Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"accumbens"”.
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The neural associations of nucleus accumbens septi.
Massachusetts Institute of Technology. Dept. of Psychology. Thesis. 1972. Ph.D.
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The Regulation of Effort Exertion by the Nucleus Accumbens Core
<p> The nucleus accumbens core is believed to play an important role in regulating effort exertion. Effort can be explained as the energetic costs of an action relative to its long-term benefits. Using fixed-ratio schedules of reinforcement, different effort requirements can be imposed upon mice, …
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Role of Dopamine of Nucleus Accumbens In Behavioral Sensitization to Methylphenidate
… of the mesocorticolimbic system is the nucleus accumbens (NAc), which is a key structure linking motivation and action. In particular, the dopaminergic innervations of the Nac are considered to be essential in regulating motivated states of behavior such as goal-directed actions, stimulus-reward …
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Quantitative analysis of the extracellular glutamate concentration of the nucleus accumbens
… from the extracellular fluid of the nucleus accumbens (NAS). Sample concentrations of dopamine and glutamate were assayed using high performance liquid chromatography followed by electrochemical detection. Sample glutamate concentrations decreased and then increased during the first ten to …
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REGULATION OF DOPAMINE TERMINAL RELEASE IN THE NUCLEUS ACCUMBENS: IMPLICATIONS FOR ALCOHOL ADDICTION
… consequences. Dopamine signaling in the nucleus accumbens is thought to encode reward and reinforcement, and aberrations in dopamine signaling are suggested to mediate some of the maladaptive motivational behaviors associated with addiction. Measuring dopamine signaling in nucleus accumbens …
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Selective memory impairments produced by transient lidocaine-induced lesions of the nucleus accumbens
… pathways from the hippocampus to the nucleus accumbens (N.Acc.), but the functional significance of this interaction remains unclear. The delayed spatial win-shift radial arm maze task has been used as a selective behavioral measure of damage to the hippocampal system, whereas the cued …
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The Effects of Nucleus Accumbens Opiate and Adenosine Receptor Activity on Appetitive Operant Learning
… of both of these receptors within the nucleus accumbens affect motivational aspects of instrumental conditioning and food intake. The nucleus accumbens has previously been shown to be important for the learning of appetitive instrumental conditioning tasks through NMDA receptor activity …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
The nucleus accumbens (NAc) consists primarily of GABAergic neurons, and is an essential integration site within the natural reward-pathway, which is ‘hijacked’ by drugs of abuse. We have previously shown for accumbal medium spiny neurons (MSNs) that α2-subunit containing GABAA receptors …
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The effects of quinpirole in eliciting 50 kHz calls from the rat nucleus accumbens /
… on dopaminergic activity at the nucleus accumbens shell (Burgdorf, Knutson, Panksepp & Ikemoto, 2001; Thompson, Leonard & Brudzynski, 2006). The utilization of d-amphetamine (a non-selective dopamine agonist) in these studies does not address the specific dopamine receptor types involved. …
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Chronic stress-dependent activation of somatostatin neurons in the nucleus accumbens facilitates maladaptive eating behaviors
… stress exposure. In addition, the nucleus accumbens (NAc), a key component in the neural circuitry of reward, is also an established neural substrate susceptible to the effects of stress. Given the cellular complexity in NAc, identifying the neuronal subtypes that are selectively involved …
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Effects of dopamine depletion in the nucleus accumbens on lateral hypothalamic self-stimulation in the rat
… changes in the dopaminergic input to the nucleus accumbens (NAcc). We reexamined the effects of dopamine depletion induced by 6-hydroxydopamine (6-OHDA) on lateral hypothalamic (LH) self-stimulation using within-subject analysis. To minimize motor deficits due to destruction of the dorsal striatal …
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Dopamine responsiveness in Nucleus Accumbens Shell and Core and Prefrontal Cortex during operant behavior for sucrose
… terminal DA areas: shell and core of nucleus accumbens (NAc) and medial prefrontal cortex (mPFCX), using a food self-administration paradigm. Rats were trained to acquire sucrose self-administration under a Fixed Ratio 1 (FR 1) or FR5 variable time out schedule of responding. After training, …
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Age-dependent effects of chronic amphetamine on prelimbic-nucleus accumbens circuit function and goal-directed behavior
… on HFS-induced plasticity in the PL-nucleus accumbens circuit. These studies revealed unique behavioral changes and neuroadaptations following adolescent AMPH exposure. Our results are consistent with the hypothesis that adolescent brain is more vulnerable to the detrimental effect of drugs.
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Investigation of the role of the nucleus accumbens in amphetamine-induced 50 kHz ultrasonic vocalizations in the rat
… in rats. In particular, the shell of the nucleus accumbens is associated with generation of frequency modulated 50 kHz calls (a specific type of 50 kHz call which can be subdivided into various subtypes). There is also evidence that amphetamine administered systemically preferentially increases …
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Dissociating Roles for the Nucleus Accumbens Core and Shell in Priming-, Cue-, and Stress-Induced Reinstatement of Food-Seeking Behavior
… affected by manipulation of the nucleus accumbens subregions, the core and shell. To determine if the nucleus accumbens core and shell uniquely contribute to the reinstatement of food-seeking, the present studies assessed the behavioral effects that resulted from inactivation of the core …
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MUSCARINIC ACETYLCHOLINE M2 RECEPTORS INCREASE IN CHOLINERGIC INTERNEURONS OF THE NUCLEUS ACCUMBENS FOLLOWING BINGE ALCOHOL DRINKING IN C57BL/6J MICE
… the cholinergic interneurons in the nucleus accumbens, a brain region that is affected by drugs of abuse including alcohol. Cholinergic interneurons in the nucleus accumbens were of particular interest in this study since previous findings have reported that these neurons are involved in …
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Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
… increase in dopamine overflow in the nucleus accumbens compared to non D<sub>2</sub>-primed rats administered amphetamine. Both D1 and D2 antagonism were effective at blocking amphetamine-induced increases in dopamine overflow. These results show that neonatal quinpirole treatment enhances …
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A Systematic Investigation of Whether Cannabinoids and Opioids Interact in the Nucleus Accumbens Shell to Differentially Impact Feeding Patterns on a Palatable Diet
… of both cannabinoids and opioids in the nucleus accumbens appear to differentially impact eating. Therefore, the nucleus accumbens may be one neural location of the observed systemic effects of these neurochemical messengers. These experiments sought to investigate the effects of opioids and …
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Amphetamine Sensitization and <em>in vivo</em> Microdialysis of the Nucleus Accumbens Core of Adult Male and Female Rats D2-Primed as Neonates.
… was taken via microdialysis from the nucleus accumbens core and was analyzed for dopamine content. Analysis revealed D<sub>2</sub> priming produced a 300% increase of dopamine release in the nucleus accumbens core in response to amphetamine compared to controls. These results suggest that …
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