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Showing 1 to 20 of 48 for “"acetyl-CoA carboxylase"”.
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Studies of Escherichia coli Acetyl-CoA carboxylase
Acetyl-CoA carboxylase (ACC) initiates the first committed step of fatty acid synthesis. ACC is composed of three separate components: biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP). BC carries out the first half of the ACC reaction where it catalyzes …
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Studies of Acetyl-Coa Carboxylase From Escherichia Coli
Preliminary functional assignments for the two subunits in the carboxyltransferase complex have been given. The alpha subunit (AccA) appears to have a structural role in the total ACC complex while the beta subunit (AccD) could contain the carboxyltransferase active site. The above conclusions are …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… this dissertation describes the requirement of acetyl-CoA carboxylase 1 (ACC1), the rate-limiting step of de novo fatty acid synthesis, for the development and progression of prostate cancer. Prostate specific deletion of ACC1 activity reduced tumor burden in 12-week-old C57BL/6J mice. However, …
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Characterization and analysis of genes encoding Escherichia coli acetyl-CoA carboxylase
Acetyl-CoA carboxylase catalyzes the first committed step of fatty acid biosynthesis, the synthesis of malonyl-CoA. In Escherichia coli the enzyme is a complex of four subunits that catalyzes two distinct half-reactions.
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… and function of invadopodia. Inhibition of acetyl-CoA carboxylase (ACC), the rate-limiting step of fatty acid synthesis, reduced invadopodia incidence in Src-transformed 3T3 (3T3-Src) cells. Blocking ACC or fatty acid synthase (FASN) activity also altered pathway activity and cellular …
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Functional and expression analysis of heteromeric acetyl-CoA carboxylase subunit genes of Arabidopsis
<p>Plant heteromeric acetyl-CoA carboxylase (htACCase) catalyzes the first and committed reaction of de novo fatty acid biosynthesis in plastids. Arabidopsis htACCase consists of five subunits: BCCP-1, BCCP-2, BC, alpha-CT, and beta-CT. They were encoded by CAC1-A, CAC1-B, CAC2, CAC3, and accD …
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Phosphorylation of Skeletal Muscle Acetyl-CoA Carboxylase by AMPK Enhances Palmitoyl-CoA Inhibition
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malnoyl-CoA, which in turn controls the rate of fatty acid metabolism. ACC beta or 2 has been shown to be localized on the mitochondria in close proximity to carnintine palmitoyl transferase 1 (CPT-1), the enzyme responsible for the influx of …
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Studies on the Regulation of Acetyl-CoA Carboxylase and its Influence on Bacillus subtilis Differentiation
… encoding two subunits of the essential enzyme acetyl-CoA carboxylase (ACC) is a direct target of the master regulator of sporulation, Spo0A. Binding of Spo0A to a cis-element (0A box) in the promoter region of the operon has recently been identified as a strict requirement for biofilm formation …
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… 1 (CPT1). CPT1 is potently inhibited by malonyl-CoA, the product of the acetylCoA carboxylation reaction that is catalyzed by acetyl-CoA carboxylase (ACC). Recent studies have demonstrated that metabolic fuels such as fatty acids and glucose can function as signaling ligands, directing …
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
… A novel target for antibacterial development is acetyl-CoA carboxylase, a multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The bacterial form of the enzyme consists of three proteins: biotin carboxylase, biotin carboxyl carrier protein, and …
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Effects of Temperature and Thyroid Hormone on Oxidative and Lipid Metabolism in Juvenile Lake Whitefish (Coregonus Clupeaformis)
… cytochrome c oxidase subunit 1), lipogenesis (acetyl-coA carboxylase , acetyl-coA carboxylase ) and peroxisomal -oxidation (acyl-coA oxidase 3) following exposure to elevated temperatures. However, the absence of effects on mitochondrial -oxidation enzyme isoforms, carnitine …
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The role of cysteine 230 and lysine 238 of biotin carboxylase in the deprotonation of biotin and synthesis of bisubstrate analogy inhibitor of carboxyltransferase
Acetyl-CoA carboxylase catalyzes the first step in the synthesis of fatty acids. The Escherichia coli form of the enzyme consists of a biotin carboxylase protein, a biotin carboxyl carrier protein, and a carboxyltransferase protein. This enzyme uses the cofactor biotin as a carboxyl carrier. In …
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Aspects of hormonal regulation of hepatic carbohydrate and lipid metabolism
… of glucokinase,<br/>ATP-citrate lyase and total acetyl CoA carboxylase. None of these<br/>enzyme activities increased when hepatic fatty acid synthesis was stimulated<br/>by feeding in control rats or by feeding and insulin in diabetic<br/>rats. Feeding stimulated active acetyl CoA carboxylase in …
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Phyisiological, genomic and metabolic characterization of the oleaginous yeast Papiliotrema laurentii UFV-1
… degradation, which may be alternative sources of acetyl-CoA for lipids accumulation. Analysis of expression and metabolic metabolism, including the NADP+-dependent malic enzyme, are the main sources of reducing the power for high accumulation of neutral lipids. Acetyl-CoA carboxylase activity is …
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A four-cysteine zinc finger in carboxyltransferase structurally links the functions of enzymatic activity and negative feedback regulation of translation
Acetyl-CoA carboxylase is the first and committed step of de novo fatty acid synthesis in all organisms. In Escherichia coli, the enzyme is expressed as separate proteins for the three functional components: a biotin carboxylase, a biotin carboxyl carrier protein, and a carboxyltransferase. The …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… troponin T expression and Akt, AMPK and Acetyl-CoA Carboxylase (ACC) phosphorylation state. Acute IL-15 treatment increased glucose uptake without activating insulin signaling pathway or GLUT4 translocation. Furthermore, acute IL-15 treatment increased resting oxygen consumption rate …
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Investigations on the mechanism of action of the oxime ether safeners for the protection of grain sorghum against metolachlor
… sorghum roots. Results from studies with acetyl-CoA carboxylase indicate that this enzyme is not a target site for either metolachlor or the oxime ether safeners. Metolachlor and the oxime ether safeners enhanced glutathione levels in grain sorghum seedlings at 12 to 48 hr after imbibition …
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NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC). Inhibition of the NAD<super>+</super>-dependent sirtuin deacetylases by Sirtinol treatment, or SIRT1/SIRT3 knockdown, phenocopied the effects of Nampt blockade on fatty acid synthesis thereby suggesting that Nampt …
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