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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"Zn2+"”.
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Developing Red Fluorescent Zn2+ Sensors and Characterizing Zn2+ Homeostasis in Mucolipidosis Type IV Disease
<p>Zinc (Zn<sup>2+</sup>) is a divalent, redox-inert metal that plays a vital role in many cellular processes either by acting as a catalytic cofactor or a labile signaling molecule in the cytoplasm. Cytosolic Zn<sup>2+</sup> levels are tightly regulated to stay within a narrow window of …
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Uncovering Zn2+ and Ca2+ Homeostasis and Crosstalk in Primary Hippocampal Neurons
<p>Zn<sup>2+</sup> has been suggested to act as an intracellular signaling molecule due to its regulatory effects on numerous protein targets including enzymes, transcription factors, ion channels, neurotrophic factors, and postsynaptic scaffolding proteins. However, intracellular Zn<sup>2+</sup> …
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Organellar Zn2+ Homeostasis and the Role of TRPML Channels in Neuronal Lysosome Physiology and Axonal Transport
… but little is known about endolysosomal Zn2+ homeostasis. Similarly, although numerous sensors have been reported, it is unclear whether and how Zn<sup>2+</sup> can be released from intracellular compartments into the cytosol due to a lack of probes that can detect physiological dynamics …
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The role of organic matter and other soil properties in Zn2+ activity and AB-DTPA-extractable Zn in soils
… of Zn deficiency or toxicity. In this study, Zn2+ activity (measured by chelation) was related to soil properties for 18 alkaline soils from three farms in eastern Colorado. Organic carbon and pH were statistically significant parameters in a regression with log Zn2+ activity. Principal …
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Funktionale Analyse des ATPase- und des Zn2+-Bindungs-Motivs der Bacillus subtilis Protease FtsH und deren Einfluss auf die Sporulation
Die membrangebundene, ATP- und Zn2+- abhängige Metalloprotease FtsH ist in E. coli bereits gut untersucht. Es handelt sich um ein multifunktionales Protein mit ATPase- und Protease-Aktivität. Dort wurden eine Vielzahl von E. coli ftsH-Mutanten mit pleiotropen Phänotyp charakterisiert und die …
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Studies on the role of zinc in maintaining antioxidant status in the heart.
Zinc (Zn2+) is an essential micronutrient which plays a pivotal role as a signalling, catalytic and structural component in cells and functions in several physiological processes such as immune function, wound healing, cognition, reproduction and as co-factor for various enzymes involved in …
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Zinc-mediated cell death in the hippocampus following experimental traumatic brain injury
… are largely unknown. Since free ionic zinc (Zn2+) was shown to be toxic to neurons in vitro, I sought to examine the effects of Zn2+ on neuronal injury following TBI. To study this problem, I characterized a model of Zn2+-induced injury in an attempt to isolate zinc’s effect on cell death, in …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… low, intracellular zinc ion concentrations, [Zn2+]i, are tightly controlled to ensure optimal physiology and to avoid toxicity. Furthermore, zinc ions are now believed to be signaling ions, especially in neuronal systems. This dissertation addresses the dynamics of [Zn2+]i and quantitatively …
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Investigating CO2 Adsorption Behavior in Metal-Organic Frameworks by Solid-state NMR
… the adsorption behavior of CO2 molecules in [Zn2(TRZ)2(NH2-BDC)] (TRZ=1,2,4-triazolate, NH2-BDC=2-amino-1,4-benzenedicarboxylic acid), and CALF-20 are studied. Moreover, water is ubiquitous in the atmosphere and could have a negative impact on the MOF’s gas adsorption. Therefore, understanding …
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Zinc ion fluxes on the pathway to mammalian sperm fertilization competency
… on other divalent ions, including zinc ion (Zn2+). Further, the ultimate maturation event preparing mammalian spermatozoa for fertilization, sperm capacitation, was first described in 1951, yet its regulatory mechanisms remain poorly understood. Here, we document a novel biological phenomenon …
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Investigation of zinc metalloneurochemistry with fluorescent sensors based on fluorescein platforms
… nitric oxide. Chapter 2. Fluorescent Sensors for Zn2' Based on a Fluorescein Platform: Synthesis, Properties and Intracellular Distribution Two new fluorescent sensors for Zn2' that utilize fluorescein as a reporting group, Zinpyr-1 (ZP1) and Zinpyr-2 (ZP2), have been synthesized and …
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Preparo e avaliação do hidróxido duplo lamelar de cálcio e alumínio na remoção de cobre(II), níquel(II), zinco(II) e cromo(VI) de solução aquosa
… HC) na remoção dos íons metálicos Cu2+, Ni2+ e Zn2+, por meio do processo de reconstrução lamelar com base no método de precipitação química. A hidrocalumita obtida neste estudo foi sintetizada pelo método de coprecipitação em diferentes proporções de cálcio e alumínio (Ca:Al), sendo que a …
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Localization of metal ions in DNA
… that only 50% of the DNA is able to incorporate Zn2+ ions at pH 7.9. This suggests that only regions corresponding to the tracts of d(TG)•d(CA) are being transformed. Duplex DNA monolayers were self-assembled on gold through a Au-S linkage and both B- and M-DNA conformations were studied using …
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DENSITY FUNCTIONAL THEORY STUDIES OF PHOTOINDUCED ELECTRON EXCITATION AND TRANSFER OF ORGANIC DYES FOR PHOTODYNAMIC THERAPY, SOLAR CELLS, AND FLUORESCENCE SENSOR APPLICATIONS
… anthracene-based sensor after the addition of Zn2+. A 23-fold fluorescence emission was quenched via non-radiative decay pathway in the absence of Zn2+. However, when the Zn2+ chelated to the sensor fluorescence intensity was increased remarkably. A 32-fold fluorescence increase was overserved …
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La percezione del gusto amaro nell’uomo: la sensibilità gustativa al 6-n-propiltiouracile (PROP) come marker della variabilità individuale con implicazioni fisiologico-nutrizionali
… gene polymorphism rs2274333 (A/G), salivary Zn2+concentration and BMI. BMI were determined in 76 volunteers (29 males, 47 females, age 25 ± 3 y). PROP phenotype was determined by scaling methods and threshold measurements. The salivary Zn2+ concentration was determined and molecular analysis …
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An improved understanding of fluorescent Zn(II) sensors and their uses in biological settings
… Containing Dichlorofluorescein-Based Zn2+ Sensors The syntheses of five new analogues of the 2',7'-dichlorofluorescein-based Zn2+ sensor Zinpyr-1 (ZP1) are reported. Analysis of these fluorophores by absorption and emission spectroscopy, in combination with potentiometric titrations, …
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Synthesis and characterization of terpyridine-based fluorescent coordination polymers
… have been determined. These studies reveal that Zn2+ is the best suited metal ion for the reversible coordination of the terpyridine ligand. Thus, supramolecular coordination polymerization of perylene bisimide fluorophores containing terpyridine functionalities have been investigated by using …
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A CrpA transzporter szerepének vizsgálata stresszkezelt felületi Aspergillus nidulans tenyészetekben
… hogy a CrpA ATPáznak lehet-e szerepe a Zn2+ ionok szekréciójában. Eredményeink alapján mindhárom mutáns törzs lényegesen érzékenyebbnek bizonyult a ZnSO4 túladagolására, mint a referencia törzs. A Fe2+ helyett csak a Fe3+ ionok hatását tudtuk vizsgálni, azonban a mutáns és a referencia …
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ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ
… OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO IN ALL THESE COMPLEXES IS 1:1. WE HAVE ALSO PREPARED NINE COMPLEXES (1:1, 1:2) OF 6-MERCAPTOPURINE AND ITS RIBOSIDE WITH RU3+, RB3+, IR3+, R. WEHAVE PREPARED THE …
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DEVELOPMENT OF A NEW CHIRAL MONOLITHIC CAPILLARY COLUMN AND A FLUORESCENCE SPECTROSCOPIC STUDY OF A SELECTIVE OFF-ON PET SENSOR FOR THE DETECTION OF ZINC IONS
… that has been developed in our laboratory for Zn2+ recognition via a photo-induced electron transfer (PET) sensing mechanism. To characterize the fundamental function of sensor, response curves have been conducted, using acetone/methanol (199:1), 1,4-dioxane, acetone, methanol and aqueous …
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