Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Zn Superoxide Dismutase"”.
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Electrostatic control of Cu, Zn superoxide dismutase aggregation in Amyotrophic Lateral Sclerosis : from lysine modification to interaction with lipid membranes.
Cu, Zn superoxide dismutase (SOD1) is a ubiquitous metalloprotein, which is responsible for protecting living cells from oxidative stress via disproportionation of superoxide ions. Misfolding and subsequent aggregation of SOD1 is casually linked to familial and sporadic cases of amyotrophic lateral …
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Overexpression of human Cu/Zn Superoxide Dismutase in Mice; The Effect of Increase Superoxide Scavenging on Autonomic Control of the Heart.
… in neural, cardiac, and endothelial tissues. Cu/Zn superoxide dismutase (SOD1) is an intracellular anti-oxidant enzyme that catalyzes dismutation of the superoxide anion (O2.-) to hydrogen peroxide (H2O2). Expression and function of this enzyme are diminished in pathologies that impair …
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Behavioral, Neurochemical, and Histological Characterization of Mice Deficient for Parkin, DJ-1, and Antioxidant Proteins
… the major mitochondrial antioxidant protein Mn-superoxide dismutase or Cu/Zn-superoxide dismutase. Previous studies have shown that mice with reduced levels of Cu/Zn-superoxide dismutase or Mn-superoxide dismutase are more sensitive to dopaminergic neurotoxins whereas mice with increased levels …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
Cu, Zn Superoxide dismutase (SOD1) is an essential metalloenzyme that regulates superoxide radicals. Because SOD1 is a long-lived protein, it contains an intrinsic molecular clock, deamidation, that accumulates over time. Misfolding and aggregation of SOD1 have been linked to neurodegenerative …
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DNA Repair, Redox Regulation and Modulation of Estrogen Receptor Alpha Mediated Transcription
… as well as the oxidative stress proteins Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and protein disulfide isomerase (PDI) are overexpressed in human breast cancer tissues. These studies provide a novel link between DNA repair, redox regulation and modulation of ERalpha-mediated …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… in oxidative stress response including Cu/Zn superoxide dismutase (SOD1), thioredoxin (Trx) and thioredoxin reductase (TrxR). We found that SOD1 interacts with ERalpha, enhances ERalpha-ERE complex formation, influences estrogen responsiveness and associates with estrogen responsive regions …
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A maternal high fat diet represses the expression of antioxidant defense genes and induces the cellular senescence pathway in the liver of male offspring rats
… such as glutathione peroxidase-1 (Gpx1), Cu/Zn superoxide dismutase (Sod1), paraoxonase enzymes (Pon1, Pon2, and Pon3) were significantly lower in the liver of HF/C pups than in C/C pups. The expression of p16INK4a, a marker of cellular senescence, and cyclooxygenase-2 (Cox2), a …
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Brucella abortus Strain RB51 Outer Membrane Vesicles as a Vaccine Against Brucellosis in a Murine Model
… Strain RB51 and strain RB51 over-producing Cu/Zn superoxide dismutase (Cu/Zn SOD) were used to produce OMV. Western blotting and SDS-PAGE gel staining confirmed the presence of OMV and the over-production of Cu/Zn SOD. OMV were delivered to mice using an intraperitoneal route and, in some …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… cases of ALS have been linked to mutations in Cu/Zn superoxide dismutase (SOD1), resulting in mitochondrial oxidative stress and intrinsic apoptosis. Transgenic mice expressing a G93A mutant of SOD1 provide an in vivo model to investigate motor neuron death during disease progression. The …
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Biotic and abiotic interactions of deep-sea hydrothermal vent-endemic fish on the East Pacific Rise
… to ambient bottom water. A fragment of Cu, Zn superoxide dismutase was successfully amplified from T. hollisi mRNA, but there were no differences in expression levels between tissue types or among individuals within the small sample examined. In general, it appears that T. hollisi is both …
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Structure-function studies of the Parkinsonism-linked protein DJ-1
… the copper cofactor for the activation of the Cu-Zn superoxide dismutase (SOD1). Using absorption spectroscopy and mass spectrometry, we found that DJ-1 binds one Cu(I) ion per DJ-1 homodimer. The structure of Cu(I)-bound DJ-1 reveals a new biscysteinate metal binding motif formed by juxtaposed …
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Evaluation of the Aging Immune System Using a Mouse Model of Brucella Infection
… B. abortus strain RB51 over-expressing Cu-Zn superoxide dismutase (SOD) and then challenged with B. abortus strain 2308 to determine the effect of vaccination in old vs. young mice. Specific IgG1 and IgG2a response to Brucella antigens were also evaluated to determine the effect of aging on …
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Mechanisms of Ipsapirone-Mediated Neuroprotection of Ethanol-Treated Fetal Rhombencephalic Neurons: Role of Endogenous Antioxidants
… activities of endogenous antioxidants Cu/Zn-superoxide dismutase (SOD1), Mn-superoxide dismutase (SOD2), and catalase.</p><p>The results of these studies demonstrate that ethanol induces an increase in ROS and that ipsapirone pre-treatment prevents this increase. Time-course studies of the …
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Influence of Growth Factors on Bovine Embryo Development
… the oxidative stress genes, copper (Cu)-zinc (Zn) superoxide dismutase (SOD; SOD1) and manganese (Mn) SOD (SOD2) in embryos was assessed. No significant treatment effect was observed on the expression of apoptotic and oxidative stress genes. Bax was expressed strongly (4-fold) in morulae with …
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Synthesis and Characterization of Novel Polyethers and Polypeptides for Use in Biomedicine and Magnetic Resonance Imaging
… was conjugated to an antioxidant enzyme, Cu/Zn superoxide dismutase (SOD1). The conjugates were characterized and their cellular uptake was investigated.
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Neuronal and Mitochondrial Protection in Chronic Parkinsonism
… as well as loss of antioxidant enzymes, Cu-Zn superoxide dismutase (SOD), Mn SOD and cytochrome c (cyt c) expression. Striatal mitochondrial dysfunction correlated with dopamine neuron and behavioral deficits in the aged chronic MPD. When the chronic MPD was exercise-trained on a motorized …
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Identification and Characterization of Factors Involved in Sodium Selenite Toxicity
… that the SeL toxicity can be modulated by Cu/Zn superoxide dismutase 1 (Sod1) activity. This observation was surprising since Sod1 is one of the most important antioxidant enzymes and is needed for ROS tolerance. Interestingly, substitution of Sod1 by the E. coli Fe SodB enzyme suppressed SeL …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… of those are dominantly inherited mutations in superoxide dismutase 1 (SOD1). The transgenic animal model of ALS was the G93A mouse that expresses a mutant form of human SOD1 carrying the Gly93 → Ala and develops motor neuron disease similar to familial ALS. With the lack of effective drug …
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Amyotrophic Lateral Sclerosis: mechanism behind mutant SOD toxicity and improving current therapeutic strategies
… neuron survival was investigated in mutant Cu/Zn superoxide dismutase (SOD) transgenic animal models for ALS. Nitrated Hsp90, a posttranslational modification known to induce cell death (Franco, Ye et al. 2013), was present in motor neurons after intracellular release of zinc deficient (Zn, …
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The Neuroprotective and Therapeutic Effects of Anthocyanins and Their Metabolites In Vitro and in a Mouse Model of Amyotrophic Lateral Sclerosis
… survival in the transgenic G93A mutant Cu, Zn-superoxide dismutase (hSOD1<sup>G93A</sup>) mouse model of ALS. These observations correlate with significant preservation of hind limb grip strength and function in mice treated with anthocyanins. Anthocyanin supplementation is also shown to …
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