Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Zonula occludens 1"”.
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Diabetic macular oedema: the role of steroids and VEGF
… and vascular endothelial growth factor-induced zonula occludens-1 loss occurred via different pathways suggesting that zonula occludens-1 loss was unlikely to be the downstream effector of vascular endothelial growth factor-induced permeability. Hydrocortisone leads to a decrease in permeability …
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Human coronavirus NL63 envelope protein-protein interactions: role in pathogenesis
… disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (ZO-1) (PDZ) domain-containing proteins, facilitating immune dysregulation and hyperinflammation. Early work on SARS-CoV-1 revealed that the PBM of its E protein serves as a pathogenic determinant, which was later …
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The Cx43 Carboxyl-Terminal Mimetic Peptide αCT1 Protects Endothelial Barrier Function in a ZO1 Binding-Competent Manner
… VE-cadherin, the Tight Junction protein Zonula Occludens 1 (ZO1) , and the Gap Junction Protein (GJ) Connexin43 (Cx43). A ZO1-binding-incompetent variant of αCT1, αCT1-I, indicated that these effects on barrier function and barrier-associated proteins, were likely associated with Cx43 …
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Biochemical and Immunocytochemical Characterization of Canine Corneal Cells Cultured in Two Different Media
… was evaluated, and immunofluorescence for zonula occludens-1 was attempted. Amplification of cytokeratin 5 (CK5) mRNA was assessed by PCR. Primary presumed epithelial cells grew faster when cultured in DMEM with FBS compared to Epilife®. Stromal tissue segments in Epilife® medium failed to …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… affect protein interactions with 14-3-3 and zonula occludens-1 (ZO-1). While it is established that pS365 creates a conformational change preventing pS368, it is currently unclear precisely how pS373 regulates pS368. Further, it is unclear if alterations to these residues might impact protein …
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Uncovering astrocyte roles at the blood brain barrier in the healthy and concussed brain
… reduced expression of the tight junction protein zonula occludens-1, indicating impairment of the physical barrier formed between endothelial cells. Cadaverine leakage persisted for weeks, a feature I also found in mice after mild concussive traumatic brain injury (cTBI), thus highlighting the …
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The epithelial-mesenchymal transition of hepatocyte in liver cirrhosis
… cell markers such as c-Met, cytokeratin18 and zonula occludens-1 (ZO-1) in contrast to the increase of mesenchymal cell markers such as vimentin and α-SMA. Regarding the hepatocyte function, hepatocytes treated with TGF-β1 revealed a significant decrease in their ammonia-metabolizing activity …
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The Effects of Onion and Yuzu Extracts against Ischemia/Hypoxia-Induced Dysfunction of Blood-Brain Barrier
… of tight junction proteins (TJs; ZO-1 (Zonula occludens-1) and claudin-5). In in vitro model, pre-treatment of OE, Quer, YE, and HSP significantly attenuated hypoxia-induced Blood-Brain Barrier (BBB) hyperpermeability. The four materials also inhibited hypoxia-induced redistribution of …
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INVESTIGATION OF ACUTE STRESS IMPACT ON NURSERY PIG GASTROINTESTINAL FUNCTION AND ABILITY OF BIOACTIVE COMPONENTS OF GARLIC TO MITIGATE STRESS-INDUCED PHYSIOLOGICAL CHANGES
… was a linear increase in IL-8 and a decrease in zonula occludens 1 (ZO-1) ileal gene expression due to oral DADS + DATS administration. The optimal dosage of DATS + DATS to maximize ileal villus height was determined to be 1.7 mg per kg BW. For the broiler chicken trial, DADS + DATS …
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Role of PACAP-ADNP axis in neurodegenerative process
… proteine che costituiscono le giunzioni strette, Zonula Occludens-1 (ZO-1) e occludina. Inoltre, abbiamo dimostrato che l'asse PACAP-ADNP ha contrastato la neovascolarizzazione coroidea promossa da VEGF. In conclusione, gli studi presentati nella tesi evidenziano il ruolo dell'asse PACAP-ADNP …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… At termination of experiment, tight junction (zonula occludens-1, ZO-1) immunostaining and TUNEL staining were performed. To determine the effects of dysglycaemia and pre-eclampsia on placental pathology, term placentae from two study cohorts were utilized. Pathology in placental sections was …
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The Effects of Aging on EGFR/pSTAT3-Dependent Gliovascular Structural Plasticity
… in part, of tight junction proteins such zonula-occludens-1 (ZO1) (6) and Claudin-5 (7). Underlying the execution of these processes is the morphological and spatial arrangement of astrocytes between neurons and endothelial cells comprising blood vessels, where comprehensively speaking, …
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Development of in vitro infant intestinal models to assess responses to infant formulae
… low lactulose:mannitol permeability, strong zonula occludens-1 localization, and low fibroblast marker S100A4 expression. Following exposure to in vitro–digested IF, PS10-cultured IPEC-J2 monolayers exhibited increased TEER and enhanced basolateral amino acid transport, demonstrating …
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New purinergic-based pharmacological targets for the treatment of retinal disorders
… such as vascular endothelial (VE)-cadherin and zonula occludens-1 (ZO-1). In our human inner BRB (iBRB) model, the hyperglycemic environment also led to the over-expression of inflammatory mediators (IL-1β, IL-6) and oxidative stress-related genes (iNOS, Nox2) along with a significant increase …