Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"a-MSH"”.
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Effect of age and pregnancy on the murine melanocortin system in the female reproductive system
… in the potency of MC3 to ACTH (1-39), and NDP-a-MSH MC3 in the presence of MRAP1. These studies also show a reduction in sensitivity of MC3 to ACTH (1-39) with 1:1 co-expression of MC3: MRAP2 whilst a 1:10 MC3: MRAP2 expression ratio increased the sensitivity of MC3 to both ACTH (1-39) and …
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Synthesis and activity of tyrosinase in mouse skin melanocytes
… does not synthesize melanin) The effect of a-MSH on tyrosinase activity was initially investigated. A skin culture tyrosinase assay that made it possible to measure the effect of α-MSH on the activity of this enzyme in vitro was first developed. It was found that α-MSH activated the wild type …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… human melanocytes, I demonstrated that alpha-MSH induced tyrosinase expression and activity and TRP-1, TRP-2 expression were suppressed by IFN-γ, which resulted from the inhibition of MITF expression, upstream molecule of tyrosinase. Moreover, the inhibitory effects on MITF expression by IFN-γ …