Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"abortive infection"”.
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Phage host range and definition of genes implicated in Type III toxin-antitoxin-mediated abortive infection
… themselves. One of these systems is termed abortive infection (Abi) where, upon phage infection, an Abi system may be activated which initiate a bacteriostatic or bactericidal response. While the infected bacteria do not obviously benefit from the activation of these systems, the cessation …
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Conflict between bacteriophages and a mobile genetic element in bacterial immunity
… a phage defense system, spbK, which, upon phage infection, causes cell death prior to generating phage progeny. This mechanism of phage defense is considered abortive infection and protects populations of cells via altruistic cell death of infected cells. I show that during SpbK-mediated abortive …
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Recovering from Dormancy: Fixation of CSM6-Inducing Spacers in the Bacterial Population
… its adaptive nature in which memories of prior infections are acquired and stored. CRISPR loci contain clusters of characteristic repeat sequences separated by short "spacer" sequences which are derived from prior invading genetic material and form the basis of these acquired memories. During an …
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Characterization of ToxINPa-sensitive bacteriophages of Serratia sp. ATCC 39006
Abortive infection (Abi) is an anti-phage mechanism in which a bacterium initiates its own death upon phage infection. This prevents or decreases the production of phage progeny and protects clonal siblings in the bacterial population by an act akin to an “altruistic suicide.” Abortive infection …
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Mechanisms of phage detection by bacterial innate immune proteins
… mechanisms to protect themselves from phage infection, such as restriction modification, CRISPR-Cas, and abortive infection (Abi) systems. Because Abi systems function through killing infected cells to protect the bacterial population, they must stay inactive prior to infection, but rapidly …
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The Biological Burden of Antibiotic Resistance in Staphylococcus aureus
… operon and two ORFs with homology to the abortive infection protein AbiK of <em>Lactococcus lactis</em>. Pairwise competition experiments show that 8325-4 grows considerably faster carrying pS A2 with <em>blaZ</em> mutations than it does with unmutated pSA2 and almost as rapidly as 8325-4 …
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Genetic mechanisms contributing to antimicrobial resistance: gene repression in Mycobacterium, gene transfer in Salmonella, and phage sensitivity in Escherichia
… drug bedaquiline in M. intracellulare lung infections. Based on previous work, MmpT5 is a TetR transcription factor hypothesized to repress expression of the downstream Resistance Nodulation Division (RND) efflux pump mmpSL. To test this, we assembled multigene constructs on a plasmid with …
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ToxIN-mediated resistance to and cell-free production of Salmonella bacteriophages
… ToxIN, a resistance system which aborts phage infection, is present in outbreak strains of Salmonella; confers resistance to the broad host range phage FelixO1 and other phage isolates; and is found in the whole-genome sequences of numerous Salmonella serovars and in other human pathogens. The …
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Ancient Immune Systems: Sensing and Signaling in Bacterial-Phage Conflict
… the mechanisms by which they disrupt phage infection [3]. Nonetheless, major gaps persist in our understanding of how bacterial immune systems recognize bacteriophage infection to trigger immunity. This dissertation examines the molecular basis of this sensing process, offering new …