Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"acetyl-CoA"”.
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Studies of Escherichia coli Acetyl-CoA carboxylase
Acetyl-CoA carboxylase (ACC) initiates the first committed step of fatty acid synthesis. ACC is composed of three separate components: biotin carboxylase (BC), carboxyltransferase (CT), and biotin carboxyl carrier protein (BCCP). BC carries out the first half of the ACC reaction where it catalyzes …
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Acetyl-CoA metabolism and human trophoblast differentiation
… enzyme that links glucose metabolism to histone acetylation by producing acetyl-CoA, a substrate for epigenetic modifications. The hypothesis was that ACLY is essential for maintaining trophoblast stemness by providing a localised supply of acetyl-CoA for histone acetylation, thus leading to a …
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Studies of Acetyl-Coa Carboxylase From Escherichia Coli
Preliminary functional assignments for the two subunits in the carboxyltransferase complex have been given. The alpha subunit (AccA) appears to have a structural role in the total ACC complex while the beta subunit (AccD) could contain the carboxyltransferase active site. The above conclusions are …
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ACETYL COA CARBOXYLASE 1 IN PROSTATE CANCER AS A CHEMOTHERAPEUTIC TARGET
… this dissertation describes the requirement of acetyl-CoA carboxylase 1 (ACC1), the rate-limiting step of de novo fatty acid synthesis, for the development and progression of prostate cancer. Prostate specific deletion of ACC1 activity reduced tumor burden in 12-week-old C57BL/6J mice. However, …
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Characterization and analysis of genes encoding Escherichia coli acetyl-CoA carboxylase
Acetyl-CoA carboxylase catalyzes the first committed step of fatty acid biosynthesis, the synthesis of malonyl-CoA. In Escherichia coli the enzyme is a complex of four subunits that catalyzes two distinct half-reactions.
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Investigation of molecular regulatory control of the cardiac-enrich acetyl-CoA carboxlase
… The current study was centred on the enzyme acetyl-CoA carboxylase (ACC) which catalyses the carboxylation of acetylCoA to generate malonyl-CoA, a central metabolite in the regulation of fatty acid oxidation (FAO). There are two isoforms of ACC, ACCa. and ACCj3, both of which are present in …
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Novel Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase and Lipogenesis
… and function of invadopodia. Inhibition of acetyl-CoA carboxylase (ACC), the rate-limiting step of fatty acid synthesis, reduced invadopodia incidence in Src-transformed 3T3 (3T3-Src) cells. Blocking ACC or fatty acid synthase (FASN) activity also altered pathway activity and cellular …
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Functional and expression analysis of heteromeric acetyl-CoA carboxylase subunit genes of Arabidopsis
<p>Plant heteromeric acetyl-CoA carboxylase (htACCase) catalyzes the first and committed reaction of de novo fatty acid biosynthesis in plastids. Arabidopsis htACCase consists of five subunits: BCCP-1, BCCP-2, BC, alpha-CT, and beta-CT. They were encoded by CAC1-A, CAC1-B, CAC2, CAC3, and accD …
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Phosphorylation of Skeletal Muscle Acetyl-CoA Carboxylase by AMPK Enhances Palmitoyl-CoA Inhibition
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malnoyl-CoA, which in turn controls the rate of fatty acid metabolism. ACC beta or 2 has been shown to be localized on the mitochondria in close proximity to carnintine palmitoyl transferase 1 (CPT-1), the enzyme responsible for the influx of …
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Investigating the role of ACSS2-mediated acetyl-CoA metabolism on EGFR-PI3K-PKB signalling
… availability with cellular proliferation. Acetyl-CoA is an essential metabolite that regulates key cellular processes, including *de novo* lipid biosynthesis, energy production and protein acetylation. Whilst there are multiple routes of acetyl-CoA synthesis, acetyl-CoA synthetase short …
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Studies on the Regulation of Acetyl-CoA Carboxylase and its Influence on Bacillus subtilis Differentiation
… encoding two subunits of the essential enzyme acetyl-CoA carboxylase (ACC) is a direct target of the master regulator of sporulation, Spo0A. Binding of Spo0A to a cis-element (0A box) in the promoter region of the operon has recently been identified as a strict requirement for biofilm formation …
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Regulation of Mitochondrial Function by Histone Acetylation and Mitochondrial Acetyl-CoA Levels in Saccharomyces cerevisiae
… including the mutants of the HDA1 histone deacetylase (HDAC) complex, suggesting the involvement of histone acetylation in the regulation of starvation-induced gene expression. In the second result chapter, the HDA1 complex was found to be the only HDAC in yeast that acts to restrain the …
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Structural insights into microbial one-carbon metabolic enzymes: Ni–Fe–S-dependent carbon monoxide dehydrogenases and acetyl-CoA synthases
Carbon monoxide dehydrogenase (CODH) and acetyl-CoA synthase (ACS) enzymes play crucial rules in the global carbon cycle by catalyzing reversible carbon dioxide reduction and reversible acetyl-CoA synthesis, respectively. In some cases, CODHs are monofunctional, whereas in other cases CODHs form …
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Molecular regulation of the cardiac-enriched acetyl-CoA carboxylase isoform (ACCβ) : a novel target for therapeutic interventions in cardiovascular disease
… 1 (CPT1). CPT1 is potently inhibited by malonyl-CoA, the product of the acetylCoA carboxylation reaction that is catalyzed by acetyl-CoA carboxylase (ACC). Recent studies have demonstrated that metabolic fuels such as fatty acids and glucose can function as signaling ligands, directing …
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Design, Synthesis, and Antibacterial Properties of Dual-Ligand Inhibitors of Acetyl-CoA Carboxylase and Mechanism of Action for the Antibacterial Agent Moiramide B
… A novel target for antibacterial development is acetyl-CoA carboxylase, a multifunctional enzyme that catalyzes the first committed step in fatty acid synthesis. The bacterial form of the enzyme consists of three proteins: biotin carboxylase, biotin carboxyl carrier protein, and …
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MOLECULAR REGULATION OF ATP-CITRATE LYASE
… (ACLY) is the major source of glucose-derived acetyl-CoA outside the mitochondria and is an attractive therapeutic target for metabolic disorders and cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the nucleus, …
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Phyisiological, genomic and metabolic characterization of the oleaginous yeast Papiliotrema laurentii UFV-1
… degradation, which may be alternative sources of acetyl-CoA for lipids accumulation. Analysis of expression and metabolic metabolism, including the NADP+-dependent malic enzyme, are the main sources of reducing the power for high accumulation of neutral lipids. Acetyl-CoA carboxylase activity is …
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Yeast engineering for pharmaceutical and nutraceutical purposes
… ethanol pathway plays a key role in cytosolic acetyl-CoA synthesis and redox balance of Saccharomyces, new metabolic engineering approaches not to knock out its ethanol pathway but to minimize the overflow metabolism are needed for increasing productivities of acetyl-CoA derivatives, …
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