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Showing 1 to 20 of 91 for “"acetaminophen"”.
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The Effect of acetaminophen on isoniazid metabolism
Acetaminophen (APAP, paracetamol, N-acetyl-p-aminophenol), an analgesic and antipyretic drug, causes liver necrosis in overdose. Isoniazid (INH, isonicotinyl hydrazide), an antituberculous drug, also causes liver damage in some patients at therapeutic doses. The two medications are likely to be …
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Acetaminophen-induced hepatic necrosis: possible biochemical mechanisms
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Acetaminophen Use in Newborns to Relieve Circumcision Pain
… benefit of anesthesia (Schoen & Fischell, 1991). Acetaminophen has a wide safety margin in infancy and has been shown to relieve mild to moderate pain after minor surgery using a dose of 10-15 mg/kg orally (Schoen & Fischell, 1991).<br> This study compared the administration of acetaminophen to a …
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Pharmacokinetics and Safety of Acetaminophen in Adult Horses
… gastrointestinal side effects are obviated. Acetaminophen is one of the most commonly used analgesic drugs in humans, and is readily available as an inexpensive generic over-the-counter preparation. Acetaminophen has a number of mechanisms of action that differ from NSAIDs, including actions …
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The Clinical Pharmacology of Acetaminophen in Adult Horses
… the pharmacokinetics, efficacy, and safety of acetaminophen in adult horses for use in musculoskeletal pain and pyrexia. In the first study, the pharmacokinetics and efficacy of oral acetaminophen at two different doses (20 mg/kg and 30 mg/kg) were examined in an experimentally induced lameness …
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Synthesis of Amphibian Alkaloids and Development of Acetaminophen Analogues
The focus of these studies has been toward the development of new synthetic methods and procedures for the synthesis of novel compounds with unique biological properties. This research has led to the development of two new synthetic strategies for the construction of two novel amphibian alkaloids. …
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Effects of acetaminophen on estrogen-responsive alkaline phosphatase in Ishikawa endometrial cancer cells
This study examines the effect of acetaminophen (APAP) on the estrogen-responsive gene alkaline phosphatase in Ishikawa endometrial cancer cells. Basal levels of alkaline phosphatase activity were significantly inhibited in cells treated with 0.03, 0.1, 0.3 and 1mM APAP compared to control. …
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Biotic and Abiotic Remediation of Acetaminophen with Woodchip and Biochar-amended Woodchip Adsorbents
… as a potential sorbent strategy for diffuse acetaminophen (ACT) pollution. Batch reactions were created in triplicate, supplied with 5 mM ACT, and analyzed over an eight hr period using ultraviolet spectrophotometry (298 nm). Ultraviolet absorbance readings for each time step then were …
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Acetaminophen Versus Ibuprofen for the Control of Immediate and Delayed Pain Following Orthodontic Separator Placement
… effectiveness of preemptive and postoperative acetaminophen, ibuprofen, and placebo following orthodontic separator placement. Subjects were randomly assigned to 1 of 3 conditions: placebo, 650 mg acetaminophen, or 400 mg ibuprofen. The placebo or analgesic was taken 1 hour prior to separator …
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Quantitative Determination of Acetylsalicyclic Acid and Acetaminophen by Q-NMR (Quantitative Nuclear Magnetic Resonance) Technique
… quantitatively analyze acetylsalicylic acid and acetaminophen by Proton-NMR using diethyl ether as an internal standard. The area of NMR signals shows a linear relationship with the concentration. Acetylsalicylic acid and acetaminophen were chosen as a representative drug. The method is useful …
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Evaluating the relationship between prenatal exposure to acetaminophen and phthalates and early attention and language development
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2023-12-01
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Quantitative Structure-Activity Relationship Modeling to Predict Drug-Drug Interactions Between Acetaminophen and Ingredients in Energy Drinks
… Non-transfected Hepa1-6 cells exposed to acetaminophen, pyridoxine, creatine, L-carnitine, taurine and caffeine did not reveal any significant drug-drug interactions, nor were they predicted by the model.
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Identification of Novel Regulatory Genes in Acetaminophen Induced Hepatocyte Toxicity by a Genome-Wide CRISPR/Cas9 Screen
Acetaminophen (APAP) is a commonly used analgesic responsible for over 56,000 overdose-related emergency room visits annually. A long asymptomatic period and limited treatment options result in a high rate of liver failure, generally resulting in either organ transplant or mortality. The underlying …
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
Acetaminophen (APAP) overdose causes severe hepatotoxicity and the current antidote N-acetylcysteine (NAC), has a narrow early therapeutic window. Since most patients present late to the clinic, novel late acting therapeutic options are needed. The neuronal guidance cue netrin-1 has been shown to …
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A Novel Acetaminophen Soft-Chew Formulation Produced Via Hot Melt Extrusion With Inline Near-Infrared Monitoring As A Process Analytical Technology Tool
… and optimizing the formulation. Gelatin (15%), acetaminophen (30%), saccharin (1.5%), xylitol (6.5%), sodium chloride (2%) and six different ratios of water (45-0%) and glycerol (0-45%) were used in seven formulations. The extrusion process temperature of formulation 1-6 and formulation 7 were …
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Bioactive Lipids in Nociception
… the widely used antipyretic and analgesic drug acetaminophen and (2) activators of the ion channel TRPV1, an important downstream target for inflammatory mediators, in the phospholipase C (PLC)/TRPV1 signaling pathway. Evidence is presented for a fatty acid amide hydrolase (FAAH)-dependent fatty …
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The effects of Vernonia amygdalina(Asteraceae) Delile methanolic leaf extract on markers of oxidative stress in mice treated with high doses of acetaminophen
… levels in mice treated with toxic doses of acetaminophen. The leaves of local varieties of Vernonia amygdalina Delile were extracted with 80% methanol, concentrated, dried and re-dissolved in distilled water for use. White albino mice of either sex, weighing between 20 – 31g were randomly …
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The effects of Vernonia amygdalina(Asteraceae) Delile methanolic leaf extract on markers of oxidative stress in mice treated with high doses of acetaminophen
… levels in mice treated with toxic doses of acetaminophen. The leaves of local varieties of Vernonia amygdalina Delile were extracted with 80% methanol, concentrated, dried and re-dissolved in distilled water for use. White albino mice of either sex, weighing between 20 – 31g were randomly …
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Quantum dot - molecularly imprinted polymer nanomaterials for the fluorescence sensing of selected pharmaceutical and personal care products
… in aquatic compartments of triclosan (TCS) and acetaminophen (AC) which fall within the pharmaceutical and personal care products (PPCPs) subclass of emerging chemical pollutants (ECPs). Semiconductor quantum dots possess significant advantages such as high fluorescence intensity, long-term …
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