Global ETD Search
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Showing 1 to 4 of 4 for “"Zmpste24"”.
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Role of Zmpste24 in Prelamin A Maturation.
… with knockout mice have implicated the enzyme Zmpste24 as a candidate to carry out one or both of these proteolytic reactions. In this body of work, the CAAX endopeptidase activity of recombinant, membrane reconstituted, Zmpste24 is demonstrated using a prelamin A farnesylated tetrapeptide as …
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Analysis of the immune function and its relevance in mouse models of premature aging
… de Hutchinson-Gilford (HGPS), LmnaG609G/G609G y Zmpste24-/-, con el objetivo de identificar nuevos factores que promueven el envejecimiento prematuro y su similitud con el envejecimiento fisiológico. Para este fin, realizamos un análisis global del proteoma del plasma en estos modelos, …
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Functional relevance of mitochondrial proteases in metabolism and cancer
… causado por deficiencia en la metaloproteasa Zmpste24. Nuestro trabajo en este sentido ha permitido definir los mecanismos subyacentes al fenotipo de lipodistrofia que presentan dichos ratones mutantes y puede abrir nuevas estategias para el tratamiento de enfermedades devastadoras como la …
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The Application of a Statistical Model Investigating Reactive Oxygen Species in Premature Ageing Syndromes
… roots in the mutation of the metalloprotease Zmpste24, which has a vital role in the processing of prelamin A. The mutation results in the accumulation of immature prelamin A at the nuclear membrane. As a result of increased understanding of the defects in HGPS arising from LMNA mutations a …