Global ETD Search
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Showing 1 to 3 of 3 for “"Zscan4"”.
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ZSCAN4 AND REPLICATION STRESS: SAFEGUARDING GENOME STABILITY IN MOUSE EMBRYONIC STEM CELLS
… cells (mESC) to RS induces the expression of Zscan4, a marker of the 2C stage in mouse embryo development. Depletion of Zscan4 in mouse zygotes reduces the number of blastocysts formed, which eventually fail to grow and implant. ZSCAN4 also plays a crucial role in mESC by contributing to …
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The role of inherited determinants and embryonic-extraembryonic cell interactions in models of mammalian embryogenesis
… activity and the expression of ZGA-related genes Zscan4, Eif1a and Sp110 in the mouse embryo. Overexpression of a degradation-resistant cyclin B3 resulted in the elongation of the S-phase at the expense of the G2 phase in the 2-cell embryo and a suppression of ZGA-related genes. This effect was …
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CRISPR activation screening at single-cell transcriptomic resolution: discovering new regulators of zygotic genome activation
The maternal-to-zygotic transition in mammals consist of the passing of the developmental control from the mother to the embryo and involves two major events: the depletion of maternal products and the activation of the zygotic genome. Zygotic genome activation, or ZGA, coincides with dramatic …