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Showing 1 to 20 of 32 for “"Zinc finger transcription factor"”.
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Protein-DNA Recognition Models for the Homeodomain and C2H2 Zinc Finger Transcription Factor Families
Transcription factors: TFs) play a central role in the gene regulatory network of each cell. They can stimulate or inhibit transcription of their target genes by binding to short, degenerate DNA sequence motifs. The goal of this research is to build improved models of TF binding site recognition. …
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The Expression of the Zinc Finger Transcription Factor zDC Defines the Classical Dendritic Cell Lineage
… cDCspecific genes identified an uncharacterized zinc finger transcription factor that I call zDC (Zbtb46, Btbd4). This factor is expressed by cDCs but not other myeloid or lymphoid immune populations. The characterization of zDC expression and function involved three major directions. (1) To …
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The role of Wt1 in Müllerian duct development
<p>WT1 is a zinc finger transcription factor widely expressed in the urogenital system. Human mutations of <em>WT1</em> lead to pediatric nephroblastoma as well as frequent differences of sex development (DSDs). Previous studies have suggested that WT1 acts as an activator for <em>Amhr2</em>, a …
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Glia Delimit Shape Changes Of Sensory Neuron Receptive Endings in C. elegans
… Remodeling of the glia requires the Otd/Otx transcription factor TTX-1, the C2H2 zinc finger transcription factor ZTF-16, the fusogen AFF-1, and likely the VEGFR-related protein VER-1, all acting within the glial cell. ver-1 expression is induced by dauer entry and by cultivation at high …
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The study of transcriptional regulation of necrotrophic effector genes ToxA and Tox3 in the wheat pathogen Parastagonospora nodorum
… is largely unclear. To better understand the transcriptional regulation of ToxA and Tox3, I conducted functional analyses on their promoter regions to identify the key factors for the regulation in P. nodorum. Being a necrotroph, P. nodorum tends to acquire nutrients from surrounding …
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The study of transcriptional regulation of necrotrophic effector genes ToxA and Tox3 in the wheat pathogen Parastagonospora nodorum
… is largely unclear. To better understand the transcriptional regulation of ToxA and Tox3, I conducted functional analyses on their promoter regions to identify the key factors for the regulation in P. nodorum. Being a necrotroph, P. nodorum tends to acquire nutrients from surrounding …
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Identification of juvenile hormone response genes in newly emerged female Aedes aegypti
… such gene, AaKr-h1, is a homologue of Kr-h1, a zinc-finger transcription factor which has been characterized in Manduca sexta, Drosophila melanogaster, Tribolium castaneum, and Apis mellifera, and is involved in a diverse range of JH-regulated pathways. AaKr-h1 demonstrated a dose-dependent …
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EPIGENETIC AND FUNCTIONAL ASSESSMENT OF ENHANCEROPATHIES ACROSS HUMAN MODELS: FOCUS ON GABRIELE-DE VRIES SYNDROME
Yin Yang 1 (YY1) is a ubiquitous zinc finger transcription factor (TF) that occupies active enhancers and promoters contributing to physical interactions between these regions via DNA looping. Increasing evidence shows that disruption of non-coding regions such as enhancers is prevalent across …
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The role of the transcription factor JAGGED in early floral organogenesis
… targeted by developmental regulators. The single zinc finger transcription factor JAGGED (JAG) is a direct target of several floral organ identity genes and is expressed in early organ primordia (Dinneny et al., 2004; Ohno et al., 2004; Gomez et al., 2005; Kaufmann et al., 2009). Loss of function …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
… SE) in avian cochlea and utricle on a custom transcription factor microarray following damage by laser and chemical ablation and identified genes from known signaling cascades differentially expressed during SE regeneration. In the second study, we selected 27 of these genes for knockdown by …
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ZIPRO1: Fine Tuning Proliferation in Discrete Cell Populations
<p>Zipro 1 is a zinc finger transcription factor that has a restricted pattern of expression in several tissues. The main cells expressing Zipro1 are proliferating cells from epidermal lineages. This includes the cerebellar granule cells (GCs), nasal epithelia and dermal papilla. Through gene …
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The transcription factor Zfx is required for tumorigenesis caused by Hedgehog pathway activation
… Little is known about common cell-intrinsic factors that control the development of such diverse Hh-dependent tumors. The zinc-finger transcription factor Zfx is required for the self-renewal of several stem cell types in both mouse and human, but its role in malignant transformation remains …
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Discovery and Characterization of the Polycomb Repressive Complex 1 of C. Elegans
… elegans homolog of the Olf-1/Early B cell factor family of transcription factors, which in vertebrates regulate development and differentiation of B lymphocytes, adipocytes, and cells of the nervous system. In the first chapter I analyze the role of unc-3 in determining the fates of neurons …
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A New Type of Programmed Cell Death in C. Elegans
… is controlled by the microRNA let-7 and by the zinc finger transcription factor lin-29, both components of the main developmental timing pathway in the animal. Conducting a genome-wide RNAi screen, we have identified new candidate regulators of linker cell death. Characterization of these genes …
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Molecular Mechanisms Underlying Stress-Induced Glia Remodeling in the Nematode C. Elegans
… a VEGFR-related protein VER-1, (3) the Otd/Otx transcription factor TTX-1, and (4) the zinc-finger transcription factor ZTF-16. ver-1 expression in AMsh glia is induced by dauer entry or by cultivation at high temperature, and requires direct binding of TTX-1 to ver-1 regulatory sequences. To …
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Molecular mechanisms underlying Juvenile hormone (JH) signaling pathway
… receptor Methoprene-tolerant (MET). MET is a transcription factor of the basic helix-loop-helix (bHLH)/Per-Arnt-Sim (PAS) family. In the presence of JH, MET forms a heterodimer with its DNA-binding partner Taiman (TAI). The MET-TAI complex directly binds to the regulatory regions of some JH …
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PHOTOPERIODIC REGULATION OF RICE STEM ELONGATION BY THE GENE PINE1
… flowering with stem elongation [1]. PINE1 is a zinc finger transcription factor able to repress stem elongation during vegetative growth. During floral induction, the florigenic signal can silence PINE1 expression, triggering internode elongation. This thesis aims to explore the mechanism of …
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Gene duplication and alternative splicing play a role in modulating the functions of the ZNF286A transcription factor
… network involving many known and conserved transcription factors regulates these functions. We have identified a novel zinc finger transcription factor (TF), ZNF286A, which is conserved in all eutherians and marsupials and provide evidence that this novel TF plays a role in regulation of …
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Characterization of Transcriptional and Post-transcriptional Regulation of lin-42/Period During Post-embryonic Development of C. elegans
… cis-regulatory elements and the trans-regulatory factors that control lin-42 expression. We used direct molecular interaction assays (Electrophoretic Mobility Shift Assay, EMSA) (Chapter 2) followed by an RNA interference (RNAi)-based genetic screen (Chapter 3) to identify lin-42 transcriptional …
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The Albino Mouse Visual System: How Perturbed Retinal Development Leads to Altered Binocular Projections
… Previously, our lab has shown that Zic2, a zinc finger transcription factor that is expressed in ventrotemporal RGCs from E14.5-E17.5, directs the ipsilateral projection. Zic2 regulates several programs of gene expression important for axon guidance and synaptic connectivity. Zic2 is …
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