Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"abscessus"”.
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Gyermekkori köhögés, pneumonia és abscessus
… súlyos szövődmények kialakulását eredményezheti, abscessus-t vagy akár sepsis-t is okozhat. Szerencsére, a gondos anamnézis felvétel, az alapos fizikális vizsgálat, a képalkotó eljárások alkalmazása és az időben megkezdett megfelelő terápia, ezen komplikációk kialakulásának valószínűségét a …
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Developing novel therapies for Mycobacterium abscessus
Mycobacterium abscessus (M. abscessus) is a rapid growing non-tuberculous mycobacteria (NTM) that is increasingly recognised as a major pathogen owing to its inherent resistance to a wide range of the currently available antibiotic therapies. In particular, it causes problems in patients with …
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Tackling Mycobacterium abscessus infection in Cystic Fibrosis
Mycobacterium abscessus is an emerging pathogen with infections increasing worldwide, especially among Cystic Fibrosis (CF) patients. During my PhD, I studied key aspects of the biology of M. abscessus spp.; particularly, I studied host-pathogen interactions, antimicrobial resistance mechanisms, …
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Creating effective drug discovery methods in Mycobacterium abscessus
… tools in a single bacterium, Mycobacterium abscessus. M. abscessus is an emergent human pathogen which causes lung infections in those with underlying lung conditions, most significantly patients with cystic fibrosis. M. abscessus is also highly drug resistant, and currently has very limited …
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Investigating the role of sufT in Mycobacterium abscessus using CRISPRi
Mycobacterium abscessus (M. abscessus) is a rapidly growing non-tuberculous mycobacterium (NTM) that causes a wide range of infections including pulmonary M. abscessus disease. Treatment of M. abscessus infections is challenging because the mycobacterium is intrinsically resistant to different …
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Analysing M. abscessus-macrophage interactions and investigating treatments for M. abscessus and S. aureus intracellular bacterial infections, using a continuously growing, primary cell model of lung alveolar macrophages
INTRODUCTION - Mycobacterium abscessus (MAB) and Staphylococcus aureus (SA) are bacterial pathogens capable of causing a range of infections in humans, and pulmonary infections are significant amongst them. During pulmonary infection, alveolar macrophages (AMs), as sentinel immune cells of the …
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Evolutionary Genomics of Cystic Fibrosis and Nosocomial Pathogens of the Mycobacterium abscessus species complex
The $\textit{Mycobacterium abscessus}$ species complex (MABSC) consists of three subspecies, $\textit{M. a. abscessus}$, $\textit{M. a. massiliense}$ and $\textit{M. a. bolletii}$. All three of these subspecies are capable of causing opportunistic pulmonary and skin and soft tissue infections in …
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A fragment-based approach towards understanding molecular recognition of 4’-phosphopantetheine adenylyltransferase from Mycobacterium abscessus
… adenylyltransferase (PPAT) from Mycobacterium abscessus (Mabs). A fragment screen of the Abell laboratory 960-member library was conducted by Dr Sherine Thomas (Department of Biochemistry, University of Cambridge) and identified 15 hits validated by X-ray crystallography. The structural …
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Targeting Mycobacterium abscessus Infection in Cystic Fibrosis: A Structure-guided Fragment-based Drug Discovery Approach
… years have seen the emergence of Mycobacterium abscessus, a highly drug-resistant non-tuberculous mycobacterium, which causes life-threatening infections in people with chronic lung conditions like cystic fibrosis. This opportunistic pathogen is refractory to treatment with standard …
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Adherence and Biofilm Formation of Mycobacterium avium, Mycobacterium intracellulare, and Mycobacterium abscessus in household plumbing
… Mycobacterium intracellulare, and Mycobacterium abscessus, were examined for adherence and biofilm formation on surfaces common to household plumbing systems, including glass, copper, stainless steel, polyvinyl chloride, and galvanized steel. All experiments were conducted with sterile, …
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Utilization of Model-Based Approaches to Maximize Efficacy of Antibiotics for the Treatment of Mycobacterium abscessus Pulmonary Infection
<p>Prevalence and incidence of Mycobacterium abscessus (Mab) pulmonary infections have increased and been recognized as a major cause of mortality, particularly in certain patient populations, such as cystic fibrosis (CF) patients. Due to the intrinsic multidrug resistance mechanisms and biofilm …
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Identifying cross-species regimens for the treatment of rapid-growing and slow-growing nontuberculous Mycobacterium pulmonary infections
… especially Mycobacterium avium and Mycobacterium abscessus, are increasingly significant causes of chronic pulmonary disease. Current treatments are lengthy and often ineffective, with culture conversion often below 60% in refractory patient populations. Due to the close biological relationship …
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Design, Synthesis, and Evaluation of Novel Antimycobacterial Agents With Enhanced Pharmacokinetic Profiles
… mycobacteria (NTM) such as the M. avium and M. abscessus complexes (MAC and MABSC, respectively) are opportunistic pathogens found ubiquitously in the environment. NTM infections have increasing prevalence in patients with structural lung diseases, including chronic obstructive pulmonary disease …
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Exogenous Lipoid Pneumonia in Children: A Systematic Review and Case Series from South Africa
… polymicrobial (6/12) and Mycobacterium abscessus (2/12) co-infection. Antibiotics, systemic corticosteroids and therapeutic partial lung lavage were interventions in all, 8 and 5 patients respectively. Median time to clinical resolution was 1.1 months IQR (0.5-8.0) with radiological …
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Inhibition of enzymes from mycobacteria using fragment-based approaches
… methyltransferase (TrmD) from Mycobacterium abscessus (Mab). With Mtb fumarase a high-throughput screening (HTS) hit was used to design a small library of fragments in a deconstruction-reconstruction approach. These fragments were screened using a range of both biochemical and biophysical …
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Design and Synthesis of Antimycobacterial Agents
… in a phenotypic screen against *Mycobacterium abscessus*, producing four lead compounds, two of which, **13H8** and **14F8**, were chosen for further development. The first project in this dissertation aimed to improve the biological activity of the propiolic ester lead **13H8**, by building on …
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Protein engineering of botulinum toxins with enhanced ganglioside binding capacity A biophysical and computational approach
… project modelling the proteome of Mycobacterium abscessus.
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Optimization of N-(1-Adamantyl)-3-Aryl Acetamides as Novel Antimycobacterial Agents
… Generally, activity was reduced against M. abscessus for this series. However, three lead acetamides (229, 218, 223) were able to further improve Mtb activity, all achieving an Mtb MIC = 0.125 μg/mL. Additionally, two lead acetamides (220 and 231) were identified with acceptable anti-Mtb …
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Targeting infectious species by Structure-guided Fragment-based Drug Discovery and in silico approach
… infection threats. For instance, Mycobacterium abscessus (Mab) is a rapidly growing multidrug-resistant species of nontuberculous mycobacteria (NTM) in addition to the well-characterised highly virulent species of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella …
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DESIGNING BIOMIMETIC NANOPARTICLES TO TACKLE INTRACELLULAR PATHOGENS
… bacterial pathogens such as Mycobacterium abscessus (Mab) continue to evade therapeutic clearance by creating intracellular reservoirs within host macrophages. Conventional drug delivery systems often fall short due to their lack of precision, limited intracellular access, and rapid …
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