Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"aHUS"”.
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Genetic Factors Associated with Anti-Factor H Autoantibodies in Atypical Hemolytic Uremic Syndrome (aHUS)
Atypical hemolytic uremic syndrome (aHUS) is a rare form of thrombotic microangiopathy characterized by renal failure and determined by genetic and acquired defects of alternative pathway (AP) of the complement system. Autoantibodies against factor H (anti-FHs), a regulator of the AP, were reported …
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Genetic, molecular and functional analyses of factor I - an inhibitor of the complement system
… and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional assays. The mutations are homozygous or compound heterozygous in patients with complete FI deficiency and the mutations mostly …
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Studies of EHEC and the complement system in renal diseases
… mutations or auto-antibodies (atypical HUS, aHUS). EHEC is a non-invasive highly virulent bacterium. In order to gain access to the circulation it first damages the intestinal mucosa. The mechanism of damage and the bacterial factors involved were addressed. Abundant cell death by apoptosis …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
… deficiency. Atypical hemolytic uremic syndrome: aHUS) is a thrombotic microangiopathy that primarily affects the kidneys. This disease is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Heterozygous mutations in the regulatory proteins Factor H, CD46 …
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Investigation of Phosphatidylinositols and Phosphoinositides Using Matrix- Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
… including atypical hemolytic uremic syndrome (aHUS), necessitating a deeper understanding of their spatial distribution and abundance. Given the low concentration of PIs and PIPs, the study aimed to optimize MALDI-MSI for their detection. Thus, various chemical matrices necessary for the …
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Development and implementation of a framework to aid the transition to proactive maintenance approaches on air handling units in the industrial setting
… maintenance of HVAC equipment, specifically AHUs in industrial facilities, to make progress towards climate goals. HVAC systems account for 14% of global energy consumption, with the potential to increase efficiency by 20% by addressing energy-wasting faults according to Roth et al. However, …
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Impact of Thermally Activated Building Systems (TABS) in Office Buildings
… 2012). HVAC systems include Air Handling Units (AHUs) to deliver the conditioned air and provide dehumidification. In contrast, TABS consists of conditioned water pumped through pipes embedded within the building's floor, walls, and ceilings to transfer heat between internal wall surfaces. The …