Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 280 for “"acetylcholine"”.
-
Acetylcholine and posttraumatic stress disorder.
… been associated with dysfunctions in the central acetylcholinergic system. Benefits from administering acetylcholinesterase inhibitors (AChEI) to people suffering these symptoms have been demonstrated. Donepezil hydrochloride, a reversible inhibitor of the enzyme acetylcholinesterase, is used in …
-
The Characterisation Of Bee Nicotinic Acetylcholine Receptors
… important insecticides are the nicotinic acetylcholine receptors. In this study we clone the majority of the Apis mellifera nAChR gene family and putative nAChR chaperones in an attempt to functionally characterise the pharmacological effects of these insecticides. Through the use of the …
-
Non-Photic Phase Shifting: Acetylcholine and Arousal
… non-photic phase shifting. Neurotransmission of acetylcholine (ACh) is involved in bringing about arousal and also has been shown to play a role in the circadian system. The purpose of these experiments was to determine if ACh plays a role in non-photic phase shifting and to what extent arousal …
-
Nicotinic acetylcholine receptors and their interaction with Aβ₁₋₄₂
… that the two major CNS cholinergic nicotinic acetylcholine receptor subtypes a4p2 and a7 may interact directly with Ap and therefore, a multidisciplinary approach has been used to evaluate the reported interaction.
-
Acetylcholine dynamics in the retrosplenial cortex during spatial uncertainty
… uncertainty. Computational theories propose that acetylcholine (ACh) signals expected uncertainty, while noradrenaline signals unexpected uncertainty, but recent work suggests ACh may encode both prediction error and expected variance. How ACh contributes to uncertainty signalling in the …
-
Structure and Function of the Alpha3Beta4 Nicotinic Acetylcholine Receptor
Nicotinic acetylcholine receptors are pentameric ligand-gated ion channels that are essential for the proper function of the central and peripheral nervous systems. The α3β4 subtype is highly expressed in the autonomic ganglia, where it contributes to signal transduction from the central nervous …
-
Acetylcholine Regulation of the Hippocampus and Striatum During Learning
… just prior to learning. In Chapters 3 and 4, acetylcholine release was measured in the hippocampus and striatum just prior to and during learning. The results, in general, support the hypothesis that increases in cholinergic activity in the hippocampus and striatum facilitate acquisition of …
-
Interactions of acetylcholine and phospholipid metabolism in rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1994.
-
BETA 2 NICOTINIC ACETYLCHOLINE RECEPTOR CONTRIBUTIONS TO ANXIETY-LIKE BEHAVIOR
… to promote smoking behavior via nicotinic acetylcholine receptors (nAChRs) in the brain. Given reports that people smoke to relieve anxiety and that anxiety precipitates relapse, the overarching goal of this dissertation research is to assess beta 2 subunit containing nAChR (beta2*nAChR) …
-
Blockade of Acetylcholine Receptors by Cobra Toxin Electrophysiology and Pharmacology
… and irreversibly inactivates postsynaptic acetylcholine (ACh) receptors. Raja and Torpedo electroplaques also show nicotinic pharmacology and were similarly affected by the toxin. The toxin failed to affect the muscarinic receptors of the isolated frog heart or the receptors of Aplysia …
-
The Impact of Acetylcholine Receptors on Osteocytes and Bone Mechanoadaptation
… regulate bone. Osteocytes express components for acetylcholine (ACh) receptors that are known for rapid firing at the neuromuscular junction. Although ACh is known to impact bone mass and fracture risk, the details regarding ACh signaling in bone mechanotransduction remain largely unexplored. This …
-
Role of Muscarinic Acetylcholine Receptors in Adult Neurogenesis and Cholinergic Seizures
Muscarinic acetylcholine receptors (mAChRs) are G protein-coupled receptors (GPCRs) that mediate important functions in the periphery and in the central nervous systems. In the brain these receptors modulate many processes including learning, locomotion, pain, and reward behaviors. In this work we …
-
Searching for structural determinants of agonist selectivity in nicotinic acetylcholine receptors
… and α7 receptors are the most abundant nicotinic acetylcholine receptors (nAChRs) in the brain, where they contribute to cognition, reward, nociception and mood. They are also implicated in depression, schizophrenia, cognitive deficit and in addiction to nicotine (Nic). Activation of these …
-
Forebrain Acetylcholine in Action: Dynamic Activities and Modulation on Target Areas
… approaches.</p><p> First, to study fast acetylcholine (ACh) dynamics and its interaction with field potential theta oscillations, I developed a novel technique to acquire second-by-second electrophysiological and neurochemical information simultaneously with amperometry. Using this …
-
Evolutionary Analysis of Acetylcholine Receptors Type of Ligand-Gated Ion Channels
"In this thesis I have reconstructed the evolutionary history in animals where I focused on analyzing the complete genomes of seven widely different animals. My strategy of using complete genomes is based on ""absence of evidence is evidence of absence"". Of course there are gaps in the genetic …
-
A Molecular Mechanism for Endocytic Recycling of the M5 Muscarinic Acetylcholine Receptor
<p>Muscarinic acetylcholine receptors (MRs), a family of five G protein-coupled receptors (GPCRs), play an essential role in the regulation of mammalian physiology. In the brain, MR-mediated neurotransmission is required for the control of movement and motivated behavior by the basal ganglia, and …
Page 1 of 14