Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 984 for “"aberrant"”.
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Aberrant segregation in human populations
Three cases of aberrant segregation in humans were considered. The first was a possible case of non-random assortment of chromosomes and meiotic drive. Separating children of fathers of given heterozygous ABO genotypes into sperm classes (classified by the ABO gene received from the father), for …
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Molecular recognition of aberrant translation
… mechanisms manage to specifically identify an aberrant event amid widely heterogenous normal physiologic states. This question forms the basis of this thesis, which is focused on understanding the molecular principles that determine accurate recognition of aberrantly slow ribosomes. To address …
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Aberrant Ras/MAPK signaling in skeletal development
… such as Noonan Syndrome (NS), that are caused by aberrant germline Ras/MAPK signaling. One hallmark of these developmental syndromes is a defect in the skeletal development of the patients. However, the in vivo role of MAPK signaling during bone development is still controversial, with some …
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Aberrant and Alternative Splicing of von Willebrand Factor
… exon 26 induces transcription of three in-frame aberrant splice forms (1) skipping exon 23, (2) skipping exon 26, (3) skipping exons 23 & 26 together, leading to Type 1 VWD. In Family 2, the canonical c.5842+1G>C mutation causes VWD through production of intracellularly retained in-frame VWF, …
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Petr Herel: the Artist's Book as Aberrant Object
… dissertation is to present the artist’s book as aberrant object. This sustained investigation of the artist’s book draws upon interdisciplinary theories from art history, anthropology, linguistics, economics, socio-cultural studies, and material studies to examine the artist’s book’s place in art …
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Petr Herel: the Artist's Book as Aberrant Object
… dissertation is to present the artist’s book as aberrant object. This sustained investigation of the artist’s book draws upon interdisciplinary theories from art history, anthropology, linguistics, economics, socio-cultural studies, and material studies to examine the artist’s book’s place in art …
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Effects of aberrant visuo-vestibular information on higher cognition
… execution of balance system functions based on aberrant space-motion information. The cardinal manifestations of balance disorders include instability and dizziness. Higher cognitive dysfunction is also a possible sequela, but the mechanisms that give rise to it are unclear. Prevailing theory …
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Diseased Thyrocytes Have Aberrant Communication and TNF Receptor Secretion
… thyroiditis in MRL-lpr/lpr mice. We have found aberrant connexin expression in thyroid tissue from these mice. The abnormal gap junction assembly persisted when the cells were removed from the inflammation site and cultured <em>in vitro</em>. Primary thyrocyte cultures from these mice were also …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
… length vRNAs and cRNAs, the FluPolA synthesizes aberrant RNA products, such as defective interfering RNAs (diRNAs) and mini viral RNAs (mvRNAs). The innate immune system serves as the body's primary defence against viruses. Within this intricate defence network, RIG-I is responsible for detecting …
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Aberrant self-promotion versus Machiavellianism: a differentiation of constructs
… by Christie (1970a) and those exhibiting the aberrant self-promotion pattern proposed by Gustafson and Ritzer (1995). The aberrant self-promoter (ASP) was defined as having a high degree of narcissism, combined with a low need to appear conventionally "nice" along with pronounced antisocial …
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Aberrant self-promotion versus Machiavellianism: a discriminant validity study
… evidence of discriminant validity for the aberrant self-promotion construct proposed by Gustafson and Ritzer (1994a). The study attempted to differentiate the aberrant self-promotion construct from the Machiavellianism construct proposed by Christie (1970a). The aberrant self-promoter (ASP) …
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Technological Innovation in Architecture: The Role of the Aberrant Practitioner
… and authored books), I will present how the aberrant creative process which the economist Joseph Schumpeter described as the ‘innovating entrepreneur’ can enlarge the palette of technological possibilities for the architect and define a unique role within the construction industry. The …
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Aberrant Communication and Protein Kinase C in Experimental Autoimmune Thyroiditis
… other that physical disruption were influencing aberrant communication in EAT. By studying protein kinases, we found pKC activity was increased in diseased thyrocytes with enhanced expression of several pKC isozymes and induction of two disease-specific pKC isozymes. The increase in pKC activity …
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Perceptual and acoustic impacts of aberrant properties of electrolaryngeal speech
… the perceptual and acoustic impacts of several aberrant properties of EL speech, with the overall goal of using the results to direct future EL speech improvement efforts. Perceptual experiments conducted by having 10 listeners judge the naturalness of differently enhanced versions of EL speech …
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Ego Depletion-Induced Aberrant Driving in the Post-Work Commute
… of attention and motivation with post-work aberrant driving. Results indicated that an ego depleted state might impair attention and motivation but not driving safety in the commute. Instead, the results pointed to the person-level factor of trait self-control as potentially having a greater …
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Novel Monte Carlo Approaches to Identify Aberrant Pathways in Cancer
… regulatory networks and 2) uncovering of aberrant intracellular signal transduction pathways. We propose a robust method, called GibbsOS, to identify condition specific gene regulatory patterns between transcription factors and their target genes. A Gibbs sampler is employed to sample …
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ROLE OF PINCH IN ABERRANT TAU PHOSPHORYLATION IN HIV CNS DISEASE
… of protein quality control and accumulation of aberrant proteins, such as hyperphosphorylated Tau (hpTau). In this context, we have discovered a new signaling connection between age-related neurodegeneration and HIV involving the PINCH protein. Particularly interesting new cysteine …
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Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia
… have been reported to harbor multiple genes aberrantly silenced by promoter hypermethylation and as a result, cytosine analogs known to inhibit the DNA methylation machinery are currently being evaluated in clinical trials. As such, the general goal of this thesis was to identify genes …
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