Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 445 for “"a2"”.
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Synthesis of thromboxane A2 analogues.
… the project was to synthesize novel thromboxane A2 analogues which would be potential thromboxane A2 antagonists. Three thromboxane A2 analogues were synthesized, methyl 7-[-5-(3-hydroxy-1-(E)-octenyl)-2-methylbicyclo[3.3.1]non-2-en-9-yl]-[syn]-(+/-)-5-(Z)-heptenoate, methyl …
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Spin parity studies of the eta pi decay of the A2 meson and investigation of the A2 production mechanism in the reaction pi-minus proton goes to A2-minus proton
… mode of the A-meson produced in the reaction A2-p -A2-pare presented. Data for the analysis are drawn from bubble chamber experiments between 3.9 and 16 GeV/c. The analysis favors JP=Z+ for both the upper and lower regions of the AZ' Possible evidence for a weakly produced JP=l daughter state …
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MOLECULAR PHYSIOLOGY OF THROMBOXANE A2 GENERATION IN PLATELETS
… leukocyte aggregation formation. ThromboxaneA2 (TXA2) is a potent platelet agonist generated through arachidonic acid metabolism in platelets. TXA2 thus, generated after platelet activation acts as a positive feedback mediator along with ADP. Under physiological conditions, platelet …
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Phospholipase A2 Induced Monocyte Chemotaxis to Apoptotic Cells
… of the reaction catalyzed by the phospholipases A2 (PLA2) have been shown to induce monocyte chemotaxis either directly or indirectly. Some investigators have implicated a cytosolic calcium-independent PLA2 (iPLA2) in the production of these products during apoptosis. However, a recent report …
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Regulation of Secretory Phospholipase A2 by Thyroid Hormone
… and atherosclerosis. Secretory phospholipase A2 group IIA (PLA2g2a) enhances the progression of several chronic inflammatory diseases including arthritis and atherosclerosis. The potential linkage of hypothyroidism with inflammation led us to examine the modulation of sPLA2 expression by …
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Microprojectile-mediated transformation of Ornithogalum thyrsoides hybrid A2
… O. thyrsoides x O. dubium hybrid, designated A2.
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Spin Parity Studies of the Eta-Pion Decay of the A2-Meson and Investigation of the A2-Meson Production Mechanism in the Reaction Negative Pion-Proton Going to Negative A2-Meson and Proton
… 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7121164.PDF: 2552504 bytes, checksum: c12ac4d1662826dcd1757fc0c5d7c0a4 (MD5) Previous issue date: 1971
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Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
… breast cancer. The receptor of thromboxane A2 (TxA2), TP, is a member of the G-protein coupled receptor family. Increased expression of TP at RNA level was found to correlate with a poor prognosis in breast cancer patients; however, it is unknown how TP expression and activities are involved …
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Mechanism Governing the Cellular Susceptibility to Secretory Phospholipase A2
Secretory phospholipase A2 (sPLA2) is an important part of apoptosis and disposal of damaged and dying cells. However, healthy cells are not susceptible to attack by sPLA2. Recent studies have focused on membrane properties necessary to induce susceptibility in both artificial and biological …
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Expanding the Role of Criterion A2 in Posttraumatic Stress Disorder
… an individual’s subjective response, criterion A2. This study investigated the importance of criterion A2 and other intense negative emotions in the development of PTSD. Self-report measures were used to determine the presence or absence of the event criteria A1 and A2, PTSD symptoms, and …
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Expanding the Role of Criterion A2 in Posttraumatic Stress Disorder
… an individual’s subjective response, criterion A2. This study investigated the importance of criterion A2 and other intense negative emotions in the development of PTSD. Self-report measures were used to determine the presence or absence of the event criteria A1 and A2, PTSD symptoms, and …
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Mechanisms by Which Apoptotic Membranes Become Susceptible to Secretory Phospholipase A2
… to hydrolysis by secretory phospholipase A2 (sPLA2). To study the relevant mechanisms, a simplified model of apoptosis using a calcium ionophore was first applied. Kinetic and flow cytometry experiments provided key observations regarding ionophore treatment: initial hydrolysis rate was …
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Measurement of the Proton A1 and A2 Spin Asymmetries: Probing Color Forces
The Spin Asymmetries of the Nucleon Experiment (SANE) measured the proton spin structure function g2 in a range of Bjorken x, 0.3 < x < 0.8, where extraction of the twist-3 matrix element dp2 (an integral of g2 weighted by x2) is most sensitive. The data was taken from Q2 equal to 2.5 GeV 2 up to …
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Mechanisms of Cell Surface Trafficking and Potential Functions of Extracellular Annexin A2
Annexin A2 (AnxA2) belongs to a family of Ca2+-dependent phospholipid binding proteins. AnxA2 is abundantly expressed in the cytosol of many different cell types and is translocated to the outer surface of the plasma membrane in response to elevated concentrations of intracellular Ca2+. It is known …
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Development and Characterization of A Bi-Specific Antibody Targeting Hla-A2/Pr1
… strategy targeting myeloid leukemia antigen, HLA-A2 restricted peptide PR1.Previously, we have conducted pre-clinical development and humanization of a T cell receptor-like monoclonal antibody (h8F4) that targets PR1/HLA-A2 and eliminates AML xenografts by antibody-dependent cellular cytotoxicity …
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The Role of Secretory Phospholipase A2 Group IIA in Obesity and Metabolism
<p>Secretory phospholipase A2 group IIA (PLA2G2A) is a member of a family of secretory phospholipases previously implicated in inflammation, atherogenesis, and antibacterial actions. These enzymes hydrolyze glycerophospholipids at the sn-2 position releasing lysophospholipids and fatty acids. …
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The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… of neuronal cell death. Cytosolic phospholipase A2 (cPLA2) belongs to a family of phospholipases that act as the principle producers of arachidonic acid (AA) in cells. During the process of inflammation, AA released from phospholipids is metabolized by cyclooxygenase-1[slash]2 (COX1[slash]2) and …
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Lipoprotein-associated phospholipase A2 (Lp-PLA2) Impact and role as cardiovascular risk marker
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. Specific aims were to explore the …
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