Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Zoledronate"”.
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
… localization and protein-protein interactions. Zoledronate (ZOL) is a potent antiresorptive agent that definitively reduces the frequency and severity of malignant skeletal complications in people. As an antiresorptive agent, ZOL exerts its biologic effects on osteoclasts by inhibiting the …
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The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats
… the effects of treatment timing using Zoledronate [ZOL], a potent bisphosphonate, on the lumbar and caudal vertebrae in ovariectomized [OVX], female Wistar rats. Methods: Twenty nine rats were divided into four groups according to their treatment: OVX at week 0 (n=5), OVX+earlyZOL (20 …
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Pharmacological manipulation of fracture healing and bone remodeling
… and the animals received weekly injections with zoledronate, an anti-resorptive drug, or saline as control. In the second study the grafts were either pretreated with a bone inducing protein, BMP-7 or saline before surgery. As BMP-7 also induces resorption, the rats received either an injection …
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Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… I and II, the effect of the bisphosphonate zoledronate and BMP-7 on allografts was investigated in a bone conduction chamber in rats. We found a strong synergism of the combined treatment compared to the saline control. Local treatment with the bisphosphonate was efficient but it also tended …
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Force Field Parameters and Atomistic Surface Models forHydroxyapatite and Analysis of Biomolecular Adsorption at Aqueous Interfaces
… for osteoporosis, pamidronate, ibandronate, and zoledronate, were also tested on protonated {001}, {010}, {020}, and {101} surfaces corresponding to pH 5. The P-C-P motif of bisphosphonates interacts with the protonated phosphate by hydrogen bonding or coordinates with the remaining calcium on …
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… concurrent treatment with the bisphosphonate zoledronate (ZOL) could counteract this resorption, leading to superior healing compared to isolated BMP-7 treatment. In studies 1, 2 and 3, the synergistic effect of BMP-7 and zoledronate was investigated in a rat femoral osteotomy model, that …
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The effects of stroke on the skeleton
… 4 mg dose of the intravenous bisphosphonate, zoledronate (n=14) within 35 days of stroke onset. Computed tomography of the hips in 8 untreated patients more than a year after stroke confirmed that the greatest difference between sides was in the trochanteric region. Serum vitamin D …
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Drug discovery against malaria parasite: drug repositioning strategy
… was used to find the lead, an analog of zoledronate, against the parasite, which the x-ray structure bound to target enzyme, farnesyl diphosphate synthase (FPPS), was solved. Also, the effect of lipophilic bisphosphonate against liver stage malaria parasite was investigated. Lastly, I …
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Structure, function and inhibition of GcpE, FPPS and GGPPS: targeting isoprenoid biosynthesis for drug discovery
… of HsFPPS bound to BPH-1260, a C4 version of zoledronate with a hydroxyl group on the bisphosphonate group explains the intrinsic properties of chain length dependence of BPH-703 derivatives. Making potent and selective inhibitors against these three enzymes are important as anti-cancer and …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… inhibitors (Ki ~ 200 nM) were N-alkyl analogs of zoledronate containing ~C6 alkyl side-chains. They were modestly active against S. aureus cell growth, and growth inhibition was partially “rescued” by addition of menaquinone-7. Helicobacter pylori utilizes a completely different menaquinone …
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Wpływ bisfosfonianów stosowanych w terapii osteoporozy na metabolizm tlenowy komórek śródbłonka
… by which N-BPs, such as alendronate and zoledronate, affect energy metabolism, oxidative stress and mitochondrial function in cells. The research material used in the experiments were human endothelial cells EA.hy926, treated for six days with 5 μM alendronate or 1 μM zoledronate, and …