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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 336 for “"acetylation"”.
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The Acetylation of 1,1'-Dimethylferrocene
Made available in DSpace on 2014-12-05T19:36:55Z (GMT). No. of bitstreams: 1 5805465.pdf: 6028470 bytes, checksum: 6a94a5426ba017199de5e65c26291a3e (MD5) Previous issue date: 1958
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Proteome-Wide Prediction of Acetylation Substrates
… or by recruiting effector proteins to chromatin. Acetylation is one of the well-studied post-translational modifications that has been associated with chromatin-associated processes, notably gene regulation. Many studies have contributed to our knowledge of the enzymology underlying acetylation, …
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Acetylation regulates Thioredoxin Reductase activity and oligomerization
… were multiple experimentally identified TrxR acetylation sites with an unknown effect on TrxR activity. My thesis tested the hypothesis that programmed protein acetylation will enhance the activity of TrxR1. I used genetic code expansion (GCE) to produce Sec-containing and site-specifically …
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Metabolic Regulation of Protein Phosphorylation and Acetylation
Pages i-xviii are misnumbered in a variety of ways.
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H4K16 acetylation during embryonic stem cell differentiation
… DNA and can be modified by a variety of enzymes. Acetylation of Histone 4 Lysine 16 (H4K16ac) is an important modification associated with an increase in transcription, and in flies is an important component of the doseage compensation system. It is also unique amongst histone modifications in …
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Glucuronoxylan Acetylation Patterns and Site-specific Acetyltransferases
… the origin of the GlcA patterning, and the xylan acetylation processes are not fully understood. The xylan backbone is synthesised by two partially redundant Xylan Synthase protein Complexes (XSC). Removing subunits of one XSC causes a reduction in xylan length, and affects the GlcA pattern. Xylan …
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Can changes in SR protein acetylation affect alternative splicing?
… modification of SR proteins known as acetylation has recently been identified. The acetylation of lysine residues on proteins can result in changes in localization, function, and/or structure of modified proteins. The location and function of this post-translational modification on SR …
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EXPLORING THE MECHANISM OF ALGINATE ACETYLATION IN PSEUDOMONAS AERUGINOSA
… cystic fibrosis lung. Evidence suggests that the acetylation state of the mannuronate component of the alginate influences the ability of components of the immune system to phagocytose the organism. To garner new and relevant information regarding the mechanism of alginate acetylation in …
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The search for small molecule inhibitors of histone acetylation
Histone acetylation is a key mechanism of transcriptional regulation, which is mediated by two sets<br/>of enzymes; HATs and HDACs. Under normal physiological circumstances there is an orchestrated<br/>balance between the actions of HATs and HDACs. Disruption of this balance can lead to a …
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Intramolecular catalysis in the acetylation of 7a-hydroxy-5b-steroids
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
… sensitization to TKI was associated with EGFR acetylation. What we know so far is that SAHA can inhibit class I and II histone deacetylases (HDACs), which could possibly preserve acetylation of underlying HDAC-targeted proteins including both histone and non-histone proteins. In addition, it …
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… modifications, such as methylation or acetylation, on the H3 tail. Both <em>in vitro </em>and cell-based assays reveal that p300 ZZ domain, together with bromodomain (BRD), is important in recruiting p300 to chromatin. As a module adjacent to the histone acetyltransferase (HAT) domain, …
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The effects of histone acetylation on the maize allele PL1-blotched
… and condensed chromatin structure. To ask if acetylation of nucleosomal histone proteins might be involved in regulating the chromatin organization of Pl1-Blotched, this allele was crossed into 40 lines containing transgenes that target reduction of various histone acetyltransferase and …
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Microtubules, Acetylation, and MEC-3 Regulated Genes in C. Elegans Mechanosensations
… model for the study of neuronal MTs and MT acetylation, which is a poorly understood but widespread MT modification particularly in post-mitotic neurons. I employed TRN-specific RNAi to identify MT-associated proteins not previously known to be involved with mechanosensation including the …
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Regulation and Function of Zeb1 Acetylation In Lung Adenocarcinoma Progression and Metastasis
… resulted in the identification of a novel K811 acetylation site. To define the role of ZEB1 acetylation in regulating function, we generated ZEB1 acetyl-mimetic (K811Q) and acetyl-deficient (K811R) mutant-expressing non-small cell lung cancer cell lines (NSCLC). I demonstrated that the K811R …
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Characterisation of an acetylation-dependent FLIP/Ku70 complex that regulates FLIP expression
… ubiquitination.<br/><br/> Ku70 is a target for acetylation, and this acetylation is increased following treatment with HDAC inhibitors. The interaction between c-FLIP and Ku70 was demonstrated to be highly dependent on acetylation of Ku70, with acetylation of lysines K539 and K542 of Ku70 …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… the contribution of chromatin modification by acetylation of histone proteins. Mutating the histone acetyltransferase CREB-binding protein (CBP) impairs long-term memory formation, and pharmacologically blocking histone deacetylases (HDAC) enhances long-term memory formation. Memory enhancement …
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Effect of degree of acetylation on mechanical properties of cellulose acetate films
… These fractions had different degrees of acetylation but approximately the same degrees of polymerization. These fractions were then dissolved in acetone and cast into films which were conditioned for three days and their mechanical properties were determined in an attempt to determine the …
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The Effect of Estrogen on Synthesis and Acetylation of Histones in Rat Uteri
Made available in DSpace on 2014-12-11T22:22:11Z (GMT). No. of bitstreams: 1 7121071.pdf: 2592441 bytes, checksum: 64454ceae6697adf6208c2b0f0e35d39 (MD5) Previous issue date: 1971
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