Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 41 for “"accessory proteins"”.
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The Effects of Accessory Proteins on ENaC Function
… and pESC-Leu/γ in order to further characterize accessory proteins in yeast screens using the heterotrimeric channel. An antibody screen against the subunits of ENaC was then performed using Murine Principle Kidney Cortical Collecting Duct (mpkCCD) cells as a means of identifying a primary …
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Evaluation of the potential functions of Avian paramyxovirus Accessory proteins
… APMV 2-12. APMV expresses six structural and two accessory proteins. The functions of APMV accessory proteins (V and W) are not fully established. Only the function of V protein in NDV is studied so far. V protein was found to be an IFN antgonist and a major virulent determinant of NDV. In this …
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Analyses of tau and radixin : two accessory proteins of the cytoskeleton in mammalian cells
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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Identification of Accessory Proteins and Their Impact on the Expression of the Epithelial Sodium Channel (ENaC)
… blood pressure. Though there have been several accessory proteins known to regulate ENaC function, there are still questions to be answered about the role other proteins play in ENaC trafficking and assembly. Understanding the mechanisms behind ENaC regulation will potentially provide insight …
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Specialised Effectors and Accessory Proteins Important in the Antibacterial Type VI Secretion System of <i>Serratia marcescens</i>
… systems efficiently translocating particular proteins to the external medium or directly into competitor target cells. Recently, much progress has been made towards understanding the role and mechanism of the Type VI secretion system (T6SS). The T6SS is widespread in Gram-negative bacteria and …
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Recombinant Expression and Assembly of Methyl Coenzyme-M reductase
… a conserved mcrBDCGA gene cluster, which encodes accessory proteins McrD and McrC. These are believed to be involved in the assembly and activation of MCR, respectively. However, one or both accessory proteins are often omitted from the operon in other MCR-containing archaea as is the case in …
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DNA -Protein Interactions in the CTnDOT Excisive Intasome
… studied to date. Excision requires multiple accessory proteins. Exc is one protein required for excision, however, its function is unknown. In an attempt to determine a role for Exc, the native wild type Exc protein was purified. These studies indicated that Exc might interact with IntDOT …
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An expanded search for RNA-programmable genomic engineering effectors
… to CRISPR-associated spacer acquisition proteins Cas1 and Cas2, this approach was seeded on CRISPR arrays alone. What resulted was the discovery of a potential new Class 2 CRISPR system, with two subtypes as characterized by distinct putative accessory proteins. Follow-up experimental …
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… and stress response. The melanocortin receptor accessory proteins (MRAP1 and 2) influence MC receptor transport and signalling. The MCs are activated by proopiomelanocortin (POMC) derivatives: alpha-, beta-, and gamma-melanocyte stimulating hormones and adrenocorticotrophic hormone; while agouti …
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Investigation of Diverse CARF Effectors in Type III CRISPR - Cas Immunity
… into the CRISPR array by CRISPR-associated (Cas) proteins Cas1 and Cas2.The CRISPR locus also encodes either a multi-protein complex or single protein with nuclease activity. Upon infection via phage or plasmid, the host will transcribe the CRISPR array, generating guide RNA sequences called …
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Analyzing the Interactions Between Xenopus tropicalis MC2R, MC5R, and the MRAPs: Modeling the Regulation of Frog Interrenal Cells
… receptors and two melanocortin receptor accessory proteins are expressed: MC2R, MC5R, MRAP, and MRAP2. The MRAPs have an opposite effect on the cell surface expression of MC2R and MC5R. In mammals, MRAP aids MC2R but inhibits MC5R cell surface expression. This thesis aims to explore the …
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Modulation of GR transcriptional signalling by HIV-1 Vpr insights into regulation by progestins
… with glucocorticoids (GC). One of the HIV-1 accessory proteins, Vpr, is highly immunosuppressive and contributes to suppression of the immune system thereby creating an environment favourable for viral proliferation. Vpr has been previously reported to act as a GR co-activator on …
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Single-molecule fluorescence resonance energy transfer study of SNARE-mediated membrane fusion
… many processes that rely on some form of fusion. Proteins called soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) play a central role in fusion processes which is also regulated by many accessory proteins, such as synaptotagmin, complexin and Munc18. By a new lipid …
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The Tansmembrane Associations of HIV-1 Vpu and its Human Targets
… innate immune response through the expression of accessory proteins that modulate the activity of immune system proteins. The HIV-1 protein Vpu functions to downregulate a number of host cell surface proteins within infected cells. For several target proteins, including the NTB-A and PVR receptors …
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Investigation of Escherichia coli [NiFe]-Hydrogenase Maturation
… requires at least seven dedicated accessory proteins to assemble and insert the components of the NiFe(CN)2CO catalytic site. The penultimate maturation step is the delivery of nickel to a primed hydrogenase precursor protein, a process that is accomplished by the metallochaperone …
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The streptomyces cytoskeletal protein (Scy) is a key component of the tip organising centre for polarized growth in streptomyces coelicolor
… cytoskeletal homologues as well as a number of accessory proteins unique to prokaryotes. As cell shape determination is dependent on the sites of insertion of new cell wall material, this is characteristically organised and driven by cytoskeletal proteins. Streptomyces coelicolor hyphal growth …
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Spatio-temporal properties of membrane-localized actin nucleating complexes
… of bundled actin filaments, actin regulatory proteins are believed to assemble a distal 'tip complex' which stimulates actin nucleation at the membrane. However how these regulators collectively behave in a macromolecular complex still remains poorly understood. To understand the …
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Mechanism of Mcm10 function during DNA replication
… in the recruitment of DNA polymerases and accessory proteins to begin DNA synthesis. Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukaryotic DNA replication initiation. Mcm2-7 helicase-activation requires binding of the helicase-activating proteins, Cdc45 and …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… of Nav channels is regulated by a number of accessory proteins. Very few proteins regulate the functional properties of Nav channels as potently as the intracellular fibroblast growth factor 14 (FGF14). FGF14 is a biologically relevant accessory protein of the neuronal Nav channel complex …
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