Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Zoledronate"”.
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Investigating the role of zoledronate for inhibition of osteosarcoma metastasis
… localization and protein-protein interactions. Zoledronate (ZOL) is a potent antiresorptive agent that definitively reduces the frequency and severity of malignant skeletal complications in people. As an antiresorptive agent, ZOL exerts its biologic effects on osteoclasts by inhibiting the …
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The effect of Zoledronate treatment timing on lumbar and caudal vertebrae in ovariectomized rats
… the effects of treatment timing using Zoledronate [ZOL], a potent bisphosphonate, on the lumbar and caudal vertebrae in ovariectomized [OVX], female Wistar rats. Methods: Twenty nine rats were divided into four groups according to their treatment: OVX at week 0 (n=5), OVX+earlyZOL (20 …
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Pharmacological manipulation of fracture healing and bone remodeling
… and the animals received weekly injections with zoledronate, an anti-resorptive drug, or saline as control. In the second study the grafts were either pretreated with a bone inducing protein, BMP-7 or saline before surgery. As BMP-7 also induces resorption, the rats received either an injection …
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Allograft bone in hip revision: the effect of locally applied pharmacological treatment.
… I and II, the effect of the bisphosphonate zoledronate and BMP-7 on allografts was investigated in a bone conduction chamber in rats. We found a strong synergism of the combined treatment compared to the saline control. Local treatment with the bisphosphonate was efficient but it also tended …
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Force Field Parameters and Atomistic Surface Models forHydroxyapatite and Analysis of Biomolecular Adsorption at Aqueous Interfaces
… for osteoporosis, pamidronate, ibandronate, and zoledronate, were also tested on protonated {001}, {010}, {020}, and {101} surfaces corresponding to pH 5. The P-C-P motif of bisphosphonates interacts with the protonated phosphate by hydrogen bonding or coordinates with the remaining calcium on …
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Enhancing bone healing through concurrent anabolic- and anti-catabolic pharmacological treatment
… concurrent treatment with the bisphosphonate zoledronate (ZOL) could counteract this resorption, leading to superior healing compared to isolated BMP-7 treatment. In studies 1, 2 and 3, the synergistic effect of BMP-7 and zoledronate was investigated in a rat femoral osteotomy model, that …
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The effects of stroke on the skeleton
… 4 mg dose of the intravenous bisphosphonate, zoledronate (n=14) within 35 days of stroke onset. Computed tomography of the hips in 8 untreated patients more than a year after stroke confirmed that the greatest difference between sides was in the trochanteric region. Serum vitamin D …
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Drug discovery against malaria parasite: drug repositioning strategy
… was used to find the lead, an analog of zoledronate, against the parasite, which the x-ray structure bound to target enzyme, farnesyl diphosphate synthase (FPPS), was solved. Also, the effect of lipophilic bisphosphonate against liver stage malaria parasite was investigated. Lastly, I …
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Structure, function and inhibition of GcpE, FPPS and GGPPS: targeting isoprenoid biosynthesis for drug discovery
… of HsFPPS bound to BPH-1260, a C4 version of zoledronate with a hydroxyl group on the bisphosphonate group explains the intrinsic properties of chain length dependence of BPH-703 derivatives. Making potent and selective inhibitors against these three enzymes are important as anti-cancer and …
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Targeting isoprenoid and quinone biosynthesis for antimicrobial discovery
… inhibitors (Ki ~ 200 nM) were N-alkyl analogs of zoledronate containing ~C6 alkyl side-chains. They were modestly active against S. aureus cell growth, and growth inhibition was partially “rescued” by addition of menaquinone-7. Helicobacter pylori utilizes a completely different menaquinone …