the first time, the cryo-EM structure of a natural ?-neurotoxin, Erabutoxin-A (Ea), complexed with Tetronarce californica nAChR has been elucidated. From the atomic model, in silico Ea mutants at the nAChR …
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Heterologous Expression of Alpha 6*- Nicotinic Acetylcholine Receptors and the Natural Distribution of Alpha 6 Subunits
Nicotinic acetylcholine receptors (nAChR) are neurotransmitter-gated ion channels that exist as a family of subtypes defined by unique subunit compositions. nAChR containing α6 subunits (α6*-nAChR) have attracted interest because α6 subunits are thought to be localized in brain regions implicated …
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The role of high affinity nicotinic acetylcholine receptors on anxiety-like behavior: a study in female mice
… is known about the contributions of nicotinic acetylcholine receptors (nAChRs) on anxiety-like behavior. β2*nAChRs (*denotes assembly with other subunits) are the most abundantly expressed nAChRs in the brain yet little is known about the contributions of β2*nAChRs on anxiety-like behavior in …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site, allosteric modulators alter the response of the receptors to …
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Structural and molecular determinants of the sensitivity of alpha4beta2 nicotinic acetylcholine receptors to the allosteric ligand desformylflustrabromine
Allosteric modulation of neuronal nicotinic acetylcholine receptors (nAChRs) is considered to be one of the most promising approaches for therapeutics. By binding to a site of the receptor distinct from the neurotransmitter binding site allosteric modulators alter the response of the receptors to …
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The expression of muscarinc acetylcholine receptors on the avian vestibular hair cells and the modulation effects on KIR2.1
… vestibular efferent terminals onto hair cells is acetylcholine (ACh). Two types of acetylcholine receptors (AChRs) have been suggested to be located on hair cells (HCs). They were nicotinic receptors (nAChRs) and muscarinic receptors (mAChRs). Even though pioneering physiological and …
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Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas
… smoke, activates and/or desensitizes nicotinic acetylcholine receptors (nAChRs) throughout the brain. nAChRs in ventral tegmental area (VTA) dopamine (DA) neurons are crucial for the rewarding and reinforcing properties of nicotine. Nicotine causes cellular changes in VTA DA neurons, including …
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The emerging role of the a4(+)a4(-) interface as a determinant of functional signatures of a4ß2 nicotinic acetylcholine receptors
The a4~2 nicotinic acetylcholine receptor (nAChR) assembles in two alternate forms, (a4p2ha4 and (a4~2hP2, which display stoichiometry-specific agonist sensitivity. Being heteromeric pentameric ligand-gated ion channels (pLGIC), a4p2 receptors are activated by binding of agonist to sites located at …
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Classification of Neuronal Nicotinic Acetylcholine Receptors in Rat CA1 Hippocampal Interneuron Subpopulations Defined by Calcium-Binding Protein mRNA Expression
… calretinin, parvalbumin) and eight nicotinic acetylcholine receptor (nAChR) subunits (alpha2-alpha5, alpha7, beta2-beta4) from interneurons from the stratum radiatum or stratum oriens within the CA1 region of rat hippocampi was analyzed using quantitative real time RT-PCR. Eighty-seven percent …
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